| 1 | GILEAD SCIENCES, INC. | 16,707,477 | $550.6M | 28.45% | Share |
| 2 | TANG CAPITAL MANAGEMENT LLC | 3,921,219 | $128.2M | 6.33% | Share |
| 3 | Madison Avenue Partners, LP | 2,213,169 | $72.4M | 3.11% | Share |
| 4 | EcoR1 Capital, LLC | 1,667,119 | $54.5M | 2.47% | Share |
| 5 | Prosight Management, LP | 1,074,112 | $35.1M | 7.26% | Share |
| 6 | AMERIPRISE FINANCIAL INC | 1,065,320 | $34.0M | 0.01% | Share |
| 7 | Point72 Asset Management, L.P. | 486,209 | $15.0M | 0.02% | Share |
| 8 | SEGALL BRYANT & HAMILL, LLC | 448,096 | $14.7M | 0.20% | Share |
| 9 | DME Capital Management, LP | 376,063 | $12.3M | 0.43% | Share |
| 10 | AMERIPRISE FINANCIAL INC | 385,906 | $12.0M | 0.00% | Share |
| 11 | UBS Group AG | 349,110 | $11.4M | 0.00% | Share |
| 12 | MILLENNIUM MANAGEMENT LLC | 339,354 | $11.0M | 0.00% | Share |
| 13 | RENAISSANCE TECHNOLOGIES LLC | 310,600 | $10.0M | 0.02% | Share |
| 14 | BlackRock, Inc. | 275,293 | $9.0M | 0.00% | Share |
| 15 | D. E. Shaw & Co., Inc. | 274,999 | $8.0M | 0.00% | Share |
| 16 | Hudson Bay Capital Management LP | 170,000 | $5.0M | 0.02% | Share |
| 17 | DAFNA Capital Management LLC | 130,175 | $4.3M | 0.99% | Share |
| 18 | DME Capital Management, LP | 106,683 | $3.5M | 0.12% | Share |
| 19 | KOTLER KEVIN | 90,000 | $2.9M | 0.69% | Share |
| 20 | MORGAN STANLEY | 64,451 | $2.0M | 0.00% | Share |
| 21 | CITADEL ADVISORS LLC | 83,911 | $2.0M | 0.00% | Share |
| 22 | NORGES BANK | 90,000 | $2.0M | 0.00% | Share |
| 23 | Massar Capital Management, LP | 39,000 | $1.3M | 0.14% | Share |
| 24 | Crossmark Global Holdings, Inc. | 32,977 | $1.1M | 0.02% | Share |
| 25 | Monaco Asset Management SAM | 32,520 | $1.1M | 0.18% | Share |
| 26 | Western Standard LLC | 32,000 | $1.0M | 0.48% | Share |
| 27 | Man Group plc | 47,581 | $1.0M | 0.00% | Share |
| 28 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,856 | $1.0M | 0.00% | Share |
| 29 | ALPS ADVISORS INC | 53,791 | $1.0M | 0.01% | Share |
| 30 | FMR LLC | 56,968 | $1.0M | 0.00% | Share |
| 31 | BAROMETER CAPITAL MANAGEMENT INC. | 37,100 | $883K | 0.21% | Share |
| 32 | MOODY NATIONAL BANK TRUST DIVISION | 20,849 | $681K | 0.07% | Share |
| 33 | QRG CAPITAL MANAGEMENT, INC. | 16,170 | $528K | 0.01% | Share |
| 34 | Ascent Group, LLC | 6,237 | $203K | 0.01% | Share |
| 35 | GROUP ONE TRADING LLC | 5,400 | $176K | 0.00% | Call |
| 36 | China Universal Asset Management Co., Ltd. | 2,356 | $77K | 0.01% | Share |
| 37 | SIGNATUREFD, LLC | 1,641 | $53K | 0.00% | Share |
| 38 | GAMMA Investing LLC | 1,250 | $40K | 0.00% | Share |
| 39 | State of Wyoming | 1,227 | $40K | 0.00% | Share |
| 40 | CACTI ASSET MANAGEMENT LLC | 1,000 | $33K | 0.00% | Share |
| 41 | Mirae Asset Global Investments Co., Ltd. | 702 | $22K | 0.00% | Share |
| 42 | DV EQUITIES, LLC | 332 | $10K | 0.00% | Share |
| 43 | UBS Group AG | 334 | $10K | 0.00% | Share |
| 44 | Zurcher Kantonalbank (Zurich Cantonalbank) | 281 | $9K | 0.00% | Share |
| 45 | GF FUND MANAGEMENT CO. LTD. | 282 | $9K | 0.00% | Share |
| 46 | Caitong International Asset Management Co., Ltd | 292 | $9K | 0.02% | Share |
| 47 | Farther Finance Advisors, LLC | 145 | $4K | 0.00% | Share |
| 48 | Allworth Financial LP | 139 | $4K | 0.00% | Share |
| 49 | US BANCORP \DE\ | 100 | $3K | 0.00% | Share |
| 50 | US BANCORP \DE\ | 71 | $2K | 0.00% | Share |