| 1 | Portolan Capital Management, LLC | 4,525,553 | $28.8M | 1.54% | Share |
| 2 | AMERIPRISE FINANCIAL INC | 3,122,967 | $19.0M | 0.00% | Share |
| 3 | VANGUARD GROUP INC | 2,387,472 | $15.2M | 0.00% | Share |
| 4 | Blue Water Life Science Advisors, LP | 2,092,147 | $13.3M | 8.35% | Share |
| 5 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 2,046,449 | $13.0M | 0.04% | Share |
| 6 | BlackRock, Inc. | 1,940,458 | $12.0M | 0.00% | Share |
| 7 | AMERIPRISE FINANCIAL INC | 1,824,663 | $11.0M | 0.00% | Share |
| 8 | Invenomic Capital Management LP | 1,505,208 | $9.6M | 0.45% | Share |
| 9 | BlackRock, Inc. | 1,142,721 | $7.0M | 0.00% | Share |
| 10 | Trium Capital LLP | 817,451 | $5.2M | 4.03% | Share |
| 11 | STATE STREET CORP | 893,401 | $5.0M | 0.00% | Share |
| 12 | GEODE CAPITAL MANAGEMENT, LLC | 926,510 | $5.0M | 0.00% | Share |
| 13 | Williams Jones Wealth Management, LLC. | 638,939 | $4.0M | 0.05% | Share |
| 14 | Empire Financial Management Company, LLC | 617,830 | $3.9M | 0.85% | Share |
| 15 | EASTERLY INVESTMENT PARTNERS LLC | 616,681 | $3.9M | 0.24% | Share |
| 16 | Tikvah Management LLC | 571,619 | $3.6M | 0.97% | Share |
| 17 | First Eagle Investment Management, LLC | 531,427 | $3.4M | 0.01% | Share |
| 18 | Parkman Healthcare Partners LLC | 328,956 | $2.1M | 0.20% | Share |
| 19 | MILLENNIUM MANAGEMENT LLC | 402,631 | $2.0M | 0.00% | Share |
| 20 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 362,740 | $2.0M | 0.00% | Share |
| 21 | NORTHERN TRUST CORP | 327,716 | $2.0M | 0.00% | Share |
| 22 | DIMENSIONAL FUND ADVISORS LP | 346,441 | $2.0M | 0.00% | Share |
| 23 | MORGAN STANLEY | 448,734 | $2.0M | 0.00% | Share |
| 24 | UBS Group AG | 311,221 | $2.0M | 0.00% | Share |
| 25 | VANGUARD GROUP INC | 271,836 | $1.7M | 0.00% | Share |
| 26 | IRONWOOD INVESTMENT MANAGEMENT LLC | 172,330 | $1.1M | 0.46% | Share |
| 27 | GOLDMAN SACHS GROUP INC | 191,941 | $1.0M | 0.00% | Share |
| 28 | FMR LLC | 158,370 | $1.0M | 0.00% | Share |
| 29 | TWO SIGMA INVESTMENTS, LP | 258,858 | $1.0M | 0.00% | Share |
| 30 | MORGAN STANLEY | 213,839 | $1.0M | 0.00% | Share |
| 31 | ENVESTNET ASSET MANAGEMENT INC | 252,211 | $1.0M | 0.00% | Share |
| 32 | Russell Investments Group, Ltd. | 252,531 | $1.0M | 0.00% | Share |
| 33 | BNP PARIBAS FINANCIAL MARKETS | 168,430 | $1.0M | 0.00% | Share |
| 34 | TUDOR INVESTMENT CORP ET AL | 169,695 | $1.0M | 0.00% | Share |
| 35 | SCS Capital Management LLC | 120,035 | $763K | 0.01% | Share |
| 36 | Aberdeen Group plc | 104,039 | $661K | 0.00% | Share |
| 37 | Invesco Ltd. | 101,044 | $642K | 0.00% | Share |
| 38 | Clarius Group, LLC | 62,060 | $394K | 0.02% | Share |
| 39 | Schonfeld Strategic Advisors LLC | 61,722 | $392K | 0.00% | Share |
| 40 | Mount Lucas Management LP | 56,500 | $359K | 0.14% | Share |
| 41 | PEDDOCK CAPITAL ADVISORS, LLC | 52,105 | $331K | 0.07% | Share |
| 42 | PDT Partners, LLC | 47,668 | $303K | 0.02% | Share |
| 43 | PARAGON ASSOCIATES & PARAGON ASSOCIATES II JOINT VENTURE | 25,000 | $159K | 0.33% | Share |
| 44 | Virtu Financial LLC | 20,626 | $131K | 0.01% | Share |
| 45 | VANGUARD GROUP INC | 18,525 | $117K | 0.00% | Share |
| 46 | Allspring Global Investments Holdings, LLC | 15,453 | $99K | 0.00% | Share |
| 47 | DekaBank Deutsche Girozentrale | 4,566 | $80K | 0.00% | Share |
| 48 | Post Resch Tallon Group Inc. | 11,575 | $73K | 0.06% | Share |
| 49 | AXQ CAPITAL, LP | 11,009 | $70K | 0.02% | Share |
| 50 | Invesco Ltd. | 6,156 | $39K | 0.00% | Share |