Who Owns Praxis Precision Medicines, Inc. (PRAX)?Hedge Fund & Institutional Holders

$292.43-10.95 (-3.61%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$9.370005882963778e+266T

% of Float Held

1.3750549446202777e+294%

QoQ Change in Holders

+15 / -1

Price History

$28.47$108.24$188.01$267.78$347.55Sep 24Jun 25Mar 26

PRAX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Orbis Allan Gray LtdNew Position+1.3M+$369.0M
RA CAPITAL MANAGEMENT, L.P.New Position+374K+$110.2M
Hood River Capital Management LLCNew Position+289K+$85.3M
Pictet Asset Management Holding SANew Position+241K+$71.1M
Affinity Asset Advisors, LLCNew Position+185K+$54.5M
Aberdeen Group plcNew Position+135K+$39.8M
ORBIMED ADVISORS LLCNew Position+95K+$27.9M
Bank of New York Mellon CorpNew Position+78K+$21.0M
CANADA PENSION PLAN INVESTMENT BOARDNew Position+70K+$20.0M
EVENTIDE ASSET MANAGEMENT, LLCNew Position+67K+$19.8M
RENAISSANCE TECHNOLOGIES LLCNew Position+66K+$19.0M
Ensign Peak Advisors, IncNew Position+64K+$18.0M
Boxer Capital Management, LLCNew Position+46K+$13.7M
KVP Capital Advisors, LPNew Position+43K+$12.6M
MOODY ALDRICH PARTNERS LLCNew Position+42K+$12.3M

PRAX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
ADAGE CAPITAL PARTNERS GP, L.L.C.Decreased-1.4M-$125.5B
Point72 Asset Management, L.P.Decreased-1.0M-$79.1B
Cormorant Asset Management, LPDecreased-50K-$52.7B
STATE STREET CORPDecreased-25K-$47.8B
Soleus Capital Management, L.P.Decreased-496K-$45.4B
Woodline Partners LPDecreased-312K-$22.1B
Assenagon Asset Management S.A.Decreased-992-$21.6B
Sofinnova Investments, Inc.Decreased-47K-$9.1B
5AM Venture Management, LLCClosed Position-170K-$9.0B
Alyeska Investment Group, L.P.Decreased-67K-$7.5B
Velan Capital Investment Management LPDecreased-32K-$7.0B
READYSTATE ASSET MANAGEMENT LPDecreased-72K-$5.8B
Exome Asset Management LLCDecreased-44K-$5.4B
UBS Group AGDecreased-8K-$5.1B
HighVista Strategies LLCDecreased-69K-$5.0B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1JANUS HENDERSON GROUP PLC3,181,758$937.0M0.42%Share
2PERCEPTIVE ADVISORS LLC1,995,986$588.3M10.49%Share
3VANGUARD GROUP INC1,281,691$377.8M0.01%Share
4Orbis Allan Gray Ltd1,252,573$369.0M1.55%Share
5FMR LLC1,181,123$348.0M0.02%Share
6BAKER BROS. ADVISORS LP1,126,488$332.0M1.94%Share
7BlackRock, Inc.1,056,070$311.0M0.01%Share
8ADAGE CAPITAL PARTNERS GP, L.L.C.965,313$284.0M0.43%Share
9Cormorant Asset Management, LP950,000$280.0M12.95%Share
10DRIEHAUS CAPITAL MANAGEMENT LLC933,061$275.0M1.87%Share
11DEERFIELD MANAGEMENT COMPANY, L.P.903,351$266.3M3.40%Share
12STATE STREET CORP882,215$260.0M0.01%Share
13MORGAN STANLEY832,379$245.0M0.01%Share
14PRICE T ROWE ASSOCIATES INC /MD/758,085$223.0M0.02%Share
15BlackRock, Inc.697,790$205.0M0.00%Share
16GOLDMAN SACHS GROUP INC643,371$189.0M0.02%Share
17Point72 Asset Management, L.P.500,000$147.0M0.16%Call
18Point72 Asset Management, L.P.492,346$145.0M0.16%Share
19GEODE CAPITAL MANAGEMENT, LLC486,872$143.0M0.01%Share
20BARCLAYS PLC469,106$138.0M0.03%Share
21BANK OF AMERICA CORP /DE/458,612$135.0M0.01%Share
22Assenagon Asset Management S.A.408,787$120.5M0.17%Share
23Logos Global Management LP375,000$110.5M6.68%Share
24RA CAPITAL MANAGEMENT, L.P.373,787$110.2M1.13%Share
25Soleus Capital Management, L.P.362,966$107.0M3.95%Share
26FRANKLIN RESOURCES INC354,998$104.0M0.03%Share
27Vivo Capital, LLC328,895$96.9M6.27%Share
28Hood River Capital Management LLC289,467$85.3M0.94%Share
29Pictet Asset Management Holding SA240,588$71.1M0.07%Share
30Caption Management, LLC200,000$58.9M0.40%Put
31CHARLES SCHWAB INVESTMENT MANAGEMENT INC198,301$58.0M0.01%Share
32Affinity Asset Advisors, LLC185,000$54.5M3.11%Share
33NORTHERN TRUST CORP174,199$51.0M0.01%Share
34683 Capital Management, LLC169,800$50.0M2.18%Put
35Qube Research & Technologies Ltd168,897$49.0M0.05%Share
36VANGUARD GROUP INC151,161$44.6M0.00%Share
37SUSQUEHANNA INTERNATIONAL GROUP, LLP150,700$44.0M0.01%Put
38Aberdeen Group plc134,992$39.8M0.06%Share
39Sofinnova Investments, Inc.125,722$37.1M1.60%Share
40Candriam S.C.A.110,590$32.0M0.16%Share
41Woodline Partners LP105,412$31.0M0.12%Share
42Velan Capital Investment Management LP100,781$29.7M17.23%Share
43DIADEMA PARTNERS LP100,600$29.6M5.11%Put
44ORBIMED ADVISORS LLC94,500$27.9M0.57%Share
45FMR LLC93,132$27.0M0.00%Share
46UBS Group AG88,932$26.2M0.00%Share
47BlackRock, Inc.90,237$26.0M0.00%Share
48FIRST TRUST ADVISORS LP88,704$26.0M0.02%Share
49Ikarian Capital, LLC86,581$25.5M1.99%Share
50WELLINGTON MANAGEMENT GROUP LLP88,034$25.0M0.00%Share

PRAX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025248$8.5B+121
Q3 2025127$1.2T+5
Q2 2025122$808.1B-30
Q1 2025152$840.4B-9
Q4 2024161$1.5T+46
Q3 2024115$613.4T+12
Q2 2024103$363.4T+8
Q1 202495$453.2T—

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As of Q4 2025, 50 institutional investors hold PRAX (Praxis Precision Medicines, Inc.). The largest holder is JANUS HENDERSON GROUP PLC with $937.0M in shares. This quarter, 15 institutions opened new positions and 1 closed their positions.

Frequently Asked Questions

How many hedge funds own PRAX?

As of Q4 2025, 50 institutional investors report holding PRAX (Praxis Precision Medicines, Inc.) in their 13F filings.

Who is the largest institutional holder of PRAX?

The largest institutional holder of PRAX is JANUS HENDERSON GROUP PLC with $937.0M in shares.

Is institutional ownership of PRAX increasing or decreasing?

This quarter, 15 institutions opened new positions in PRAX and 1 closed their positions.