| 1 | BlackRock, Inc. | 8,542,251 | $104.9T | 2.20% | — |
| 2 | Kynam Capital Management, LP | 8,520,000 | $104.7T | 8.79% | — |
| 3 | Eversept Partners, LP | 4,212,270 | $51.7T | 5.26% | — |
| 4 | Point72 Asset Management, L.P. | 4,008,700 | $49.2T | 100.00% | — |
| 5 | GOLDMAN SACHS GROUP INC | 3,921,541 | $48.2T | 7.80% | — |
| 6 | Octagon Capital Advisors LP | 27,330,800 | $48.1T | 9.31% | — |
| 7 | CITADEL ADVISORS LLC | 2,914,882 | $35.8T | 6.79% | — |
| 8 | BANK OF AMERICA CORP /DE/ | 2,870,999 | $35.3T | 2.85% | — |
| 9 | MORGAN STANLEY | 2,281,916 | $28.0T | 2.00% | — |
| 10 | Sofinnova Investments, Inc. | 2,275,223 | $28.0T | 1.83% | — |
| 11 | FRANKLIN RESOURCES INC | 2,061,405 | $25.3T | 7.29% | — |
| 12 | Assenagon Asset Management S.A. | 2,039,987 | $25.1T | 41.80% | — |
| 13 | GEODE CAPITAL MANAGEMENT, LLC | 2,022,985 | $24.9T | 1.95% | — |
| 14 | Woodline Partners LP | 1,891,803 | $23.2T | 100.00% | — |
| 15 | BALYASNY ASSET MANAGEMENT L.P. | 1,817,009 | $22.3T | 36.91% | — |
| 16 | Catalio Capital Management, LP | 1,733,701 | $21.3T | 5.18% | — |
| 17 | UBS Group AG | 1,715,778 | $21.1T | 3.87% | — |
| 18 | STEMPOINT CAPITAL LP | 1,598,594 | $19.6T | 6.26% | — |
| 19 | SILVERARC CAPITAL MANAGEMENT, LLC | 1,309,224 | $16.1T | 3.29% | — |
| 20 | THORNBURG INVESTMENT MANAGEMENT INC | 130,746 | $16.1T | 22.45% | — |
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 1,178,062 | $14.5T | 100.00% | — |
| 22 | Saturn V Capital Management LP | 1,041,280 | $12.8T | 6.46% | — |
| 23 | Aisling Capital Management LP | 1,025,000 | $12.6T | 4.36% | — |
| 24 | PFM Health Sciences, LP | 926,424 | $11.4T | 0.83% | — |
| 25 | Avidity Partners Management LP | 925,000 | $11.4T | 2.17% | — |
| 26 | Qube Research & Technologies Ltd | 834,849 | $10.3T | 11.90% | — |
| 27 | Soleus Capital Management, L.P. | 816,610 | $10.0T | 0.72% | — |
| 28 | D. E. Shaw & Co., Inc. | 787,587 | $9.7T | 8.61% | — |
| 29 | TWO SIGMA INVESTMENTS, LP | 780,009 | $9.6T | 20.48% | — |
| 30 | NORTHERN TRUST CORP | 778,758 | $9.6T | 1.42% | — |
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 689,693 | $8.5T | 1.59% | — |
| 32 | Ensign Peak Advisors, Inc | 689,064 | $8.5T | 16.19% | — |
| 33 | RENAISSANCE TECHNOLOGIES LLC | 681,427 | $8.4T | 12.67% | — |
| 34 | Casdin Capital, LLC | 635,000 | $7.8T | 0.64% | — |
| 35 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 631,640 | $7.8T | 14.37% | — |
| 36 | Nantahala Capital Management, LLC | 554,503 | $6.8T | 0.27% | — |
| 37 | Granahan Investment Management, LLC | 549,942 | $6.8T | 0.34% | — |
| 38 | TWO SIGMA ADVISERS, LP | 503,152 | $6.2T | 13.92% | — |
| 39 | DIMENSIONAL FUND ADVISORS LP | 465,882 | $5.7T | 1.42% | — |
| 40 | Candriam S.C.A. | 450,435 | $5.5T | 34.66% | — |
| 41 | Palo Alto Investors LP | 444,367 | $5.5T | 1.04% | — |
| 42 | MILLENNIUM MANAGEMENT LLC | 428,652 | $5.3T | 2.80% | — |
| 43 | Trexquant Investment LP | 386,263 | $4.7T | 55.20% | — |
| 44 | AQR CAPITAL MANAGEMENT LLC | 377,444 | $4.6T | 4.78% | — |
| 45 | Exome Asset Management LLC | 337,198 | $4.1T | 3.68% | — |
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 329,906 | $4.1T | 0.69% | — |
| 47 | Walleye Capital LLC | 327,134 | $4.0T | 18.14% | — |
| 48 | ExodusPoint Capital Management, LP | 314,407 | $3.9T | 38.19% | — |
| 49 | TWINBEECH CAPITAL LP | 255,832 | $3.1T | 57.05% | — |
| 50 | Hudson Bay Capital Management LP | 250,000 | $3.1T | 9.47% | — |