| 1 | Atlas Venture Life Science Advisors, LLC | 1,137,149 | $9.1M | 1.05% | Share |
| 2 | NEA Management Company, LLC | 1,090,793 | $8.7M | 0.45% | Share |
| 3 | Lynx1 Capital Management LP | 677,915 | $5.4M | 1.10% | Share |
| 4 | Nantahala Capital Management, LLC | 600,000 | $4.8M | 0.16% | Share |
| 5 | VANGUARD GROUP INC | 446,050 | $3.6M | 0.00% | Share |
| 6 | TCG Crossover Management, LLC | 416,301 | $3.3M | 0.11% | Share |
| 7 | Siren, L.L.C. | 347,718 | $2.8M | 0.08% | Share |
| 8 | 72 Investment Holdings, LLC | 276,831 | $2.2M | 4.38% | Share |
| 9 | JANE STREET GROUP, LLC | 315,900 | $2.0M | 0.00% | Put |
| 10 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 312,200 | $2.0M | 0.00% | Put |
| 11 | BlackRock, Inc. | 255,137 | $2.0M | 0.00% | Share |
| 12 | CITADEL ADVISORS LLC | 279,000 | $2.0M | 0.00% | Put |
| 13 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 4,320 | $1.1M | 0.00% | Share |
| 14 | JANE STREET GROUP, LLC | 153,654 | $1.0M | 0.00% | Share |
| 15 | JANE STREET GROUP, LLC | 133,615 | $1.0M | 0.00% | Share |
| 16 | STATE STREET CORP | 146,221 | $1.0M | 0.00% | Share |
| 17 | BlackRock, Inc. | 164,167 | $1.0M | 0.00% | Share |
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,827 | $1.0M | 0.00% | Share |
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 141,993 | $1.0M | 0.00% | Share |
| 20 | MILLENNIUM MANAGEMENT LLC | 161,092 | $1.0M | 0.00% | Share |
| 21 | F/m Investments LLC | 65,548 | $525K | 0.02% | Share |
| 22 | EMERALD MUTUAL FUND ADVISERS TRUST | 65,548 | $525K | 0.03% | Share |
| 23 | VANGUARD GROUP INC | 41,660 | $333K | 0.00% | Share |
| 24 | AIHC Capital Management Ltd | 30,265 | $242K | 0.23% | Share |
| 25 | UBS Group AG | 18,020 | $144K | 0.00% | Share |
| 26 | GROUP ONE TRADING LLC | 5,000 | $40K | 0.00% | Put |
| 27 | GROUP ONE TRADING LLC | 4,300 | $34K | 0.00% | Call |
| 28 | GROUP ONE TRADING LLC | 4,000 | $32K | 0.00% | Share |
| 29 | VANGUARD GROUP INC | 1,929 | $15K | 0.00% | Share |
| 30 | UBS Group AG | 1,959 | $15K | 0.00% | Share |
| 31 | North Star Investment Management Corp. | 1,800 | $14K | 0.00% | Share |
| 32 | TD Waterhouse Canada Inc. | 800 | $6K | 0.00% | Share |
| 33 | DUNCKER STREETT & CO INC | 437 | $3K | 0.00% | Share |
| 34 | CWM, LLC | 288 | $2K | 0.00% | Share |
| 35 | ROTHSCHILD INVESTMENT LLC | 6 | $0 | 0.00% | Share |
| 36 | GOLDMAN SACHS GROUP INC | 51,950 | $0 | 0.00% | Share |
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 20,767 | $0 | 0.00% | Share |
| 38 | RHUMBLINE ADVISERS | 10,250 | $0 | 0.00% | Share |
| 39 | MARSHALL WACE, LLP | 8,099 | $0 | 0.00% | Share |
| 40 | MARSHALL WACE, LLP | 11,673 | $0 | 0.00% | Share |
| 41 | Sterling Capital Management LLC | 458 | $0 | 0.00% | Share |
| 42 | ROYAL BANK OF CANADA | 142 | $0 | 0.00% | Share |
| 43 | ROYAL BANK OF CANADA | 18 | $0 | 0.00% | Share |
| 44 | ROYAL BANK OF CANADA | 64 | $0 | 0.00% | Share |
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 408 | $0 | 0.00% | Share |
| 46 | AQR CAPITAL MANAGEMENT LLC | 7 | $0 | 0.00% | Share |
| 47 | AQR CAPITAL MANAGEMENT LLC | 14 | $0 | 0.00% | Share |
| 48 | AQR CAPITAL MANAGEMENT LLC | 40,621 | $0 | 0.00% | Share |
| 49 | AQR CAPITAL MANAGEMENT LLC | 5 | $0 | 0.00% | Share |
| 50 | TWO SIGMA INVESTMENTS, LP | 78,984 | $0 | 0.00% | Share |