Who Owns Karyopharm Therapeutics Inc. (KPTI)?Hedge Fund & Institutional Holders

$7.68-0.22 (-2.78%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$6.844654743134008e+132T

% of Float Held

1.1662285241111072e+251%

QoQ Change in Holders

+15 / -6

Price History

$3.54$6.37$9.19$12.02$14.85Aug 24Jun 25Mar 26

KPTI — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Opaleye Management Inc.New Position+930K+$6.8M
Affinity Asset Advisors, LLCNew Position+890K+$6.5M
Soleus Capital Management, L.P.New Position+440K+$3.2M
BRAIDWELL LPNew Position+303K+$2.2M
Exome Asset Management LLCNew Position+296K+$2.2M
DAVIDSON KEMPNER CAPITAL MANAGEMENT LPNew Position+310K+$2.0M
AMERIPRISE FINANCIAL INCNew Position+277K+$2.0M
Boxer Capital Management, LLCNew Position+253K+$1.9M
TWO SIGMA INVESTMENTS, LPNew Position+149K+$1.0M
BOOTHBAY FUND MANAGEMENT, LLCNew Position+145K+$1.0M
C WorldWide Group Holding A/SNew Position+100K+$736K
Context Capital Management, LLCNew Position+63K+$463K
DAFNA Capital Management LLCNew Position+51K+$375K
Trexquant Investment LPNew Position+42K+$307K
Persistent Asset Partners LtdNew Position+18K+$134K

KPTI — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
RENAISSANCE TECHNOLOGIES LLCDecreased-5K-$423.2M
MORGAN STANLEYDecreased-17K-$168.5M
GOLDMAN SACHS GROUP INCClosed Position-25K-$162.7M
XTX Topco LtdDecreased-2K-$94.2M
Tower Research Capital LLC (TRC)Closed Position-1K-$7.1M
CITIGROUP INCDecreased-512-$3.4M
OSAIC HOLDINGS, INC.Decreased-64-$2.4M
Rise Advisors, LLCClosed Position-131-$857K
T. Rowe Price Investment Management, Inc.Decreased-115K-$272K
GSA CAPITAL PARTNERS LLPClosed Position-14K-$92K
Advisory Services Network, LLCClosed Position-12-$78K
DANSKE BANK A/SClosed Position-3-$11K

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Opaleye Management Inc.930,000$6.8M0.90%Share
2Affinity Asset Advisors, LLC889,575$6.5M0.37%Share
3T. Rowe Price Investment Management, Inc.585,908$4.3M0.00%Share
4Ikarian Capital, LLC544,554$4.0M0.31%Share
5VANGUARD GROUP INC451,098$3.3M0.00%Share
6Soleus Capital Management, L.P.440,000$3.2M0.12%Share
7ADAGE CAPITAL PARTNERS GP, L.L.C.421,322$3.0M0.00%Share
8BRAIDWELL LP303,370$2.2M0.07%Share
9Exome Asset Management LLC295,541$2.2M1.04%Share
10SUSQUEHANNA INTERNATIONAL GROUP, LLP320,900$2.0M0.00%Call
11AMERIPRISE FINANCIAL INC276,881$2.0M0.00%Share
12SUSQUEHANNA INTERNATIONAL GROUP, LLP366,300$2.0M0.00%Put
13DAVIDSON KEMPNER CAPITAL MANAGEMENT LP310,020$2.0M0.03%Share
14Boxer Capital Management, LLC252,536$1.9M0.41%Share
15GROUP ONE TRADING LLC220,700$1.6M0.00%Call
16Catalio Capital Management, LP142,984$1.1M0.19%Share
17TWO SIGMA INVESTMENTS, LP148,793$1.0M0.00%Share
18SUSQUEHANNA INTERNATIONAL GROUP, LLP147,698$1.0M0.00%Share
19BOOTHBAY FUND MANAGEMENT, LLC144,628$1.0M0.01%Share
20GEODE CAPITAL MANAGEMENT, LLC146,832$1.0M0.00%Share
21BlackRock, Inc.162,584$1.0M0.00%Share
22Avidity Partners Management LP134,566$990K0.29%Share
23GROUP ONE TRADING LLC102,419$753K0.00%Share
24VANGUARD GROUP INC100,314$738K0.00%Share
25C WorldWide Group Holding A/S100,000$736K0.01%Share
26UBS Group AG86,674$637K0.00%Share
27GROUP ONE TRADING LLC78,500$577K0.00%Put
28Context Capital Management, LLC62,995$463K0.01%Share
29DAFNA Capital Management LLC51,000$375K0.09%Share
30ADAR1 Capital Management, LLC50,000$368K0.03%Share
31Trexquant Investment LP41,733$307K0.00%Share
32SILVERBACK ASSET MANAGEMENT LLC40,000$294K0.04%Share
33Persistent Asset Partners Ltd18,316$134K0.06%Share
34VANGUARD GROUP INC8,207$60K0.00%Share
35Leonteq Securities AG10,000$37K0.00%Share
36TD Waterhouse Canada Inc.3,203$23K0.00%Share
37UBS Group AG1,681$12K0.00%Share
38Corient Private Wealth LLC10,039$10K0.00%Share
39Aspect Partners, LLC391$2K0.00%Share
40Quent Capital, LLC235$1K0.00%Share
41NORTHERN TRUST CORP21$00.00%Share
42PRICE T ROWE ASSOCIATES INC /MD/10,886$00.00%Share
43TUDOR INVESTMENT CORP ET AL12,922$00.00%Share
44Baird Financial Group, Inc.27,993$00.00%Share
45Walleye Capital LLC95,672$00.00%Share
46BNP PARIBAS FINANCIAL MARKETS82$00.00%Share
47Bank of New York Mellon Corp10,341$00.00%Share
48Bank of New York Mellon Corp745$00.00%Share
49Bank of New York Mellon Corp1$00.00%Share
50Connor, Clark & Lunn Investment Management Ltd.57,212$00.00%Share

KPTI Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 202570$53.5M+29
Q3 202541$13.7B+1
Q2 202540$13.0B-7
Q1 202547$13.0B+46
Q4 20241$10.9M+0
Q2 20211$5.3B+0
Q1 20211$5.3B+0
Q4 20201$5.5B—

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As of Q4 2025, 50 institutional investors hold KPTI (Karyopharm Therapeutics Inc.). The largest holder is Opaleye Management Inc. with $6.8M in shares. This quarter, 15 institutions opened new positions and 6 closed their positions.

Frequently Asked Questions

How many hedge funds own KPTI?

As of Q4 2025, 50 institutional investors report holding KPTI (Karyopharm Therapeutics Inc.) in their 13F filings.

Who is the largest institutional holder of KPTI?

The largest institutional holder of KPTI is Opaleye Management Inc. with $6.8M in shares.

Is institutional ownership of KPTI increasing or decreasing?

This quarter, 15 institutions opened new positions in KPTI and 6 closed their positions.