| 1 | GATES FOUNDATION TRUST | 6,981,664 | $124.8M | 0.35% | Share |
| 2 | VANGUARD GROUP INC | 5,989,068 | $107.1M | 0.00% | Share |
| 3 | BlackRock, Inc. | 5,970,207 | $106.0M | 0.00% | Share |
| 4 | Sumitomo Mitsui Trust Group, Inc. | 4,714,767 | $84.3M | 0.05% | Share |
| 5 | Rubric Capital Management LP | 4,171,498 | $74.6M | 0.89% | Share |
| 6 | Amova Asset Management Americas, Inc. | 2,819,670 | $50.4M | 0.58% | Share |
| 7 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 2,285,830 | $40.9M | 0.01% | Share |
| 8 | Stephens Investment Management Group LLC | 2,250,098 | $40.2M | 0.52% | Share |
| 9 | BlackRock, Inc. | 2,131,540 | $38.0M | 0.00% | Share |
| 10 | LAZARD ASSET MANAGEMENT LLC | 2,134,968 | $38.0M | 0.06% | Share |
| 11 | STATE STREET CORP | 2,131,906 | $38.0M | 0.00% | Share |
| 12 | ARK Investment Management LLC | 2,111,829 | $37.8M | 0.25% | Share |
| 13 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,791,665 | $32.0M | 0.01% | Share |
| 14 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,593,775 | $28.0M | 0.01% | Share |
| 15 | PEAK6 LLC | 1,357,900 | $24.0M | 0.04% | Call |
| 16 | GEODE CAPITAL MANAGEMENT, LLC | 1,201,781 | $21.0M | 0.00% | Share |
| 17 | AMERICAN CENTURY COMPANIES INC | 1,107,677 | $19.0M | 0.01% | Share |
| 18 | UBS Group AG | 1,055,300 | $18.9M | 0.00% | Share |
| 19 | MILLENNIUM MANAGEMENT LLC | 978,172 | $17.0M | 0.01% | Share |
| 20 | DIMENSIONAL FUND ADVISORS LP | 940,228 | $16.0M | 0.00% | Share |
| 21 | MORGAN STANLEY | 573,509 | $10.0M | 0.00% | Share |
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 613,000 | $10.0M | 0.00% | Call |
| 23 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 515,903 | $9.0M | 0.00% | Share |
| 24 | BlackRock, Inc. | 518,397 | $9.0M | 0.00% | Share |
| 25 | TWO SIGMA ADVISERS, LP | 506,600 | $9.0M | 0.02% | Share |
| 26 | GOLDMAN SACHS GROUP INC | 498,541 | $8.0M | 0.00% | Share |
| 27 | NORTHERN TRUST CORP | 474,943 | $8.0M | 0.00% | Share |
| 28 | TWO SIGMA INVESTMENTS, LP | 436,792 | $7.0M | 0.01% | Share |
| 29 | TUDOR INVESTMENT CORP ET AL | 438,925 | $7.0M | 0.01% | Share |
| 30 | VANGUARD GROUP INC | 386,438 | $6.9M | 0.00% | Share |
| 31 | UBS Group AG | 378,173 | $6.8M | 0.00% | Share |
| 32 | BAILLIE GIFFORD & CO | 376,359 | $6.7M | 0.01% | Share |
| 33 | Parkman Healthcare Partners LLC | 298,939 | $5.3M | 0.51% | Share |
| 34 | Man Group plc | 296,713 | $5.0M | 0.01% | Share |
| 35 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 304,067 | $5.0M | 0.00% | Share |
| 36 | PRINCIPAL FINANCIAL GROUP INC | 265,034 | $4.7M | 0.00% | Share |
| 37 | JUPITER ASSET MANAGEMENT LTD | 223,892 | $4.0M | 0.03% | Share |
| 38 | Allianz Asset Management GmbH | 248,053 | $4.0M | 0.00% | Share |
| 39 | BlackRock, Inc. | 243,534 | $4.0M | 0.00% | Share |
| 40 | FRED ALGER MANAGEMENT, LLC | 269,825 | $4.0M | 0.02% | Share |
| 41 | BlackRock, Inc. | 245,379 | $4.0M | 0.00% | Share |
| 42 | Connor, Clark & Lunn Investment Management Ltd. | 273,254 | $4.0M | 0.01% | Share |
| 43 | PERCEPTIVE ADVISORS LLC | 202,400 | $3.6M | 0.06% | Share |
| 44 | BAILLIE GIFFORD & CO | 200,782 | $3.6M | 0.00% | Share |
| 45 | Allspring Global Investments Holdings, LLC | 185,007 | $3.3M | 0.01% | Share |
| 46 | BAILLIE GIFFORD & CO | 176,028 | $3.1M | 0.00% | Share |
| 47 | GEODE CAPITAL MANAGEMENT, LLC | 183,007 | $3.0M | 0.00% | Share |
| 48 | BlackRock, Inc. | 196,644 | $3.0M | 0.00% | Share |
| 49 | ALGERT GLOBAL LLC | 211,427 | $3.0M | 0.05% | Share |
| 50 | GOLDMAN SACHS GROUP INC | 170,927 | $3.0M | 0.00% | Share |