BAKER BROS. ADVISORS LP Q4 2019 Filing

Filed February 14, 2020

Portfolio Value

$18.8T

Holdings

99

Report Date

Q4 2019

Filing Type

13F-HR

All Holdings (99 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
50,057,277$5.7T30.41%
2
INCYIncyte Corporation
31,976,873$2.8T14.84%
3
ONCBeiGene, Ltd.
11,777,285$2.0T10.38%
4
ACADACADIA Pharmaceuticals Inc.
40,854,586$1.7T9.29%
5
ALXNAlexion Pharmaceuticals, Inc.
8,258,068$893.1B4.75%
6
KODKodiak Sciences Inc.
11,047,289$794.9B4.23%
7
AMRNAmarin Corporation plc
34,496,685$739.6B3.93%
8
BMRNBioMarin Pharmaceutical Inc.
7,589,294$641.7B3.41%
9
ASNDAscendis Pharma A/S
3,390,270$471.7B2.51%
10
EXASExact Sciences Corporation
2,585,791$239.1B1.27%
11
MRTXEURMirati Therapeutics, Inc.
1,307,220$168.4B0.90%
12
ARGXargenx SE
1,019,557$163.7B0.87%
13
DBV Technologies S.A.
14,614,264$156.4B0.83%
14
NVTA1EURInvitae Corporation
9,097,165$146.7B0.78%
15
HRTXHeron Therapeutics, Inc.
6,018,104$141.4B0.75%
16
NBIXNeurocrine Biosciences, Inc.
1,254,243$134.8B0.72%
17
MyoKardia, Inc.
1,774,234$129.3B0.69%
18
1K0IGM Biosciences, Inc.
3,144,000$120.0B0.64%
19
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$106.5B0.57%
20
Ra Pharmaceuticals, Inc.
2,093,839$98.3B0.52%
21
Principia Biopharma Inc.
1,787,957$97.9B0.52%
22
AXSMAxsome Therapeutics, Inc.
829,757$85.8B0.46%
23
Zymeworks Inc.
1,708,472$77.7B0.41%
24
1T7Tricida, Inc.
1,969,905$74.3B0.40%
25
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$62.2B0.33%
26
IM8NInsmed Incorporated
2,445,265$58.4B0.31%
27
KRYSKrystal Biotech, Inc.
1,034,674$57.3B0.30%
28
BCELAtreca, Inc.
3,532,760$54.7B0.29%
29
Audentes Therapeutics, Inc.
804,720$48.2B0.26%
30
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$47.1B0.25%
31
CERSCerus Corporation
10,749,937$45.4B0.24%
32
Neoleukin Therapeutics, Inc.
3,397,740$41.9B0.22%
33
GW Pharmaceuticals plc
370,845$38.8B0.21%
34
BCRXBioCryst Pharmaceuticals, Inc.
10,946,166$37.8B0.20%
35
QUREuniQure N.V.
517,700$37.1B0.20%
36
AUPHAurinia Pharmaceuticals Inc.
1,701,929$34.5B0.18%
37
ADPTAdaptive Biotechnologies Corporation
1,115,411$33.4B0.18%
38
ALLKGUSDAllakos Inc.
339,690$32.4B0.17%
39
ASMBAssembly Biosciences, Inc.
1,541,618$31.5B0.17%
40
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$31.0B0.16%
41
CCXIEURChemoCentryx, Inc.
739,016$29.2B0.16%
42
MRUSMerus N.V.
2,037,469$28.7B0.15%
43
URGNUroGen Pharma Ltd.
831,488$27.7B0.15%
44
Aimmune Therapeutics, Inc.
673,908$22.6B0.12%
45
Frequency Therapeutics, Inc.
1,231,433$21.6B0.11%
46
ALKSAlkermes plc
793,130$16.2B0.09%
47
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$15.8B0.08%
48
Urovant Sciences Ltd.
1,000,000$15.5B0.08%
49
APLSApellis Pharmaceuticals, Inc.
496,969$15.2B0.08%
50
XNCRXencor, Inc.
428,120$14.7B0.08%
51
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$13.1B0.07%
52
HOOKGBPHOOKIPA Pharma Inc.
892,857$10.9B0.06%
53
CABACabaletta Bio, Inc.
636,363$8.9B0.05%
54
NXTCNextCure, Inc.
150,000$8.4B0.04%
55
Idera Pharmaceuticals, Inc.
4,608,786$8.4B0.04%
56
RETAEURReata Pharmaceuticals, Inc.
40,983$8.4B0.04%
57
GBYSangamo Therapeutics, Inc.
999,823$8.4B0.04%
58
PTGXProtagonist Therapeutics, Inc.
1,174,282$8.3B0.04%
59
MIRMMirum Pharmaceuticals, Inc.
333,333$8.2B0.04%
60
Abeona Therapeutics Inc.
2,288,235$7.5B0.04%
61
FLGTFulgent Genetics, Inc.
569,444$7.3B0.04%
62
IFRXInflarx N.V.
1,778,415$7.0B0.04%
63
BDQMAlbireo Pharma, Inc.
250,000$6.4B0.03%
64
Constellation Pharmaceuticals, Inc.
133,333$6.3B0.03%
65
MTNBEURMatinas BioPharma Holdings, Inc.
2,632,348$6.0B0.03%
66
VSAREURAravive, Inc.
433,333$5.9B0.03%
67
Millendo Therapeutics, Inc.
833,333$5.6B0.03%
68
ORTXUSDOrchard Therapeutics plc
405,702$5.6B0.03%
69
CPRXCatalyst Pharmaceuticals, Inc.
1,341,902$5.0B0.03%
70
Syros Pharmaceuticals, Inc.
690,167$4.8B0.03%
71
Evofem Biosciences, Inc.
756,813$4.7B0.02%
72
NGMUSDNGM Biopharmaceuticals, Inc.
250,000$4.6B0.02%
73
Molecular Templates, Inc.
316,730$4.4B0.02%
74
CRNXCrinetics Pharmaceuticals, Inc.
175,000$4.4B0.02%
75
YMABUSDY-mAbs Therapeutics, Inc.
138,514$4.3B0.02%
76
TPIVDEURMarker Therapeutics, Inc.
1,500,000$4.3B0.02%
77
bluebird bio, Inc.
40,000$3.5B0.02%
78
Bellicum Pharmaceuticals, Inc.
2,677,818$3.5B0.02%
79
VKTXViking Therapeutics, Inc.
425,000$3.4B0.02%
80
GTHXEURG1 Therapeutics, Inc.
127,236$3.4B0.02%
81
Menlo Therapeutics Inc.
700,000$3.2B0.02%
82
Harpoon Therapeutics, Inc.
214,285$3.2B0.02%
83
GLPGGalapagos NV
13,072$2.7B0.01%
84
AUTLAutolus Therapeutics plc
156,773$2.1B0.01%
85
NTLAIntellia Therapeutics, Inc.
128,538$1.9B0.01%
86
ANABAnaptysBio, Inc.
113,086$1.8B0.01%
87
CTMXCytomX Therapeutics, Inc.
194,377$1.6B0.01%
88
IDYAIDEAYA Biosciences, Inc.
200,000$1.5B0.01%
89
GLMDGalmed Pharmaceuticals Ltd.
215,594$1.2B0.01%
90
RCUSArcus Biosciences, Inc.
121,534$1.2B0.01%
91
OPHTEURIVERIC bio, Inc.
141,750$1.2B0.01%
92
TREURTrillium Therapeutics Inc.
1,100,000$1.1B0.01%
93
LPTXEURLeap Therapeutics, Inc.
978,454$1.1B0.01%
94
Spring Bank Pharmaceuticals, Inc.
613,144$969.0M0.01%
95
Adamas Pharmaceuticals, Inc.
172,630$654.0M0.00%
96
INFIQInfinity Pharmaceuticals, Inc.
580,400$557.0M0.00%
97
Affimed N.V.
200,000$548.0M0.00%
98
DVAXDynavax Technologies Corporation
75,000$429.0M0.00%
99
Sunesis Pharmaceuticals, Inc.
556,665$188.0M0.00%