| 1 | BAKER BROS. ADVISORS LP | 10,885,357 | $77.1M | 0.45% | Share |
| 2 | FCPM III SERVICES B.V. | 3,468,430 | $24.6M | 3.22% | Share |
| 3 | ARMISTICE CAPITAL, LLC | 3,236,000 | $22.9M | 0.27% | Share |
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 3,016,026 | $21.0M | 0.09% | Share |
| 5 | Siren, L.L.C. | 2,012,752 | $14.3M | 0.43% | Share |
| 6 | Long Focus Capital Management, LLC | 1,633,091 | $11.6M | 0.30% | Share |
| 7 | ACADIAN ASSET MANAGEMENT LLC | 1,671,258 | $11.0M | 0.02% | Share |
| 8 | GSK plc | 1,529,561 | $10.8M | 1.36% | Share |
| 9 | PRINCIPAL FINANCIAL GROUP INC | 1,148,272 | $8.1M | 0.00% | Share |
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,171,787 | $8.0M | 0.00% | Share |
| 11 | Candriam S.C.A. | 1,192,279 | $8.0M | 0.04% | Share |
| 12 | BNP Paribas Asset Management Holding S.A. | 568,225 | $4.0M | 0.00% | Share |
| 13 | RENAISSANCE TECHNOLOGIES LLC | 566,600 | $4.0M | 0.01% | Share |
| 14 | Birchview Capital, LP | 462,700 | $3.3M | 1.92% | Share |
| 15 | SILVERCREST ASSET MANAGEMENT GROUP LLC | 476,976 | $3.0M | 0.02% | Share |
| 16 | SCHRODER INVESTMENT MANAGEMENT GROUP | 584,770 | $3.0M | 0.00% | Share |
| 17 | Jefferies Financial Group Inc. | 297,247 | $2.0M | 0.01% | Share |
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 300,000 | $2.0M | 0.00% | Call |
| 19 | MILLENNIUM MANAGEMENT LLC | 326,626 | $2.0M | 0.00% | Share |
| 20 | MORGAN STANLEY | 309,836 | $2.0M | 0.00% | Share |
| 21 | MOORE CAPITAL MANAGEMENT, LP | 275,000 | $1.9M | 0.03% | Share |
| 22 | Palo Alto Investors LP | 221,071 | $1.6M | 0.22% | Share |
| 23 | PINNACLE ASSOCIATES LTD | 190,480 | $1.3M | 0.02% | Share |
| 24 | Eversept Partners, LP | 178,915 | $1.3M | 0.06% | Share |
| 25 | PLATINUM INVESTMENT MANAGEMENT LTD | 184,603 | $1.0M | 0.23% | Share |
| 26 | BlackRock, Inc. | 248,713 | $1.0M | 0.00% | Share |
| 27 | TD ASSET MANAGEMENT INC | 147,992 | $1.0M | 0.00% | Share |
| 28 | CITADEL ADVISORS LLC | 266,154 | $1.0M | 0.00% | Share |
| 29 | TWO SIGMA ADVISERS, LP | 146,100 | $1.0M | 0.00% | Share |
| 30 | FIDEURAM - INTESA SANPAOLO PRIVATE BANKING S.P.A. | 134,689 | $953K | 0.03% | Share |
| 31 | Rangeley Capital, LLC | 132,000 | $934K | 0.78% | Share |
| 32 | DekaBank Deutsche Girozentrale | 30,000 | $801K | 0.00% | Share |
| 33 | MONIMUS CAPITAL MANAGEMENT, LP | 93,840 | $664K | 0.44% | Share |
| 34 | Nan Fung Group Holdings Ltd | 68,943 | $488K | 0.44% | Share |
| 35 | DAFNA Capital Management LLC | 64,492 | $456K | 0.11% | Share |
| 36 | HARBOR CAPITAL ADVISORS, INC. | 40,486 | $287K | 0.02% | Share |
| 37 | Virtus Investment Advisers, LLC | 35,709 | $252K | 0.07% | Share |
| 38 | WOODSTOCK CORP | 29,146 | $206K | 0.02% | Share |
| 39 | State of New Jersey Common Pension Fund D | 20,105 | $142K | 0.00% | Share |
| 40 | Leonteq Securities AG | 5,000 | $124K | 0.01% | Share |
| 41 | UBS Group AG | 15,778 | $111K | 0.00% | Share |
| 42 | PORTLAND INVESTMENT COUNSEL INC. | 15,000 | $106K | 0.03% | Share |
| 43 | HORIZON KINETICS ASSET MANAGEMENT LLC | 13,792 | $97K | 0.00% | Share |
| 44 | Forefront Analytics, LLC | 13,371 | $94K | 0.08% | Share |
| 45 | Leonteq Securities AG | 5,000 | $90K | 0.01% | Share |
| 46 | Crossmark Global Holdings, Inc. | 11,399 | $80K | 0.00% | Share |
| 47 | Invesco Ltd. | 10,092 | $71K | 0.00% | Share |
| 48 | Pinnacle Wealth Management Advisory Group, LLC | 10,000 | $70K | 0.00% | Share |
| 49 | FNY Investment Advisers, LLC | 7,486 | $53K | 0.01% | Share |
| 50 | China Universal Asset Management Co., Ltd. | 7,540 | $53K | 0.00% | Share |