| 1 | BVF INC/IL | 19,822,436 | $62.2M | 2.10% | Share |
| 2 | WELLS FARGO & COMPANY/MN | 1,005,289 | $3.0M | 0.00% | Share |
| 3 | RENAISSANCE TECHNOLOGIES LLC | 668,867 | $2.0M | 0.00% | Share |
| 4 | MILLENNIUM MANAGEMENT LLC | 933,342 | $2.0M | 0.00% | Share |
| 5 | BlackRock, Inc. | 427,229 | $1.0M | 0.00% | Share |
| 6 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 375,623 | $1.0M | 0.00% | Share |
| 7 | ACADIAN ASSET MANAGEMENT LLC | 464,697 | $1.0M | 0.00% | Share |
| 8 | Point72 Asset Management, L.P. | 384,845 | $1.0M | 0.00% | Share |
| 9 | GROUP ONE TRADING LLC | 199,000 | $624K | 0.00% | Call |
| 10 | UBS Group AG | 188,349 | $591K | 0.00% | Share |
| 11 | Dauntless Investment Group, LLC | 115,677 | $363K | 0.29% | Share |
| 12 | China Universal Asset Management Co., Ltd. | 16,362 | $51K | 0.00% | Share |
| 13 | Silverberg Bernstein Capital Management LLC | 10,000 | $31K | 0.02% | Share |
| 14 | Quinn Opportunity Partners LLC | 10,100 | $31K | 0.00% | Share |
| 15 | UBS Group AG | 6,000 | $18K | 0.00% | Share |
| 16 | Mirae Asset Global Investments Co., Ltd. | 4,879 | $15K | 0.00% | Share |
| 17 | GF FUND MANAGEMENT CO. LTD. | 1,972 | $6K | 0.00% | Share |
| 18 | Activest Wealth Management | 1,000 | $3K | 0.00% | Share |
| 19 | SBI Securities Co., Ltd. | 547 | $1K | 0.00% | Share |
| 20 | DIMENSIONAL FUND ADVISORS LP | 50,996 | $0 | 0.00% | Share |
| 21 | GOLDMAN SACHS GROUP INC | 18,555 | $0 | 0.00% | Share |
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 63,601 | $0 | 0.00% | Share |
| 23 | MARSHALL WACE, LLP | 17,638 | $0 | 0.00% | Share |
| 24 | MARSHALL WACE, LLP | 169,071 | $0 | 0.00% | Share |
| 25 | ROYAL BANK OF CANADA | 760 | $0 | 0.00% | Share |
| 26 | ROYAL BANK OF CANADA | 98 | $0 | 0.00% | Share |
| 27 | TWO SIGMA INVESTMENTS, LP | 87,884 | $0 | 0.00% | Share |
| 28 | CITADEL ADVISORS LLC | 45,335 | $0 | 0.00% | Share |
| 29 | CITADEL ADVISORS LLC | 50,500 | $0 | 0.00% | Call |
| 30 | CITADEL ADVISORS LLC | 25,816 | $0 | 0.00% | Share |
| 31 | CITADEL ADVISORS LLC | 11,400 | $0 | 0.00% | Put |
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,139 | $0 | 0.00% | Share |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 132,486 | $0 | 0.00% | Share |
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,400 | $0 | 0.00% | Call |
| 35 | Tower Research Capital LLC (TRC) | 3,626 | $0 | 0.00% | Share |
| 36 | Tower Research Capital LLC (TRC) | 2,540 | $0 | 0.00% | Share |
| 37 | BANK OF AMERICA CORP /DE/ | 17,191 | $0 | 0.00% | Share |
| 38 | BANK OF AMERICA CORP /DE/ | 4,280 | $0 | 0.00% | Share |
| 39 | NORTHERN TRUST CORP | 281,953 | $0 | 0.00% | Share |
| 40 | BNP PARIBAS FINANCIAL MARKETS | 2,480 | $0 | 0.00% | Share |
| 41 | SEI INVESTMENTS CO | 15,884 | $0 | 0.00% | Share |
| 42 | MORGAN STANLEY | 72,310 | $0 | 0.00% | Share |
| 43 | MORGAN STANLEY | 13,614 | $0 | 0.00% | Share |
| 44 | MORGAN STANLEY | 7,924 | $0 | 0.00% | Share |
| 45 | MORGAN STANLEY | 415 | $0 | 0.00% | Share |
| 46 | MORGAN STANLEY | 82 | $0 | 0.00% | Share |
| 47 | BlackRock, Inc. | 4,018 | $0 | 0.00% | Share |
| 48 | BlackRock, Inc. | 70,922 | $0 | 0.00% | Share |
| 49 | JPMORGAN CHASE & CO | 8,721 | $0 | 0.00% | Share |
| 50 | BARCLAYS PLC | 2,701 | $0 | 0.00% | Share |