| 1 | Darwin Global Management, Ltd. | 3,027,704 | $486.9M | 9.86% | Share |
| 2 | RTW INVESTMENTS, LP | 715,332 | $114.4M | 1.15% | Share |
| 3 | MILLENNIUM MANAGEMENT LLC | 558,882 | $89.0M | 0.04% | Share |
| 4 | RA CAPITAL MANAGEMENT, L.P. | 432,484 | $69.2M | 0.71% | Share |
| 5 | PERCEPTIVE ADVISORS LLC | 414,239 | $66.3M | 1.18% | Share |
| 6 | EVENTIDE ASSET MANAGEMENT, LLC | 383,091 | $61.3M | 0.96% | Share |
| 7 | Point72 Asset Management, L.P. | 284,437 | $45.0M | 0.05% | Share |
| 8 | DEERFIELD MANAGEMENT COMPANY, L.P. | 233,813 | $37.4M | 0.48% | Share |
| 9 | MARSHALL WACE, LLP | 161,250 | $25.0M | 0.02% | Share |
| 10 | UBS Group AG | 94,147 | $15.1M | 0.00% | Share |
| 11 | MPM BioImpact LLC | 87,760 | $14.0M | 1.61% | Share |
| 12 | Holocene Advisors, LP | 84,067 | $13.0M | 0.03% | Share |
| 13 | FRED ALGER MANAGEMENT, LLC | 79,394 | $12.0M | 0.05% | Share |
| 14 | Western Standard LLC | 60,026 | $9.6M | 4.43% | Share |
| 15 | GOLDMAN SACHS GROUP INC | 44,599 | $7.0M | 0.00% | Share |
| 16 | Soleus Capital Management, L.P. | 40,354 | $6.5M | 0.24% | Share |
| 17 | ADAR1 Capital Management, LLC | 39,839 | $6.4M | 0.46% | Share |
| 18 | UBS Group AG | 34,452 | $5.5M | 0.00% | Share |
| 19 | Squadron Capital Management LLC | 26,000 | $4.2M | 1.76% | Share |
| 20 | MARSHALL WACE, LLP | 31,250 | $4.0M | 0.00% | Share |
| 21 | SUPERSTRING CAPITAL MANAGEMENT LP | 24,703 | $4.0M | 2.12% | Share |
| 22 | Affinity Asset Advisors, LLC | 20,000 | $3.2M | 0.18% | Share |
| 23 | PFM Health Sciences, LP | 19,823 | $3.2M | 0.32% | Share |
| 24 | JANE STREET GROUP, LLC | 23,888 | $3.0M | 0.00% | Share |
| 25 | Artia Global Partners LP | 17,989 | $2.9M | 0.41% | Share |
| 26 | Exome Asset Management LLC | 14,328 | $2.3M | 1.10% | Share |
| 27 | STATE STREET CORP | 15,740 | $2.0M | 0.00% | Share |
| 28 | Woodline Partners LP | 18,041 | $2.0M | 0.01% | Share |
| 29 | BANK OF MONTREAL /CAN/ | 15,538 | $2.0M | 0.00% | Share |
| 30 | MORGAN STANLEY | 16,323 | $2.0M | 0.00% | Share |
| 31 | STEMPOINT CAPITAL LP | 9,163 | $1.5M | 0.25% | Share |
| 32 | HRT FINANCIAL LP | 8,164 | $1.0M | 0.00% | Share |
| 33 | JANE STREET GROUP, LLC | 8,430 | $1.0M | 0.00% | Share |
| 34 | BOOTHBAY FUND MANAGEMENT, LLC | 11,897 | $1.0M | 0.01% | Share |
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 10,445 | $1.0M | 0.00% | Share |
| 36 | AMERIPRISE FINANCIAL INC | 10,329 | $1.0M | 0.00% | Share |
| 37 | MORGAN STANLEY | 7,236 | $1.0M | 0.00% | Share |
| 38 | High Net Worth Advisory Group LLC | 3,500 | $559K | 0.13% | Share |
| 39 | PSP Research LLC | 3,443 | $550K | 0.48% | Share |
| 40 | Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 3,049 | $487K | 0.07% | Share |
| 41 | SG Americas Securities, LLC | 2,755 | $441K | 0.00% | Share |
| 42 | Yeomans Consulting Group, Inc. | 2,399 | $383K | 0.11% | Share |
| 43 | Virtus Investment Advisers, LLC | 1,882 | $301K | 0.08% | Share |
| 44 | GAMMA Investing LLC | 1,779 | $284K | 0.01% | Share |
| 45 | Independent Advisor Alliance | 1,319 | $210K | 0.01% | Share |
| 46 | EverSource Wealth Advisors, LLC | 1,275 | $203K | 0.01% | Share |
| 47 | Persistent Asset Partners Ltd | 673 | $107K | 0.05% | Share |
| 48 | Mirae Asset Global Investments Co., Ltd. | 645 | $103K | 0.00% | Share |
| 49 | China Universal Asset Management Co., Ltd. | 500 | $79K | 0.01% | Share |
| 50 | EverSource Wealth Advisors, LLC | 323 | $51K | 0.00% | Share |