Who Owns Structure Therapeutics Inc. (GPCR)?Hedge Fund & Institutional Holders

$53.78-0.80 (-1.47%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

—

QoQ Change in Holders

+4 / -8

Price History

$14.15$34.06$53.97$73.88$93.79Aug 24Jun 25Mar 26

GPCR — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+3.5M+$603.9B
WELLINGTON MANAGEMENT GROUP LLPIncreased+1.4M+$333.7B
Avoro Capital Advisors LLCIncreased+1.4M+$311.6B
JANUS HENDERSON GROUP PLCIncreased+641K+$226.4B
BVF INC/ILIncreased+275K+$152.3B
DRIEHAUS CAPITAL MANAGEMENT LLCIncreased+769K+$89.8B
PRINCIPAL FINANCIAL GROUP INCNew Position+1.3M+$89.3B
Capitolis Liquid Global Markets LLCNew Position+878K+$61.0B
ALLIANCEBERNSTEIN L.P.Increased+819K+$58.2B
DEUTSCHE BANK AG\New Position+841K+$58.0B
ORBIMED ADVISORS LLCIncreased+23K+$48.9B
PACIFIC HEIGHTS ASSET MANAGEMENT LLCNew Position+700K+$48.7B
Siren, L.L.C.Increased+52K+$46.3B
DEERFIELD MANAGEMENT COMPANY, L.P.Increased+395K+$43.0B
CITADEL ADVISORS LLCIncreased+329K+$40.6B

GPCR — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
RA CAPITAL MANAGEMENT, L.P.Closed Position-1.5M-$42.5B
MILLENNIUM MANAGEMENT LLCDecreased-1.1M-$25.7B
AMERIPRISE FINANCIAL INCDecreased-939K-$16.3B
Invesco Ltd.Decreased-441K-$12.2B
Point72 Asset Management, L.P.Closed Position-408K-$11.4B
Paradigm Biocapital Advisors LPClosed Position-373K-$10.4B
Nantahala Capital Management, LLCClosed Position-369K-$10.3B
SCHRODER INVESTMENT MANAGEMENT GROUPClosed Position-301K-$7.6B
TWO SIGMA ADVISERS, LPClosed Position-249K-$7.0B
SUSQUEHANNA INTERNATIONAL GROUP, LLPDecreased-205K-$6.0B
First Light Asset Management, LLCClosed Position-197K-$5.5B
Jefferies Financial Group Inc.Decreased-67K-$4.8B
Ikarian Capital, LLCDecreased-158K-$4.6B
SECTORAL ASSET MANAGEMENT INCDecreased-198K-$4.6B
Point72 Europe (London) LLPClosed Position-117K-$3.3B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC7,413,121$515.0B0.03%Share
2Avoro Capital Advisors LLC6,555,555$455.9B4.48%Share
3WELLINGTON MANAGEMENT GROUP LLP6,215,242$432.0B0.08%Share
4JANUS HENDERSON GROUP PLC4,945,939$343.0B0.15%Share
5BVF INC/IL3,479,022$242.0B8.15%Share
6DRIEHAUS CAPITAL MANAGEMENT LLC1,642,444$114.2B0.78%Share
7BAKER BROS. ADVISORS LP1,432,529$99.6B0.58%Share
8PRINCIPAL FINANCIAL GROUP INC1,284,210$89.3B0.05%Share
9Casdin Capital, LLC1,175,000$81.7B5.08%Share
10ORBIMED ADVISORS LLC1,161,803$80.8B1.65%Share
11Siren, L.L.C.1,078,698$75.0B2.24%Share
12TCG Crossover Management, LLC920,857$64.0B2.12%Share
13Capitolis Liquid Global Markets LLC878,300$61.0B0.36%Share
14FRANKLIN RESOURCES INC864,632$60.0B0.01%Share
15ALLIANCEBERNSTEIN L.P.848,851$59.0B0.02%Share
16DEUTSCHE BANK AG\841,162$58.0B0.02%Share
17DEERFIELD MANAGEMENT COMPANY, L.P.767,993$53.4B0.68%Share
18CITADEL ADVISORS LLC772,518$53.0B0.01%Share
19Rock Springs Capital Management LP748,236$52.0B2.67%Share
20PACIFIC HEIGHTS ASSET MANAGEMENT LLC700,000$48.7B1.82%Share
21Logos Global Management LP600,000$41.7B2.52%Share
22FMR LLC561,516$39.0B0.00%Share
23WELLINGTON MANAGEMENT GROUP LLP533,138$37.0B0.01%Share
24AMERICAN CENTURY COMPANIES INC506,959$35.0B0.02%Share
25HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND467,800$32.0B0.05%Share
26FARALLON CAPITAL MANAGEMENT LLC454,000$31.6B0.15%Share
27FMR LLC457,859$31.0B0.00%Share
28STEMPOINT CAPITAL LP351,073$24.4B4.19%Share
29HSG Holding Ltd254,750$23.4B1.24%Share
30EcoR1 Capital, LLC334,380$23.3B1.06%Share
31FMR LLC279,095$19.0B0.00%Share
32ArrowMark Colorado Holdings LLC271,213$18.9B0.42%Share
33Aberdeen Group plc264,869$18.4B0.03%Share
34Catalio Capital Management, LP252,901$17.6B3.11%Share
35Capricorn Fund Managers Ltd252,600$17.6B4.23%Share
36SUSQUEHANNA INTERNATIONAL GROUP, LLP236,100$16.0B0.00%Call
37BALYASNY ASSET MANAGEMENT L.P.216,199$15.0B0.02%Share
38UBS Group AG202,347$14.1B0.00%Share
39Sio Capital Management, LLC201,500$14.0B2.20%Share
40GOLDMAN SACHS GROUP INC213,684$14.0B0.00%Share
41DIADEMA PARTNERS LP191,700$13.3B2.30%Call
42HighVista Strategies LLC193,001$13.0B3.35%Share
43AMERIPRISE FINANCIAL INC200,645$13.0B0.00%Share
44GOLDMAN SACHS GROUP INC173,500$12.0B0.00%Call
45WELLINGTON MANAGEMENT GROUP LLP174,910$12.0B0.00%Share
46TD ASSET MANAGEMENT INC174,674$12.0B0.01%Share
47MILLENNIUM MANAGEMENT LLC152,560$10.0B0.00%Share
48Bellevue Group AG139,884$9.7B0.18%Share
49Eversept Partners, LP127,561$8.9B0.45%Share
50Woodline Partners LP123,902$8.0B0.03%Share

GPCR Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025195$3.8T+63
Q3 2025132$1.2T-12
Q2 2025144$710.7B-7
Q1 2025151$768.2B-9
Q4 2024160$1.4T+22
Q3 2024138$133.8T-8
Q2 2024146$106.7T+42
Q1 2024104$77.4T—

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As of Q4 2025, 50 institutional investors hold GPCR (Structure Therapeutics Inc.). The largest holder is FMR LLC with $515.0B in shares. This quarter, 4 institutions opened new positions and 8 closed their positions.

Frequently Asked Questions

How many hedge funds own GPCR?

As of Q4 2025, 50 institutional investors report holding GPCR (Structure Therapeutics Inc.) in their 13F filings.

Who is the largest institutional holder of GPCR?

The largest institutional holder of GPCR is FMR LLC with $515.0B in shares.

Is institutional ownership of GPCR increasing or decreasing?

This quarter, 4 institutions opened new positions in GPCR and 8 closed their positions.