Who Owns Annexon, Inc. (ANNX)?Hedge Fund & Institutional Holders

$5.64+0.20 (+3.77%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$5.045445822344143e+213T

% of Float Held

Infinity%

QoQ Change in Holders

+14 / -4

Price History

$1.38$2.94$4.50$6.07$7.63Sep 24Jun 25Mar 26

ANNX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Longaeva Partners L.P.New Position+3.1M+$15.6M
MAK CAPITAL ONE LLCNew Position+3.0M+$14.9M
Palo Alto Investors LPNew Position+2.4M+$12.0M
MASSACHUSETTS FINANCIAL SERVICES CO /MA/New Position+903K+$4.5M
D. E. Shaw & Co., Inc.New Position+1.0M+$4.0M
Ishara Investments LPNew Position+750K+$3.8M
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCNew Position+642K+$3.0M
Hennion & Walsh Asset Management, Inc.New Position+535K+$2.7M
Board of Trustees of The Leland Stanford Junior UniversityNew Position+483K+$2.4M
ACADIAN ASSET MANAGEMENT LLCIncreased+329K+$2.4M
MARSHALL WACE, LLPNew Position+521K+$2.0M
DIADEMA PARTNERS LPNew Position+350K+$1.8M
DAFNA Capital Management LLCNew Position+273K+$1.4M
Ikarian Capital, LLCNew Position+230K+$1.2M
Bank of New York Mellon CorpNew Position+362K+$1.0M

ANNX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
FMR LLCDecreased-859K-$33.7B
MORGAN STANLEYDecreased-174K-$9.2B
Candriam S.C.A.Closed Position-2.5M-$7.7B
GOLDMAN SACHS GROUP INCDecreased-638K-$7.3B
Tetragon Partners GP LtdDecreased-80K-$6.4B
SPHERA FUNDS MANAGEMENT LTD.Decreased-478K-$5.5B
DEUTSCHE BANK AG\Decreased-944K-$4.6B
J. Goldman & Co LPDecreased-113K-$3.4B
SIRIOS CAPITAL MANAGEMENT L PDecreased-260K-$3.0B
Rhenman & Partners Asset Management ABClosed Position-823K-$2.5B
DIMENSIONAL FUND ADVISORS LPDecreased-48K-$2.3B
KENNEDY CAPITAL MANAGEMENT LLCDecreased-558-$2.0B
Point72 Europe (London) LLPClosed Position-303K-$923.7M
ROYAL BANK OF CANADADecreased-283K-$871.0M
ExodusPoint Capital Management, LPClosed Position-244K-$743.5M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Redmile Group, LLC10,050,644$50.5M3.72%Share
2BVF INC/IL9,128,080$45.8M1.54%Share
3VANGUARD GROUP INC6,855,389$34.4M0.00%Share
4FMR LLC6,675,271$33.0M0.00%Share
5ADAGE CAPITAL PARTNERS GP, L.L.C.5,500,000$27.0M0.04%Share
6Bain Capital Life Sciences Investors, LLC5,249,069$26.4M2.02%Share
7Bellevue Group AG5,157,290$25.9M0.49%Share
8BlackRock, Inc.4,806,593$24.0M0.00%Share
9STATE STREET CORP4,652,185$23.0M0.00%Share
10AMERIPRISE FINANCIAL INC4,272,901$21.0M0.00%Share
11Woodline Partners LP4,000,074$20.0M0.08%Share
12BlackRock, Inc.3,443,593$17.0M0.00%Share
13BALYASNY ASSET MANAGEMENT L.P.3,299,256$16.0M0.02%Share
14Longaeva Partners L.P.3,100,000$15.6M1.31%Share
15MAK CAPITAL ONE LLC2,958,527$14.9M1.63%Share
16MILLENNIUM MANAGEMENT LLC2,836,857$14.0M0.01%Share
17Opaleye Management Inc.2,600,000$13.1M1.72%Share
18FMR LLC2,651,520$13.0M0.00%Share
19GEODE CAPITAL MANAGEMENT, LLC2,491,447$12.0M0.00%Share
20Palo Alto Investors LP2,384,192$12.0M1.67%Share
21Qube Research & Technologies Ltd2,381,479$11.0M0.01%Share
22Tetragon Partners GP Ltd2,032,455$10.2M2.15%Share
23MORGAN STANLEY2,074,742$10.0M0.00%Share
24Nuveen, LLC1,499,900$7.0M0.00%Share
25Nuveen, LLC1,401,740$7.0M0.00%Share
26BANK OF AMERICA CORP /DE/1,520,148$7.0M0.00%Share
27SPHERA FUNDS MANAGEMENT LTD.1,316,212$6.6M1.28%Share
28GOLDMAN SACHS GROUP INC1,213,783$6.0M0.00%Share
29CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,057,060$5.0M0.00%Share
30J. Goldman & Co LP993,795$5.0M0.13%Share
31Invesco Ltd.942,422$4.7M0.00%Share
32MASSACHUSETTS FINANCIAL SERVICES CO /MA/903,439$4.5M0.00%Share
33VANGUARD GROUP INC843,944$4.2M0.00%Share
34FMR LLC895,607$4.0M0.00%Share
35ACADIAN ASSET MANAGEMENT LLC861,245$4.0M0.01%Share
36RENAISSANCE TECHNOLOGIES LLC802,600$4.0M0.01%Share
37D. E. Shaw & Co., Inc.963,617$4.0M0.00%Share
38Ishara Investments LP750,000$3.8M4.31%Share
39SIRIOS CAPITAL MANAGEMENT L P710,256$3.6M0.44%Share
40KENNEDY CAPITAL MANAGEMENT LLC639,902$3.2M0.07%Share
41Parkman Healthcare Partners LLC601,202$3.0M0.29%Share
42AQR CAPITAL MANAGEMENT LLC761,168$3.0M0.00%Share
43DIMENSIONAL FUND ADVISORS LP650,584$3.0M0.00%Share
44NORTHERN TRUST CORP771,761$3.0M0.00%Share
45MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC642,038$3.0M0.03%Share
46JACOBS LEVY EQUITY MANAGEMENT, INC683,879$3.0M0.01%Share
47DEERFIELD MANAGEMENT COMPANY, L.P.583,913$2.9M0.04%Share
48Hennion & Walsh Asset Management, Inc.534,986$2.7M0.09%Share
49Schonfeld Strategic Advisors LLC522,846$2.6M0.01%Share
50Board of Trustees of The Leland Stanford Junior University482,550$2.4M0.49%Share

ANNX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025165$645.4M+47
Q3 2025118$293.8B+13
Q2 2025105$208.4B-43
Q1 2025148$189.5B-2
Q4 2024150$2.8T+26
Q3 2024124$370.0T+2
Q2 2024122$259.6T+10
Q1 2024112$387.5T—

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As of Q4 2025, 50 institutional investors hold ANNX (Annexon, Inc.). The largest holder is Redmile Group, LLC with $50.5M in shares. This quarter, 14 institutions opened new positions and 4 closed their positions.

Frequently Asked Questions

How many hedge funds own ANNX?

As of Q4 2025, 50 institutional investors report holding ANNX (Annexon, Inc.) in their 13F filings.

Who is the largest institutional holder of ANNX?

The largest institutional holder of ANNX is Redmile Group, LLC with $50.5M in shares.

Is institutional ownership of ANNX increasing or decreasing?

This quarter, 14 institutions opened new positions in ANNX and 4 closed their positions.