Who Owns Castle Biosciences, Inc. (CSTL)?Hedge Fund & Institutional Holders

$25.87+0.31 (+1.21%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

7.202971638050178e+280%

QoQ Change in Holders

+7 / -3

Price History

$14.65$21.75$28.84$35.94$43.04Sep 24Jun 25Mar 26

CSTL — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
PRINCIPAL FINANCIAL GROUP INCNew Position+1.8M+$70.3B
Portolan Capital Management, LLCIncreased+214K+$32.8B
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLCIncreased+659K+$32.1B
AIGH Capital Management LLCNew Position+625K+$24.3B
Allianz Asset Management GmbHNew Position+622K+$23.0B
EVENTIDE ASSET MANAGEMENT, LLCNew Position+305K+$11.9B
KORNITZER CAPITAL MANAGEMENT INC /KSNew Position+268K+$10.4B
NEW YORK STATE COMMON RETIREMENT FUNDNew Position+233K+$9.0B
CITADEL ADVISORS LLCIncreased+115K+$8.3B
Connor, Clark & Lunn Investment Management Ltd.Increased+53K+$7.4B
WELLINGTON MANAGEMENT GROUP LLPNew Position+219K+$7.0B
BRIDGEWAY CAPITAL MANAGEMENT, LLCIncreased+70K+$5.0B
Invesco Ltd.Increased+80K+$4.0B
D. E. Shaw & Co., Inc.Increased+67K+$3.9B
CHARLES SCHWAB INVESTMENT MANAGEMENT INCIncreased+4K+$3.6B

CSTL — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Advisors Capital Management, LLCDecreased-4K-$5.8B
AMERIPRISE FINANCIAL INCDecreased-221K-$4.8B
Trexquant Investment LPDecreased-114K-$4.1B
Point72 Asset Management, L.P.Decreased-218K-$3.7B
Nuveen, LLCDecreased-432K-$2.8B
Schonfeld Strategic Advisors LLCDecreased-66K-$2.0B
SILVERCREST ASSET MANAGEMENT GROUP LLCDecreased-163K-$1.4B
Cubist Systematic Strategies, LLCClosed Position-50K-$1.1B
UBS Group AGDecreased-149K-$1.1B
MILLENNIUM MANAGEMENT LLCDecreased-266K-$1.1B
Engineers Gate Manager LPDecreased-24K-$1.1B
TRITONPOINT WEALTH, LLCClosed Position-41K-$928.5M
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUNDClosed Position-36K-$815.2M
Legal & General Group PlcDecreased-5K-$794.9M
ALLIANCEBERNSTEIN L.P.Decreased-8K-$759.8M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1PRINCIPAL FINANCIAL GROUP INC1,806,423$70.3B35.88%Share
2Portolan Capital Management, LLC1,729,463$67.3B3.60%Share
3DIMENSIONAL FUND ADVISORS LP1,101,177$42.0B8.81%Share
4SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC1,058,725$41.2B0.86%Share
5Allianz Asset Management GmbH597,961$23.0B23.26%Share
6PALISADE CAPITAL MANAGEMENT, LP567,777$22.1B0.65%Share
7WASATCH ADVISORS LP537,241$20.9B124.17%Share
8RENAISSANCE TECHNOLOGIES LLC493,100$19.0B29.48%Share
9SCHRODER INVESTMENT MANAGEMENT GROUP492,161$19.0B14.40%Share
10AIGH Capital Management LLC455,443$17.7B4.29%Share
11Connor, Clark & Lunn Investment Management Ltd.388,491$15.0B39.34%Share
12MILLENNIUM MANAGEMENT LLC308,914$12.0B5.05%Share
13EVENTIDE ASSET MANAGEMENT, LLC305,000$11.9B185.33%Share
14KORNITZER CAPITAL MANAGEMENT INC /KS267,733$10.4B0.22%Share
15Nuveen, LLC280,938$10.0B2.62%Share
16CHARLES SCHWAB INVESTMENT MANAGEMENT INC242,535$9.0B1.40%Share
17BRIDGEWAY CAPITAL MANAGEMENT, LLC246,920$9.0B0.19%Share
18NEW YORK STATE COMMON RETIREMENT FUND233,046$9.0B12.01%Share
19BANK OF AMERICA CORP /DE/239,430$9.0B0.65%Share
20NORTHERN TRUST CORP231,146$8.0B1.02%Share
21CITADEL ADVISORS LLC208,125$8.0B1.20%Share
22SILVERCREST ASSET MANAGEMENT GROUP LLC205,002$7.0B48.11%Share
23AIGH Capital Management LLC169,276$6.6B1.59%Share
24CITADEL ADVISORS LLC158,231$6.0B0.90%Share
25GOLDMAN SACHS GROUP INC160,847$6.0B0.74%Share
26D. E. Shaw & Co., Inc.159,709$6.0B3.29%Share
27UBS Group AG140,266$5.5B0.88%Share
28Nuveen, LLC134,841$5.0B1.31%Share
29Invesco Ltd.119,176$4.6B0.71%Share
30Nuveen, LLC108,902$4.0B1.05%Share
31GOLDMAN SACHS GROUP INC126,388$4.0B0.49%Share
32WELLINGTON MANAGEMENT GROUP LLP125,160$4.0B0.70%Share
33Point72 Asset Management, L.P.119,458$4.0B4.47%Share
34Birchview Capital, LP80,600$3.1B1.84%Share
35FRANKLIN RESOURCES INC77,576$3.0B0.74%Share
36TWO SIGMA INVESTMENTS, LP84,066$3.0B4.23%Share
37AMERICAN CENTURY COMPANIES INC77,768$3.0B1.51%Share
38BARCLAYS PLC72,128$2.0B0.48%Share
39Swiss National Bank57,300$2.0B1.19%Share
40AQR CAPITAL MANAGEMENT LLC62,696$2.0B1.05%Share
41Orion Porfolio Solutions, LLC74,653$2.0B14.67%Share
42JPMORGAN CHASE & CO71,488$2.0B0.13%Share
43WELLINGTON MANAGEMENT GROUP LLP62,382$2.0B0.35%Share
44Universal- Beteiligungs- und Servicegesellschaft mbH29,357$1.1B1.85%Share
45TWO SIGMA ADVISERS, LP29,899$1.0B1.94%Share
46WELLS FARGO & COMPANY/MN31,851$1.0B0.18%Share
47SEI INVESTMENTS CO32,859$1.0B0.99%Share
48RHUMBLINE ADVISERS38,468$1.0B0.81%Share
49OSAIC HOLDINGS, INC.36,404$1.0B1.46%Share
50FMR LLC42,284$1.0B0.05%Share

CSTL Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025192$561.6B+61
Q3 2025131$288.7B+0
Q2 2025131$278.9B-48
Q1 2025179$413.1B-10
Q4 2024189$1.1T+37
Q3 2024152$23.8T+23
Q2 2024129$18.2T+2
Q1 2024127$8.3T—

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As of Q4 2025, 50 institutional investors hold CSTL (Castle Biosciences, Inc.). The largest holder is PRINCIPAL FINANCIAL GROUP INC with $70.3B in shares. This quarter, 7 institutions opened new positions and 3 closed their positions.

Frequently Asked Questions

How many hedge funds own CSTL?

As of Q4 2025, 50 institutional investors report holding CSTL (Castle Biosciences, Inc.) in their 13F filings.

Who is the largest institutional holder of CSTL?

The largest institutional holder of CSTL is PRINCIPAL FINANCIAL GROUP INC with $70.3B in shares.

Is institutional ownership of CSTL increasing or decreasing?

This quarter, 7 institutions opened new positions in CSTL and 3 closed their positions.