Who Owns Spyre Therapeutics, Inc. (SYRE)?Hedge Fund & Institutional Holders

$40.22-0.19 (-0.47%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+3 / -10

Price History

$11.80$19.89$27.99$36.08$44.18Sep 24Jun 25Mar 26

SYRE — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+2.6M+$379.8B
PERCEPTIVE ADVISORS LLCIncreased+1.8M+$79.9B
VR Adviser, LLCIncreased+1.0M+$75.7B
DRIEHAUS CAPITAL MANAGEMENT LLCIncreased+822K+$59.9B
JANUS HENDERSON GROUP PLCIncreased+1.8M+$58.8B
Commodore Capital LPIncreased+400K+$44.9B
TCG Crossover Management, LLCIncreased+800K+$43.8B
Affinity Asset Advisors, LLCIncreased+13K+$23.1B
FRANKLIN RESOURCES INCIncreased+314K+$22.7B
Point72 Asset Management, L.P.New Position+662K+$21.0B
EMERALD ADVISERS, LLCNew Position+636K+$20.8B
Siren, L.L.C.Increased+450K+$20.6B
UBS Group AGIncreased+295K+$15.8B
EMERALD MUTUAL FUND ADVISERS TRUSTNew Position+412K+$13.5B
DEERFIELD MANAGEMENT COMPANY, L.P.Increased+97K+$13.0B

SYRE — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Jefferies Financial Group Inc.Closed Position-1.4M-$23.3B
MILLENNIUM MANAGEMENT LLCDecreased-332K-$4.8B
JPMORGAN CHASE & CODecreased-213K-$4.6B
VOLORIDGE INVESTMENT MANAGEMENT, LLCClosed Position-264K-$4.4B
JANE STREET GROUP, LLCClosed Position-96K-$1.6B
VICTORY CAPITAL MANAGEMENT INCDecreased-180K-$1.5B
Schonfeld Strategic Advisors LLCClosed Position-81K-$1.4B
Verition Fund Management LLCClosed Position-48K-$812.8M
SCHRODER INVESTMENT MANAGEMENT GROUPDecreased-46K-$762.6M
STATE OF WISCONSIN INVESTMENT BOARDDecreased-6K-$562.2M
DLD Asset Management, LPClosed Position-30K-$502.8M
Jump Financial, LLCClosed Position-27K-$454.2M
Squarepoint Ops LLCClosed Position-20K-$339.1M
Quadrature Capital LtdClosed Position-19K-$324.8M
DRW Securities, LLCClosed Position-11K-$190.2M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC8,365,485$274.0B0.01%Share
2Fairmount Funds Management LLC4,018,101$131.6B10.02%Share
3VR Adviser, LLC3,685,448$120.7B5.96%Share
4FMR LLC3,165,797$103.0B0.01%Share
5PERCEPTIVE ADVISORS LLC3,069,225$100.5B1.79%Share
6DRIEHAUS CAPITAL MANAGEMENT LLC2,882,420$94.4B0.64%Share
7Commodore Capital LP2,388,245$78.2B5.21%Share
8TCG Crossover Management, LLC1,900,582$62.3B2.06%Share
9TANG CAPITAL MANAGEMENT LLC1,892,200$62.0B3.06%Share
10JANUS HENDERSON GROUP PLC1,807,609$59.0B0.03%Share
11Affinity Asset Advisors, LLC1,432,591$46.9B2.67%Share
12FRANKLIN RESOURCES INC1,109,227$36.0B0.01%Share
13BAKER BROS. ADVISORS LP1,000,000$32.8B0.19%Share
14WELLINGTON MANAGEMENT GROUP LLP976,583$31.0B0.01%Share
15Siren, L.L.C.818,598$26.8B0.80%Share
16Polar Capital Holdings Plc740,326$24.0B0.09%Share
17DEERFIELD MANAGEMENT COMPANY, L.P.710,626$23.3B0.30%Share
18UBS Group AG676,123$22.1B0.00%Share
19Point72 Asset Management, L.P.662,351$21.0B0.02%Share
20EMERALD ADVISERS, LLC636,109$20.8B0.64%Share
21CHARLES SCHWAB INVESTMENT MANAGEMENT INC574,622$18.0B0.00%Share
22Blackstone Inc.500,998$16.4B0.06%Share
23NORTHERN TRUST CORP515,556$16.0B0.00%Share
24EMERALD MUTUAL FUND ADVISERS TRUST412,371$13.5B0.66%Share
25Caption Management, LLC399,900$13.1B0.09%Call
26Candriam S.C.A.425,534$13.0B0.06%Share
27WELLINGTON MANAGEMENT GROUP LLP383,209$12.0B0.00%Share
28BANK OF AMERICA CORP /DE/379,165$12.0B0.00%Share
29Woodline Partners LP265,892$8.0B0.03%Share
30SILVERARC CAPITAL MANAGEMENT, LLC187,737$6.2B0.85%Share
31HighVista Strategies LLC188,206$6.0B1.55%Share
32Capital World Investors200,172$6.0B0.00%Share
33Universal- Beteiligungs- und Servicegesellschaft mbH171,211$5.6B0.01%Share
34BARCLAYS PLC182,498$5.0B0.00%Share
35GOLDMAN SACHS GROUP INC162,429$5.0B0.00%Share
36Patient Square Capital LP150,000$4.9B1.05%Share
37MANUFACTURERS LIFE INSURANCE COMPANY, THE129,013$4.0B0.00%Share
38VICTORY CAPITAL MANAGEMENT INC146,079$4.0B0.00%Share
39Nuveen, LLC144,863$4.0B0.00%Share
40TD ASSET MANAGEMENT INC149,822$4.0B0.00%Share
41WELLINGTON MANAGEMENT GROUP LLP133,589$4.0B0.00%Share
42Invesco Ltd.120,478$3.9B0.00%Share
43F/m Investments LLC103,718$3.4B0.13%Share
44B Group, Inc.100,000$3.3B2.42%Share
45GOLDMAN SACHS GROUP INC112,636$3.0B0.00%Share
46Swiss National Bank96,500$3.0B0.00%Share
47MERCER GLOBAL ADVISORS INC /ADV106,316$3.0B0.00%Share
48FMR LLC107,537$3.0B0.00%Share
49CITIGROUP INC98,499$3.0B0.00%Share
50DIMENSIONAL FUND ADVISORS LP77,290$2.0B0.00%Share

SYRE Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025154$1.6T+37
Q3 2025117$641.8B+16
Q2 2025101$573.5B-29
Q1 2025130$711.0B-1
Q4 2024131$868.1B+27
Q3 2024104$102.4T+6
Q2 202498$107.0T+8
Q1 202490$66.9T—

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As of Q4 2025, 50 institutional investors hold SYRE (Spyre Therapeutics, Inc.). The largest holder is FMR LLC with $274.0B in shares. This quarter, 3 institutions opened new positions and 10 closed their positions.

Frequently Asked Questions

How many hedge funds own SYRE?

As of Q4 2025, 50 institutional investors report holding SYRE (Spyre Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of SYRE?

The largest institutional holder of SYRE is FMR LLC with $274.0B in shares.

Is institutional ownership of SYRE increasing or decreasing?

This quarter, 3 institutions opened new positions in SYRE and 10 closed their positions.