| 1 | Novo Holdings A/S | 3,686,622 | $64.8M | 5.03% | Share |
| 2 | FCPM III SERVICES B.V. | 3,226,400 | $56.7M | 7.43% | Share |
| 3 | T. Rowe Price Investment Management, Inc. | 2,799,180 | $49.2M | 0.05% | Share |
| 4 | GOLDMAN SACHS GROUP INC | 1,077,821 | $18.0M | 0.00% | Share |
| 5 | Nan Fung Group Holdings Ltd | 971,253 | $17.1M | 15.27% | Share |
| 6 | 5AM Venture Management, LLC | 950,011 | $16.7M | 5.25% | Share |
| 7 | Sanofi | 912,041 | $16.0M | 5.16% | Share |
| 8 | GOLDMAN SACHS GROUP INC | 859,347 | $15.0M | 0.00% | Share |
| 9 | VANGUARD GROUP INC | 760,318 | $13.4M | 0.00% | Share |
| 10 | Pivotal bioVenture Partners Investment Advisor LLC | 611,447 | $10.7M | 4.15% | Share |
| 11 | BlackRock, Inc. | 587,034 | $10.0M | 0.00% | Share |
| 12 | PERCEPTIVE ADVISORS LLC | 550,000 | $9.7M | 0.17% | Share |
| 13 | Velan Capital Investment Management LP | 492,893 | $8.7M | 5.02% | Share |
| 14 | Siren, L.L.C. | 450,000 | $7.9M | 0.24% | Share |
| 15 | BlackRock, Inc. | 421,049 | $7.0M | 0.00% | Share |
| 16 | Vestal Point Capital, LP | 385,000 | $6.8M | 0.23% | Share |
| 17 | BAKER BROS. ADVISORS LP | 364,705 | $6.4M | 0.04% | Share |
| 18 | Blue Owl Capital Holdings LP | 327,058 | $5.7M | 0.43% | Share |
| 19 | Jain Global LLC | 327,693 | $5.0M | 0.02% | Share |
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 336,130 | $5.0M | 0.00% | Share |
| 21 | STATE STREET CORP | 229,484 | $4.0M | 0.00% | Share |
| 22 | Board of Trustees of The Leland Stanford Junior University | 199,233 | $3.5M | 0.71% | Share |
| 23 | Freestone Grove Partners LP | 183,771 | $3.0M | 0.02% | Share |
| 24 | LAZARD ASSET MANAGEMENT LLC | 207,494 | $3.0M | 0.01% | Share |
| 25 | CITADEL ADVISORS LLC | 190,000 | $3.0M | 0.00% | Share |
| 26 | Tetragon Partners GP Ltd | 164,525 | $2.9M | 0.61% | Share |
| 27 | DAFNA Capital Management LLC | 143,764 | $2.5M | 0.59% | Share |
| 28 | BNP Paribas Asset Management Holding S.A. | 147,930 | $2.0M | 0.00% | Share |
| 29 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 138,427 | $2.0M | 0.00% | Share |
| 30 | NORTHERN TRUST CORP | 117,017 | $2.0M | 0.00% | Share |
| 31 | VANGUARD GROUP INC | 103,190 | $1.8M | 0.00% | Share |
| 32 | SEVEN GRAND MANAGERS, LLC | 100,000 | $1.8M | 0.13% | Share |
| 33 | STEMPOINT CAPITAL LP | 100,000 | $1.8M | 0.30% | Share |
| 34 | Burkehill Global Management, LP | 75,000 | $1.3M | 0.09% | Share |
| 35 | DIADEMA PARTNERS LP | 63,791 | $1.1M | 0.19% | Share |
| 36 | AMERIPRISE FINANCIAL INC | 66,872 | $1.0M | 0.00% | Share |
| 37 | ORBIMED ADVISORS LLC | 56,000 | $952K | 0.02% | Share |
| 38 | Velan Capital Investment Management LP | 29,412 | $516K | 0.30% | Share |
| 39 | Ghisallo Capital Management LLC | 20,000 | $351K | 0.02% | Share |
| 40 | UBS Group AG | 18,264 | $320K | 0.00% | Share |
| 41 | OXFORD ASSET MANAGEMENT LLP | 17,763 | $312K | 0.13% | Share |
| 42 | Persistent Asset Partners Ltd | 17,139 | $301K | 0.14% | Share |
| 43 | Lynx1 Capital Management LP | 13,477 | $236K | 0.05% | Share |
| 44 | Invesco Ltd. | 7,022 | $123K | 0.00% | Share |
| 45 | VANGUARD GROUP INC | 6,160 | $108K | 0.00% | Share |
| 46 | Persistent Asset Partners Ltd | 4,627 | $81K | 0.04% | Share |
| 47 | Invesco Ltd. | 3,362 | $59K | 0.00% | Share |
| 48 | STRS OHIO | 3,000 | $52K | 0.00% | Share |
| 49 | Invesco Ltd. | 2,586 | $45K | 0.00% | Share |
| 50 | SBI Securities Co., Ltd. | 607 | $10K | 0.00% | Share |