TWO SIGMA INVESTMENTS, LP Q4 2021 Filing

Filed February 14, 2022

Portfolio Value

$46.8M

Holdings

2,833

Report Date

Q4 2021

Filing Type

13F-HR

All Holdings (2,833 positions)

#	Stock	Shares	Value	% Portfolio	Type
901	LSEALANDSEA HOMES CORP	42,300	$310K	0.66%
902	WNEBWESTERN NEW ENG BANCORP INC	35,435	$310K	0.66%
903	DAREDARE BIOSCIENCE INC	155,128	$310K	0.66%
904	—9 METERS BIOPHARMA INC	316,480	$310K	0.66%
905	EEFTEURONET WORLDWIDE INC	2,603	$310K	0.66%
906	CDEVEURCENTENNIAL RESOURCE DEV INC	3,873,769	$309K	0.66%	Put
907	GTXIEURONCTERNAL THERAPEUTICS INC	135,859	$308K	0.66%
908	U6ZURANIUM ENERGY CORP	91,958	$308K	0.66%
909	HPKHIGHPEAK ENERGY INC	20,935	$306K	0.65%
910	TALKTALKSPACE INC	155,481	$306K	0.65%
911	AGLEUSDAEGLEA BIOTHERAPEUTICS INC	64,511	$306K	0.65%
912	IPHAINNATE PHARMA S A	67,055	$306K	0.65%
913	GNSSGENASYS INC	76,329	$304K	0.65%
914	TECK/BTECK RESOURCES LTD	10,500	$303K	0.65%	Put
915	DISHDISH NETWORK CORPORATION	332,900	$303K	0.65%	Put
916	OPBKOP BANCORP	23,706	$302K	0.65%
917	BFCBANK FIRST CORP	4,177	$302K	0.65%
918	GLGLOBE LIFE INC	22,784	$302K	0.64%	Put
919	RITMNEW RESIDENTIAL INVT CORP	27,800	$298K	0.64%	Put
920	XHBSPDR SER TR	3,470	$298K	0.64%
921	RPRXROYALTY PHARMA PLC	160,775	$297K	0.63%	Put
922	EGHT8X8 INC NEW	17,695	$297K	0.63%
923	JNJJOHNSON & JOHNSON	1,732,505	$296K	0.63%	Put
924	—CONTEXTLOGIC INC	5,377,202	$295K	0.63%	Put
925	PODDINSULET CORP	6,700	$294K	0.63%	Put
926	PLUSEPLUS INC	5,415	$292K	0.62%
927	CHUYUSDCHUYS HLDGS INC	9,682	$292K	0.62%
928	USLMUNITED STS LIME & MINERALS I	2,266	$292K	0.62%
929	FSTRFOSTER L B CO	21,133	$291K	0.62%
930	UTMUTAH MED PRODS INC	2,899	$290K	0.62%
931	PFEPFIZER INC	4,906,628	$290K	0.62%	Put
932	—SONO GROUP N V	30,031	$289K	0.62%
933	—TEAM INC	265,035	$289K	0.62%
934	HCWBHCW BIOLOGICS INC	124,705	$289K	0.62%
935	BNSBANK NOVA SCOTIA B C	4,000	$287K	0.61%	Call
936	HLLYHOLLEY INC	22,053	$286K	0.61%
937	IFRXINFLARX NV	60,169	$286K	0.61%
938	CNCEEURCONCERT PHARMACEUTICALS INC	90,900	$286K	0.61%
939	VVISA INC	1,318,195	$286K	0.61%	Put
940	FIXXEURHOMOLOGY MEDICINES INC	78,335	$285K	0.61%
941	CTHRUSDCHARLES & COLVARD LTD	98,231	$284K	0.61%
942	CRKCOMSTOCK RES INC	1,571,463	$282K	0.60%	Put
943	GYRECATALYST BIOSCIENCES INC	308,552	$282K	0.60%
944	AMDADVANCED MICRO DEVICES INC	1,958,829	$282K	0.60%	Put
945	VAC2USDVBI VACCINES INC CDA	119,200	$279K	0.60%
946	AZULQAZUL S A	21,100	$278K	0.59%	Put
947	KOCOCA COLA CO	4,685,086	$277K	0.59%	Put
948	ORGNORIGIN MATERIALS INC	42,999	$277K	0.59%
949	TRVCCITIGROUP INC	4,557,136	$275K	0.59%	Put
950	IPIINTREPID POTASH INC	6,440	$275K	0.59%
951	S76STORE CAP CORP	8,000	$275K	0.59%	Put
952	ABNBAIRBNB INC	1,646,922	$274K	0.59%	Put
953	ABBVABBVIE INC	2,023,946	$274K	0.59%	Put
954	AINALBANY INTL CORP	3,098	$274K	0.59%
955	LITELUMENTUM HLDGS INC	187,754	$274K	0.58%	Put
956	BWABORGWARNER INC	62,609	$274K	0.58%	Put
957	ADNTADIENT PLC	5,700	$273K	0.58%	Put
958	NFLXNETFLIX INC	452,104	$272K	0.58%	Put
959	HURNHURON CONSULTING GROUP INC	5,449	$272K	0.58%
960	ENOVCOLFAX CORP	5,910	$272K	0.58%
961	—ANGION BIOMEDICA CORP	93,935	$272K	0.58%
962	TELTE CONNECTIVITY LTD	186,104	$272K	0.58%	Call
963	—THE REAL GOOD FOOD COMPANY I	43,859	$271K	0.58%
964	XLUSELECT SECTOR SPDR TR	71,210	$271K	0.58%	Put
965	PFMTUSDPERFORMANT FINL CORP	111,945	$270K	0.58%
966	—OSMOTICA PHARMACEUTICALS PLC	249,851	$270K	0.58%
967	—DATCHAT INC	89,272	$270K	0.58%
968	RPCP10 INC	19,283	$270K	0.58%
969	NVDANVIDIA CORPORATION	913,961	$269K	0.57%	Put
970	HDHOME DEPOT INC	643,628	$267K	0.57%	Put
971	DHID R HORTON INC	49,213	$267K	0.57%	Put
972	METAMETA PLATFORMS INC	793,519	$267K	0.57%	Put
973	CATCATERPILLAR INC	1,290,316	$267K	0.57%	Put
974	BMYBRISTOL-MYERS SQUIBB CO	4,266,901	$266K	0.57%	Put
975	HONHONEYWELL INTL INC	1,272,928	$265K	0.57%	Put
976	LCLENDINGCLUB CORP	1,944,468	$265K	0.57%	Put
977	NBNNORTHEAST BK LEWISTON ME	7,400	$264K	0.56%
978	—VIVOS THERAPEUTICS INC	117,215	$264K	0.56%
979	NETCLOUDFLARE INC	2,005,161	$264K	0.56%	Put
980	XRXXEROX HOLDINGS CORP	1,926,820	$263K	0.56%	Put
981	—LANDOS BIOPHARMA INC	54,778	$263K	0.56%
982	ARRYARRAY TECHNOLOGIES INC	16,740	$263K	0.56%
983	HOWLWEREWOLF THERAPEUTICS INC	22,034	$262K	0.56%
984	LYTSLSI INDS INC OHIO	38,130	$262K	0.56%
985	OUTOUTFRONT MEDIA INC	9,771	$262K	0.56%
986	CHTRCHARTER COMMUNICATIONS INC N	401,138	$262K	0.56%	Put
987	DDOGDATADOG INC	1,468,100	$261K	0.56%	Put
988	LMTLOCKHEED MARTIN CORP	735,202	$261K	0.56%	Put
989	TCBXTHIRD COAST BANCSHARES INC	10,053	$261K	0.56%
990	CABACABALETTA BIO INC	68,567	$260K	0.56%
991	—ALFI INC	112,418	$259K	0.55%
992	FETFORUM ENERGY TECHNOLOGIES IN	16,059	$258K	0.55%
993	CECOCECO ENVIRONMENTAL CORP	41,372	$258K	0.55%
994	DCBODOCEBO INC	3,800	$256K	0.55%
995	NHCNATIONAL HEALTHCARE CORP	3,756	$255K	0.54%
996	SBSISOUTHSIDE BANCSHARES INC	6,106	$255K	0.54%
997	APLTAPPLIED THERAPEUTICS INC	28,431	$254K	0.54%
998	EPIEURESSA PHARMA INC	17,800	$253K	0.54%
999	—DOMA HOLDINGS INC	49,799	$253K	0.54%
1000	XIFRNEXTERA ENERGY PARTNERS LP	3,000	$253K	0.54%	Put

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