| 1 | TCG Crossover Management, LLC | 3,033,560 | $18.4M | 0.61% | Share |
| 2 | Siren, L.L.C. | 2,911,438 | $17.7M | 0.53% | Share |
| 3 | Redmile Group, LLC | 2,164,777 | $13.2M | 0.97% | Share |
| 4 | Nantahala Capital Management, LLC | 1,542,427 | $9.4M | 0.31% | Share |
| 5 | Vivo Capital, LLC | 1,105,454 | $6.7M | 0.43% | Share |
| 6 | Nextech Invest, Ltd. | 952,400 | $5.8M | 0.56% | Share |
| 7 | GREAT POINT PARTNERS LLC | 808,032 | $4.9M | 1.59% | Share |
| 8 | MILLENNIUM MANAGEMENT LLC | 659,592 | $4.0M | 0.00% | Share |
| 9 | 5AM Venture Management, LLC | 476,200 | $2.9M | 0.91% | Share |
| 10 | Tetragon Partners GP Ltd | 365,369 | $2.2M | 0.47% | Share |
| 11 | Ikarian Capital, LLC | 865,784 | $1.7M | 0.14% | Share |
| 12 | SG Americas Securities, LLC | 256,340 | $1.6M | 0.00% | Share |
| 13 | Ishara Investments LP | 240,000 | $1.5M | 1.67% | Share |
| 14 | UBS Group AG | 199,310 | $1.2M | 0.00% | Share |
| 15 | Lombard Odier Asset Management (USA) Corp | 255,901 | $1.2M | 0.11% | Share |
| 16 | M28 Capital Management LP | 185,100 | $1.1M | 0.82% | Share |
| 17 | HSBC HOLDINGS PLC | 172,834 | $1.1M | 0.00% | Share |
| 18 | MORGAN STANLEY | 294,867 | $1.0M | 0.00% | Share |
| 19 | BOOTHBAY FUND MANAGEMENT, LLC | 209,088 | $1.0M | 0.01% | Share |
| 20 | Opaleye Management Inc. | 78,926 | $479K | 0.06% | Share |
| 21 | ADAR1 Capital Management, LLC | 23,643 | $143K | 0.01% | Share |
| 22 | China Universal Asset Management Co., Ltd. | 13,653 | $83K | 0.01% | Share |
| 23 | GAMMA Investing LLC | 10,112 | $61K | 0.00% | Share |
| 24 | UBS Group AG | 6,164 | $37K | 0.00% | Share |
| 25 | Mirae Asset Global Investments Co., Ltd. | 2,282 | $13K | 0.00% | Share |
| 26 | UBS Group AG | 1,200 | $7K | 0.00% | Share |
| 27 | UBS Group AG | 839 | $5K | 0.00% | Share |
| 28 | GF FUND MANAGEMENT CO. LTD. | 922 | $5K | 0.00% | Share |
| 29 | MARSHALL WACE, LLP | 152,771 | $0 | 0.00% | Share |
| 30 | ROYAL BANK OF CANADA | 16 | $0 | 0.00% | Share |
| 31 | TWO SIGMA INVESTMENTS, LP | 39,344 | $0 | 0.00% | Share |
| 32 | CITADEL ADVISORS LLC | 140,870 | $0 | 0.00% | Share |
| 33 | CITADEL ADVISORS LLC | 103,191 | $0 | 0.00% | Share |
| 34 | CITADEL ADVISORS LLC | 14,800 | $0 | 0.00% | Put |
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 16,866 | $0 | 0.00% | Share |
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 25,000 | $0 | 0.00% | Put |
| 37 | BANK OF AMERICA CORP /DE/ | 673 | $0 | 0.00% | Share |
| 38 | BANK OF AMERICA CORP /DE/ | 550 | $0 | 0.00% | Share |
| 39 | BANK OF AMERICA CORP /DE/ | 1,743 | $0 | 0.00% | Share |
| 40 | Parallel Advisors, LLC | 1,300 | $0 | 0.00% | Share |
| 41 | Global Retirement Partners, LLC | 1,000 | $0 | 0.00% | Share |
| 42 | MORGAN STANLEY | 377 | $0 | 0.00% | Share |
| 43 | MORGAN STANLEY | 3,865 | $0 | 0.00% | Share |
| 44 | BlackRock, Inc. | 42,748 | $0 | 0.00% | Share |
| 45 | BlackRock, Inc. | 30,405 | $0 | 0.00% | Share |
| 46 | Quadrature Capital Ltd | 54,380 | $0 | 0.00% | Share |
| 47 | OSAIC HOLDINGS, INC. | 3 | $0 | 0.00% | Share |
| 48 | SIMPLEX TRADING, LLC | 3,991 | $0 | 0.00% | Share |
| 49 | SIMPLEX TRADING, LLC | 100 | $0 | 0.00% | Call |
| 50 | SIMPLEX TRADING, LLC | 5,900 | $0 | 0.00% | Put |