BAKER BROS. ADVISORS LP Q1 2020 Filing

Filed May 15, 2020

Portfolio Value

$16.2T

Holdings

110

Report Date

Q1 2020

Filing Type

13F-HR

All Holdings (110 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
50,060,240$5.8T35.57%
2
INCYIncyte Corporation
31,978,785$2.3T14.42%
3
ACADACADIA Pharmaceuticals Inc.
41,904,586$1.8T10.90%
4
ONCBeiGene, Ltd.
11,777,285$1.4T8.93%
5
ALXNAlexion Pharmaceuticals, Inc.
8,760,794$786.6B4.84%
6
BMRNBioMarin Pharmaceutical Inc.
7,589,294$641.3B3.95%
7
KODKodiak Sciences Inc.
11,574,538$552.1B3.40%
8
ASNDAscendis Pharma A/S
3,390,270$381.8B2.35%
9
1K0IGM Biosciences, Inc.
3,144,000$176.5B1.09%
10
AMRNAmarin Corporation plc
34,496,685$138.0B0.85%
11
ARGXargenx SE
1,019,557$134.3B0.83%
12
NVTA1EURInvitae Corporation
9,100,615$124.4B0.77%
13
Principia Biopharma Inc.
1,955,413$116.1B0.72%
14
MRTXEURMirati Therapeutics, Inc.
1,409,784$108.4B0.67%
15
NBIXNeurocrine Biosciences, Inc.
1,240,243$107.3B0.66%
16
EXASExact Sciences Corporation
1,846,139$107.1B0.66%
17
Ra Pharmaceuticals, Inc.
2,093,839$100.5B0.62%
18
MDGLMadrigal Pharmaceuticals, Inc.
1,499,212$100.1B0.62%
19
MyoKardia, Inc.
1,774,234$83.2B0.51%
20
HRTXHeron Therapeutics, Inc.
6,018,104$70.7B0.44%
21
CERSCerus Corporation
13,713,195$63.8B0.39%
22
Zymeworks Inc.
1,708,472$60.6B0.37%
23
1T7Tricida, Inc.
2,666,015$58.7B0.36%
24
BCELAtreca, Inc.
3,532,760$58.5B0.36%
25
DBV Technologies S.A.
14,614,264$57.3B0.35%
26
AXSMAxsome Therapeutics, Inc.
889,757$52.3B0.32%
27
IM8NInsmed Incorporated
3,025,384$48.5B0.30%
28
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$43.3B0.27%
29
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$41.2B0.25%
30
KRYSKrystal Biotech, Inc.
946,471$40.9B0.25%
31
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$39.3B0.24%
32
Neoleukin Therapeutics, Inc.
3,397,740$38.7B0.24%
33
CCXIEURChemoCentryx, Inc.
859,015$34.5B0.21%
34
ALLKGUSDAllakos Inc.
735,469$32.7B0.20%
35
GW Pharmaceuticals plc
370,845$32.5B0.20%
36
AUPHAurinia Pharmaceuticals Inc.
1,701,929$24.7B0.15%
37
MRUSMerus N.V.
2,037,469$24.7B0.15%
38
APLSApellis Pharmaceuticals, Inc.
896,551$24.0B0.15%
39
ASMBAssembly Biosciences, Inc.
1,541,618$22.9B0.14%
40
BCRXBioCryst Pharmaceuticals, Inc.
10,946,166$21.9B0.13%
41
Frequency Therapeutics, Inc.
1,180,162$21.0B0.13%
42
ADPTAdaptive Biotechnologies Corporation
743,734$20.7B0.13%
43
ALKSAlkermes plc
1,244,744$17.9B0.11%
44
QUREuniQure N.V.
357,083$16.9B0.10%
45
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$15.6B0.10%
46
XNCRXencor, Inc.
428,120$12.8B0.08%
47
URGNUroGen Pharma Ltd.
672,912$12.0B0.07%
48
PTGXProtagonist Therapeutics, Inc.
1,679,164$11.9B0.07%
49
ADAPYAdaptimmune Therapeutics plc
3,690,307$10.0B0.06%
50
Aimmune Therapeutics, Inc.
673,908$9.7B0.06%
51
Urovant Sciences Ltd.
1,000,000$9.2B0.06%
52
MIRMMirum Pharmaceuticals, Inc.
583,333$8.2B0.05%
53
RETAEURReata Pharmaceuticals, Inc.
55,983$8.1B0.05%
54
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$8.0B0.05%
55
IFRXInflarx N.V.
1,778,415$6.8B0.04%
56
ALECAlector, Inc.
280,000$6.8B0.04%
57
GBYSangamo Therapeutics, Inc.
999,823$6.4B0.04%
58
BioDelivery Sciences International, Inc.
1,638,334$6.2B0.04%
59
FLGTFulgent Genetics, Inc.
569,444$6.1B0.04%
60
Idera Pharmaceuticals, Inc.
4,608,786$6.1B0.04%
61
BDQMAlbireo Pharma, Inc.
369,047$6.0B0.04%
62
HZNPHorizon Therapeutics Public Ltd Co
200,000$5.9B0.04%
63
HOOKGBPHOOKIPA Pharma Inc.
700,481$5.8B0.04%
64
OPHTEURIVERIC bio, Inc.
1,635,501$5.6B0.03%
65
CABACabaletta Bio, Inc.
636,363$4.6B0.03%
66
ArTara Therapeutics, Inc.
199,671$4.6B0.03%
67
Millendo Therapeutics, Inc.
833,333$4.4B0.03%
68
PASGPassage Bio, Inc.
275,000$4.3B0.03%
69
Constellation Pharmaceuticals, Inc.
133,333$4.2B0.03%
70
Immunomedics, Inc.
310,000$4.2B0.03%
71
NERVGBPMinerva Neurosciences, Inc.
688,531$4.1B0.03%
72
Syros Pharmaceuticals, Inc.
690,167$4.1B0.03%
73
CPRXCatalyst Pharmaceuticals, Inc.
1,060,714$4.1B0.03%
74
Abeona Therapeutics Inc.
1,590,686$3.3B0.02%
75
ANABAnaptysBio, Inc.
234,592$3.3B0.02%
76
Evofem Biosciences, Inc.
621,297$3.3B0.02%
77
Molecular Templates, Inc.
237,917$3.2B0.02%
78
NGMUSDNGM Biopharmaceuticals, Inc.
250,000$3.1B0.02%
79
ORTXUSDOrchard Therapeutics plc
405,702$3.1B0.02%
80
KRTXKaruna Therapeutics, Inc.
41,976$3.0B0.02%
81
VSAREURAravive, Inc.
486,333$2.8B0.02%
82
TPIVDEURMarker Therapeutics, Inc.
1,470,198$2.8B0.02%
83
CRNXCrinetics Pharmaceuticals, Inc.
175,000$2.6B0.02%
84
GLPGGalapagos NV
13,072$2.6B0.02%
85
XLRNAcceleron Pharma Inc.
27,000$2.4B0.01%
86
GBTUSDGlobal Blood Therapeutics, Inc.
47,000$2.4B0.01%
87
Harpoon Therapeutics, Inc.
204,467$2.4B0.01%
88
MTNBEURMatinas BioPharma Holdings, Inc.
3,754,221$2.3B0.01%
89
APLTApplied Therapeutics, Inc.
65,934$2.2B0.01%
90
VKTXViking Therapeutics, Inc.
425,000$2.0B0.01%
91
bluebird bio, Inc.
40,000$1.8B0.01%
92
DNLIDenali Therapeutics Inc.
104,900$1.8B0.01%
93
RCUSArcus Biosciences, Inc.
121,534$1.7B0.01%
94
Menlo Therapeutics Inc.
625,345$1.7B0.01%
95
NTLAIntellia Therapeutics, Inc.
128,538$1.6B0.01%
96
LPTXEURLeap Therapeutics, Inc.
978,454$1.5B0.01%
97
ARYA Sciences Acquisition Corp.
150,000$1.5B0.01%
98
Dicerna Pharmaceuticals, Inc.
81,935$1.5B0.01%
99
Bellicum Pharmaceuticals, Inc.
249,123$1.2B0.01%
100
GTHXEURG1 Therapeutics, Inc.
88,026$970.0M0.01%
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