BAKER BROS. ADVISORS LP Q1 2016 Filing

Filed May 16, 2016

Portfolio Value

$9.5B

Holdings

134

Report Date

Q1 2016

Filing Type

13F-HR

All Holdings (134 positions)

#StockSharesValue% PortfolioType
101
Immune Design Corp.
148,937$1.9B20.42%
102
KPTIEURKaryopharm Therapeutics Inc.
216,990$1.9B20.42%
103
IRWDIronwood Pharmaceuticals, Inc.
169,163$1.9B19.52%
104
MediWound Ltd.
226,000$1.8B19.24%
105
CytRx Corporation
659,995$1.8B18.66%
106
Stemline Therapeutics, Inc.
333,497$1.6B16.39%
107
Ophthotech Corporation
35,649$1.5B15.89%
108
Affimed N.V.
400,000$1.5B15.78%
109
DVAXDynavax Technologies Corporation
75,000$1.4B15.22%
110
CLLSCellectis S.A.
50,000$1.4B14.50%
111
ProNai Therapeutics, Inc.
200,000$1.3B14.22%
112
Mast Therapeutics, Inc.
4,797,442$1.3B13.80%
113
ASMBAssembly Biosciences, Inc.
250,000$1.3B13.24%
114
AMRNAmarin Corporation plc
801,860$1.2B12.94%
115
Palatin Technologies, Inc.
2,050,000$1.1B11.67%
116
GW Pharmaceuticals plc
15,000$1.1B11.41%
117
Tenax Therapeutics, Inc.
420,000$861.0M9.08%
118
ADAPYAdaptimmune Therapeutics plc
100,000$813.0M8.57%
119
Five Prime Therapeutics, Inc.
19,247$782.0M8.25%
120
XLRNAcceleron Pharma, Inc.
28,765$759.0M8.00%
121
I9DNArbutus Biopharma Corporation
180,582$746.0M7.87%
122
ALNYAlnylam Pharmaceuticals, Inc.
11,340$712.0M7.51%
123
BioDelivery Sciences International, Inc.
210,021$678.0M7.15%
124
ALDXAldeyra Therapeutics, Inc.
142,000$595.0M6.27%
125
CMRXEURChimerix, Inc.
115,216$589.0M6.21%
126
Ritter Pharmaceuticals, Inc.
400,000$452.0M4.77%
127
Discovery Laboratories, Inc.
254,973$426.0M4.49%
128
Foundation Medicine, Inc.
20,892$380.0M4.01%
129
La Jolla Pharmaceutical Company
13,746$287.0M3.03%
130
Achaogen, Inc.
100,000$276.0M2.91%
131
CCXIEURChemoCentryx, Inc.
49,064$122.0M1.29%
132
Aptose Biosciences Inc.
33,397$100.0M1.05%
133
BGMS 6 PERPCyclacel Pharmaceuticals, Inc.
13,253$76.0M0.80%
134
BioTime, Inc.
20,084$12.0M0.13%
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