| 1 | Ikarian Capital, LLC | 967,600 | $11.8M | 0.92% | Share |
| 2 | MORGAN STANLEY | 592,316 | $7.0M | 0.00% | Share |
| 3 | PERCEPTIVE ADVISORS LLC | 439,142 | $5.4M | 0.10% | Share |
| 4 | Siren, L.L.C. | 427,141 | $5.2M | 0.16% | Share |
| 5 | Point72 Asset Management, L.P. | 423,415 | $5.0M | 0.01% | Share |
| 6 | RTW INVESTMENTS, LP | 378,346 | $4.6M | 0.05% | Share |
| 7 | BVF INC/IL | 339,549 | $4.1M | 0.14% | Share |
| 8 | BOOTHBAY FUND MANAGEMENT, LLC | 352,206 | $4.0M | 0.06% | Share |
| 9 | MILLENNIUM MANAGEMENT LLC | 302,473 | $3.0M | 0.00% | Share |
| 10 | MARSHALL WACE, LLP | 284,201 | $3.0M | 0.00% | Share |
| 11 | DIADEMA PARTNERS LP | 243,170 | $3.0M | 0.51% | Share |
| 12 | VANGUARD GROUP INC | 218,935 | $2.7M | 0.00% | Share |
| 13 | Vivo Capital, LLC | 208,333 | $2.5M | 0.16% | Share |
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 190,111 | $2.3M | 0.45% | Share |
| 15 | Integral Health Asset Management, LLC | 167,000 | $2.0M | 0.10% | Share |
| 16 | JANUS HENDERSON GROUP PLC | 166,666 | $2.0M | 0.00% | Share |
| 17 | Velan Capital Investment Management LP | 83,333 | $1.0M | 0.59% | Share |
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 83,333 | $1.0M | 0.00% | Share |
| 19 | Woodline Partners LP | 143,481 | $1.0M | 0.00% | Share |
| 20 | CITADEL ADVISORS LLC | 107,904 | $1.0M | 0.00% | Share |
| 21 | RENAISSANCE TECHNOLOGIES LLC | 125,579 | $1.0M | 0.00% | Share |
| 22 | FMR LLC | 141,100 | $1.0M | 0.00% | Share |
| 23 | Persistent Asset Partners Ltd | 65,272 | $795K | 0.36% | Share |
| 24 | ADAR1 Capital Management, LLC | 63,673 | $776K | 0.06% | Share |
| 25 | Vestal Point Capital, LP | 53,439 | $651K | 0.02% | Share |
| 26 | Artia Global Partners LP | 42,080 | $512K | 0.07% | Share |
| 27 | VANGUARD GROUP INC | 33,430 | $407K | 0.00% | Share |
| 28 | Corient Private Wealth LLC | 12,388 | $151K | 0.00% | Share |
| 29 | Stonepine Capital Management, LLC | 11,884 | $144K | 0.11% | Share |
| 30 | LETKO, BROSSEAU & ASSOCIATES INC | 10,650 | $129K | 0.00% | Share |
| 31 | VANGUARD GROUP INC | 3,299 | $40K | 0.00% | Share |
| 32 | UBS Group AG | 673 | $8K | 0.00% | Share |
| 33 | BANK OF AMERICA CORP /DE/ | 3,533 | $0 | 0.00% | Share |
| 34 | UBS Group AG | 1 | $0 | 0.00% | Share |
| 35 | MARSHALL WACE, LLP | 3,391 | $0 | 0.00% | Share |
| 36 | MARSHALL WACE, LLP | 10,561 | $0 | 0.00% | Share |
| 37 | TWO SIGMA ADVISERS, LP | 13,178 | $0 | 0.00% | Share |
| 38 | BANK OF AMERICA CORP /DE/ | 47 | $0 | 0.00% | Share |
| 39 | BANK OF AMERICA CORP /DE/ | 200 | $0 | 0.00% | Share |
| 40 | UBS Group AG | 2 | $0 | 0.00% | Share |
| 41 | JPMORGAN CHASE & CO | 902 | $0 | 0.00% | Share |
| 42 | CITADEL ADVISORS LLC | 21,624 | $0 | 0.00% | Share |
| 43 | Tower Research Capital LLC (TRC) | 199 | $0 | 0.00% | Share |
| 44 | TWO SIGMA INVESTMENTS, LP | 33,470 | $0 | 0.00% | Share |
| 45 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 44,900 | $0 | 0.00% | Share |
| 46 | JONES FINANCIAL COMPANIES LLLP | 1 | $0 | 0.00% | Share |
| 47 | BNP PARIBAS FINANCIAL MARKETS | 15,296 | $0 | 0.00% | Share |
| 48 | MORGAN STANLEY | 4,060 | $0 | 0.00% | Share |
| 49 | BlackRock, Inc. | 16,714 | $0 | 0.00% | Share |
| 50 | GEODE CAPITAL MANAGEMENT, LLC | 15,866 | $0 | 0.00% | Share |