Who Owns Denali Therapeutics Inc. (DNLI)?Hedge Fund & Institutional Holders

$20.61-0.09 (-0.43%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+5 / -5

Price History

$11.47$16.50$21.52$26.55$31.58Sep 24Jun 25Mar 26

DNLI — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
BAILLIE GIFFORD & CONew Position+12.3M+$203.3B
Temasek Holdings (Private) LtdIncreased+1.7M+$37.2B
GOLDMAN SACHS GROUP INCIncreased+1.7M+$30.6B
PRINCIPAL FINANCIAL GROUP INCNew Position+1.5M+$25.2B
Lynx1 Capital Management LPIncreased+1.5M+$24.9B
Fisher Asset Management, LLCIncreased+958K+$18.3B
Casdin Capital, LLCIncreased+950K+$17.5B
Aberdeen Group plcIncreased+919K+$17.4B
ExodusPoint Capital Management, LPNew Position+1.0M+$16.0B
Alyeska Investment Group, L.P.New Position+859K+$14.0B
Siren, L.L.C.Increased+575K+$11.1B
UBS Group AGIncreased+392K+$10.5B
Vestal Point Capital, LPNew Position+465K+$7.7B
Candriam S.C.A.Increased+333K+$6.9B
ALLIANCEBERNSTEIN L.P.Increased+38K+$6.9B

DNLI — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Crestline Management, LPDecreased-600K-$49.5B
STEMPOINT CAPITAL LPDecreased-1.3M-$18.3B
VOLORIDGE INVESTMENT MANAGEMENT, LLCDecreased-345K-$13.6B
MILLENNIUM MANAGEMENT LLCDecreased-937K-$13.0B
MARSHALL WACE, LLPDecreased-23K-$11.4B
Point72 Asset Management, L.P.Decreased-820K-$8.6B
Capital Research Global InvestorsDecreased-1.0M-$8.1B
Yiheng Capital Management, L.P.Closed Position-470K-$6.8B
Trexquant Investment LPDecreased-221K-$6.2B
ROYAL BANK OF CANADADecreased-361K-$5.4B
AXA Investment Managers S.A.Closed Position-295K-$4.3B
Boxer Capital Management, LLCClosed Position-250K-$3.6B
Cubist Systematic Strategies, LLCClosed Position-231K-$3.4B
Schonfeld Strategic Advisors LLCClosed Position-226K-$3.3B
JANE STREET GROUP, LLCDecreased-182K-$3.3B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1BAILLIE GIFFORD & CO7,475,081$123.4B0.10%Share
2Temasek Holdings (Private) Ltd7,012,974$115.0B0.36%Share
3BAKER BROS. ADVISORS LP3,731,695$61.6B0.36%Share
4Capital Research Global Investors3,729,244$61.0B0.01%Share
5ALLIANCEBERNSTEIN L.P.3,557,935$58.0B0.02%Share
6BAILLIE GIFFORD & CO3,172,048$52.4B0.04%Share
7Holocene Advisors, LP3,152,734$52.0B0.11%Share
8FMR LLC2,726,832$45.0B0.00%Share
9Fisher Asset Management, LLC2,589,403$42.0B0.01%Share
10DIMENSIONAL FUND ADVISORS LP2,233,311$36.0B0.01%Share
11GOLDMAN SACHS GROUP INC2,076,231$34.0B0.00%Share
12Aberdeen Group plc2,032,967$33.6B0.05%Share
13FMR LLC2,051,083$33.0B0.00%Share
14Casdin Capital, LLC1,840,000$30.4B1.89%Share
15Lynx1 Capital Management LP1,738,750$28.7B5.81%Share
16Point72 Asset Management, L.P.1,700,000$28.0B0.03%Share
17GOLDMAN SACHS GROUP INC1,736,488$28.0B0.00%Share
18BAILLIE GIFFORD & CO1,532,727$25.3B0.02%Share
19PRINCIPAL FINANCIAL GROUP INC1,518,293$25.1B0.01%Share
20UBS Group AG1,429,610$23.6B0.00%Share
21Siren, L.L.C.1,396,513$23.1B0.69%Share
22CHARLES SCHWAB INVESTMENT MANAGEMENT INC1,200,475$19.0B0.00%Share
23Candriam S.C.A.1,166,379$19.0B0.09%Share
24NORTHERN TRUST CORP1,062,481$17.0B0.00%Share
25Foresite Capital Management VI LLC1,000,000$16.5B4.99%Share
26MASTERS CAPITAL MANAGEMENT LLC1,000,000$16.5B0.67%Share
27ExodusPoint Capital Management, LP1,023,253$16.0B0.13%Share
28FMR LLC976,860$16.0B0.00%Share
29UBS Group AG925,875$15.3B0.00%Share
30Alyeska Investment Group, L.P.859,108$14.0B0.04%Share
31CITADEL ADVISORS LLC739,206$12.0B0.00%Share
32BANK OF AMERICA CORP /DE/744,645$12.0B0.00%Share
33SEGALL BRYANT & HAMILL, LLC537,000$8.9B0.12%Share
34Ensign Peak Advisors, Inc515,721$8.0B0.01%Share
35Vestal Point Capital, LP465,000$7.7B0.26%Share
36SCHRODER INVESTMENT MANAGEMENT GROUP450,454$7.0B0.01%Share
37TWO SIGMA INVESTMENTS, LP430,177$7.0B0.01%Share
38STEMPOINT CAPITAL LP419,058$6.9B1.19%Share
39Clarius Group, LLC368,995$6.1B0.35%Share
40AMERICAN CENTURY COMPANIES INC379,051$6.0B0.00%Share
41BARCLAYS PLC407,264$6.0B0.00%Share
42MILLENNIUM MANAGEMENT LLC369,767$6.0B0.00%Share
43TD ASSET MANAGEMENT INC339,410$5.0B0.00%Share
44FMR LLC329,868$5.0B0.00%Share
45Marex Group plc287,000$4.0B0.03%Share
46Swiss National Bank273,800$4.0B0.00%Share
47Nuveen, LLC269,138$4.0B0.00%Share
48Invesco Ltd.210,250$3.5B0.00%Share
49Burkehill Global Management, LP200,000$3.3B0.22%Share
50SCS Capital Management LLC197,998$3.3B0.03%Share

DNLI Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025249$1.3T+60
Q3 2025189$877.2B-2
Q2 2025191$897.9B-31
Q1 2025222$1.2T+3
Q4 2024219$2.1T+37
Q3 2024182$187.2T+7
Q2 2024175$136.3T+6
Q1 2024169$981.4T—

Similar Stocks by Institutional Ownership

LLY

Eli Lilly and Company

JNJ

Johnson & Johnson

ABBV

AbbVie Inc.

NVS

Novartis AG

AZN

AstraZeneca PLC

MRK

Merck & Co., Inc.

UNH

UnitedHealth Group Incorporated

AMGN

Amgen Inc.

As of Q4 2025, 50 institutional investors hold DNLI (Denali Therapeutics Inc.). The largest holder is BAILLIE GIFFORD & CO with $123.4B in shares. This quarter, 5 institutions opened new positions and 5 closed their positions.

Frequently Asked Questions

How many hedge funds own DNLI?

As of Q4 2025, 50 institutional investors report holding DNLI (Denali Therapeutics Inc.) in their 13F filings.

Who is the largest institutional holder of DNLI?

The largest institutional holder of DNLI is BAILLIE GIFFORD & CO with $123.4B in shares.

Is institutional ownership of DNLI increasing or decreasing?

This quarter, 5 institutions opened new positions in DNLI and 5 closed their positions.