| 1 | PERCEPTIVE ADVISORS LLC | 1,859,322 | $14.1M | 0.25% | Share |
| 2 | ACORN CAPITAL ADVISORS, LLC | 501,739 | $3.8M | 1.29% | Share |
| 3 | NEA Management Company, LLC | 464,398 | $3.5M | 0.18% | Share |
| 4 | Commodore Capital LP | 464,398 | $3.5M | 0.23% | Share |
| 5 | TCG Crossover Management, LLC | 464,398 | $3.3M | 0.11% | Share |
| 6 | Kalehua Capital Management LLC | 393,701 | $3.0M | 2.95% | Share |
| 7 | Spruce Street Capital LP | 393,701 | $3.0M | 0.98% | Share |
| 8 | ADAR1 Capital Management, LLC | 393,701 | $2.9M | 0.21% | Share |
| 9 | MILLENNIUM MANAGEMENT LLC | 324,445 | $2.0M | 0.00% | Share |
| 10 | Simplify Asset Management Inc. | 149,279 | $1.1M | 0.02% | Share |
| 11 | Propel Bio Management, LLC | 149,279 | $1.1M | 0.96% | Share |
| 12 | VANGUARD GROUP INC | 136,021 | $1.0M | 0.00% | Share |
| 13 | VANGUARD GROUP INC | 16,443 | $124K | 0.00% | Share |
| 14 | Scientech Research LLC | 10,108 | $76K | 0.05% | Share |
| 15 | UBS Group AG | 1,958 | $14K | 0.00% | Share |
| 16 | UBS Group AG | 1,337 | $10K | 0.00% | Share |
| 17 | VANGUARD GROUP INC | 1,325 | $10K | 0.00% | Share |
| 18 | American Capital Advisory, LLC | 200 | $1K | 0.00% | Share |
| 19 | JANE STREET GROUP, LLC | 10,282 | $0 | 0.00% | Share |
| 20 | JANE STREET GROUP, LLC | 4 | $0 | 0.00% | Share |
| 21 | JANE STREET GROUP, LLC | 2,900 | $0 | 0.00% | Share |
| 22 | ROTHSCHILD INVESTMENT LLC | 150 | $0 | 0.00% | Share |
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 25,507 | $0 | 0.00% | Share |
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 5,437 | $0 | 0.00% | Share |
| 25 | ROYAL BANK OF CANADA | 334 | $0 | 0.00% | Share |
| 26 | RENAISSANCE TECHNOLOGIES LLC | 75,147 | $0 | 0.00% | Share |
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 20,936 | $0 | 0.00% | Share |
| 28 | BANK OF AMERICA CORP /DE/ | 32,524 | $0 | 0.00% | Share |
| 29 | BANK OF AMERICA CORP /DE/ | 90 | $0 | 0.00% | Share |
| 30 | BANK OF AMERICA CORP /DE/ | 226 | $0 | 0.00% | Share |
| 31 | NORTHERN TRUST CORP | 10,461 | $0 | 0.00% | Share |
| 32 | JONES FINANCIAL COMPANIES LLLP | 33 | $0 | 0.00% | Share |
| 33 | BNP PARIBAS FINANCIAL MARKETS | 23 | $0 | 0.00% | Share |
| 34 | ACADIAN ASSET MANAGEMENT LLC | 37,482 | $0 | 0.00% | Share |
| 35 | MORGAN STANLEY | 470 | $0 | 0.00% | Share |
| 36 | JPMORGAN CHASE & CO | 12 | $0 | 0.00% | Share |
| 37 | STATE STREET CORP | 10,737 | $0 | 0.00% | Share |
| 38 | OSAIC HOLDINGS, INC. | 9,210 | $0 | 0.00% | Share |
| 39 | NewEdge Advisors, LLC | 50 | $0 | 0.00% | Share |
| 40 | UBS Group AG | 93 | $0 | 0.00% | Share |
| 41 | GROUP ONE TRADING LLC | 69 | $0 | 0.00% | Share |
| 42 | US BANCORP \DE\ | 81 | $0 | 0.00% | Share |
| 43 | SBI Securities Co., Ltd. | 12 | $0 | 0.00% | Share |
| 44 | BlackRock, Inc. | 37,243 | $0 | 0.00% | Share |
| 45 | BlackRock, Inc. | 25 | $0 | 0.00% | Share |
| 46 | McIlrath & Eck, LLC | 82 | $0 | 0.00% | Share |
| 47 | TWO SIGMA INVESTMENTS, LP | 10,746 | $0 | 0.00% | Share |
| 48 | Tower Research Capital LLC (TRC) | 379 | $0 | 0.00% | Share |
| 49 | Laird Norton Wetherby Trust Company, LLC | 11,730 | $0 | 0.00% | Share |
| 50 | Laird Norton Wetherby Trust Company, LLC | 10,088 | $0 | 0.00% | Share |