| 1 | Beutel, Goodman & Co Ltd. | 3,709,373 | $27.9M | 0.17% | Share |
| 2 | Vivo Capital, LLC | 1,350,000 | $10.2M | 0.66% | Share |
| 3 | BALYASNY ASSET MANAGEMENT L.P. | 1,350,000 | $10.0M | 0.01% | Share |
| 4 | GREAT POINT PARTNERS LLC | 1,200,000 | $9.1M | 2.94% | Share |
| 5 | SCOTIA CAPITAL INC. | 1,286,183 | $9.0M | 0.04% | Share |
| 6 | Point72 Asset Management, L.P. | 712,104 | $5.0M | 0.01% | Share |
| 7 | Ikarian Capital, LLC | 610,000 | $4.6M | 0.36% | Share |
| 8 | Squadron Capital Management LLC | 500,000 | $3.8M | 1.60% | Share |
| 9 | Ally Bridge Group (NY) LLC | 397,895 | $3.0M | 3.13% | Share |
| 10 | Velan Capital Investment Management LP | 352,000 | $2.7M | 1.54% | Share |
| 11 | Affinity Asset Advisors, LLC | 300,000 | $2.3M | 0.13% | Share |
| 12 | ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 278,064 | $2.0M | 0.00% | Share |
| 13 | UBS Group AG | 183,500 | $1.4M | 0.00% | Share |
| 14 | SummitTX Capital, L.P. | 175,948 | $1.3M | 0.04% | Share |
| 15 | BOOTHBAY FUND MANAGEMENT, LLC | 156,331 | $1.0M | 0.01% | Share |
| 16 | MARSHALL WACE, LLP | 135,152 | $1.0M | 0.00% | Share |
| 17 | ROYAL BANK OF CANADA | 188,042 | $1.0M | 0.00% | Share |
| 18 | BANK OF AMERICA CORP /DE/ | 253,221 | $1.0M | 0.00% | Share |
| 19 | ACADIAN ASSET MANAGEMENT LLC | 155,766 | $1.0M | 0.00% | Share |
| 20 | INGALLS & SNYDER LLC | 77,400 | $584K | 0.02% | Share |
| 21 | UBS Group AG | 36,499 | $275K | 0.00% | Share |
| 22 | TCI Wealth Advisors, Inc. | 11,000 | $83K | 0.00% | Share |
| 23 | GUARDIAN WEALTH ADVISORS, LLC / NC | 10,000 | $75K | 0.00% | Share |
| 24 | TD Waterhouse Canada Inc. | 9,600 | $71K | 0.00% | Share |
| 25 | 1832 Asset Management L.P. | 32,138 | $0 | 0.00% | Share |
| 26 | BANK OF AMERICA CORP /DE/ | 100 | $0 | 0.00% | Share |
| 27 | NATIONAL BANK OF CANADA /FI/ | 586 | $0 | 0.00% | Share |
| 28 | Aptus Capital Advisors, LLC | 10,000 | $0 | 0.00% | Share |
| 29 | BANK OF MONTREAL /CAN/ | 37,250 | $0 | 0.00% | Share |
| 30 | CIBC WORLD MARKET INC. | 58,050 | $0 | 0.00% | Share |
| 31 | Quadrature Capital Ltd | 43,186 | $0 | 0.00% | Share |
| 32 | XTX Topco Ltd | 16,180 | $0 | 0.00% | Share |
| 33 | RAYMOND JAMES FINANCIAL INC | 52,752 | $0 | 0.00% | Share |
| 34 | RAYMOND JAMES FINANCIAL INC | 220 | $0 | 0.00% | Share |
| 35 | JANE STREET GROUP, LLC | 11,260 | $0 | 0.00% | Share |
| 36 | Federation des caisses Desjardins du Quebec | 9,091 | $0 | 0.00% | Share |
| 37 | GOLDMAN SACHS GROUP INC | 58,058 | $0 | 0.00% | Share |
| 38 | JANE STREET GROUP, LLC | 18,362 | $0 | 0.00% | Share |
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 13,899 | $0 | 0.00% | Share |
| 40 | MARSHALL WACE, LLP | 22,981 | $0 | 0.00% | Share |
| 41 | UBS Group AG | 25 | $0 | 0.00% | Share |
| 42 | ROYAL BANK OF CANADA | 6,200 | $0 | 0.00% | Share |
| 43 | ROYAL BANK OF CANADA | 2,035 | $0 | 0.00% | Share |