BAKER BROS. ADVISORS LP Q3 2018 Filing

Filed November 14, 2018

Portfolio Value

$15.2T

Holdings

97

Report Date

Q3 2018

Filing Type

13F-HR

All Holdings (97 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
51,046,060$3.9T25.93%
2
INCYIncyte Corporation
34,251,309$2.4T15.59%
3
ONCBeiGene, Ltd.
11,959,824$2.1T13.57%
4
ALXNAlexion Pharmaceuticals, Inc.
8,555,894$1.2T7.83%
5
Genomic Health, Inc.
13,790,970$968.4B6.38%
6
BMRNBioMarin Pharmaceutical Inc.
7,583,084$735.3B4.84%
7
ACADACADIA Pharmaceuticals Inc.
28,439,114$590.4B3.89%
8
AMRNAmarin Corporation plc
34,069,509$554.3B3.65%
9
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$250.4B1.65%
10
ASNDAscendis Pharma A/S
2,837,352$201.1B1.32%
11
HRTXHeron Therapeutics, Inc.
5,025,298$159.1B1.05%
12
NVTA1EURInvitae Corporation
8,399,411$140.5B0.93%
13
DBV Technologies S.A.
5,509,560$123.7B0.82%
14
MRTXEURMirati Therapeutics, Inc.
2,513,462$118.4B0.78%
15
NBIXNeurocrine Biosciences, Inc.
944,624$116.1B0.77%
16
BCRXBioCryst Pharmaceuticals, Inc.
15,103,081$115.2B0.76%
17
ARRYEURArray BioPharma Inc.
5,656,196$86.0B0.57%
18
SG7Sage Therapeutics, Inc.
567,497$80.2B0.53%
19
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$79.0B0.52%
20
CERSCerus Corporation
10,749,937$77.5B0.51%
21
ARGXargenx SE
1,019,557$77.3B0.51%
22
KNSAKiniksa Pharmaceuticals, Ltd.
3,000,000$76.5B0.50%
23
Spark Therapeutics, Inc.
1,384,130$75.5B0.50%
24
GW Pharmaceuticals plc
396,700$68.5B0.45%
25
CBAYUSDCymaBay Therapeutics, Inc.
4,917,700$54.5B0.36%
26
Principia Biopharma Inc.
1,787,807$52.2B0.34%
27
1T7Tricida, Inc.
1,600,000$48.9B0.32%
28
Endocyte, Inc.
2,548,069$45.3B0.30%
29
Idera Pharmaceuticals, Inc.
4,833,897$43.1B0.28%
30
Corsicanto II Designated Activity Company
10,000,000$41.7B0.27%
31
IM8NInsmed Incorporated
1,851,982$37.4B0.25%
32
Aquinox Pharmaceuticals, Inc.
10,934,154$32.0B0.21%
33
Abeona Therapeutics Inc.
2,184,364$28.0B0.18%
34
SLDBSolid Biosciences Inc.
587,884$27.7B0.18%
35
GLPGGalapagos NV
237,191$26.7B0.18%
36
XNCRXencor, Inc.
602,495$23.5B0.15%
37
MyoKardia, Inc.
357,215$23.3B0.15%
38
MRUSMerus N.V.
1,160,014$22.9B0.15%
39
QUREuniQure N.V.
605,000$22.0B0.15%
40
GBYSangamo Therapeutics, Inc.
1,283,923$21.8B0.14%
41
Clementia Pharmaceuticals Inc.
1,933,624$21.6B0.14%
42
Zymeworks Inc.
1,311,085$20.6B0.14%
43
Aimmune Therapeutics, Inc.
673,908$18.4B0.12%
44
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
10,000,000$17.1B0.11%
45
Bellicum Pharmaceuticals, Inc.
2,677,818$16.5B0.11%
46
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$15.8B0.10%
47
Audentes Therapeutics, Inc.
393,222$15.6B0.10%
48
ContraFect Corporation
7,153,076$14.8B0.10%
49
AGLEUSDAeglea BioTherapeutics, Inc.
1,387,872$13.3B0.09%
50
BioMarin Pharmaceutical Inc.
12,228,000$12.6B0.08%
51
ANABAnaptysBio, Inc.
113,086$11.3B0.07%
52
CPRXCatalyst Pharmaceuticals, Inc.
2,900,000$11.0B0.07%
53
ERYP1EURERYTECH Pharma S.A.
1,085,969$9.3B0.06%
54
NVAXNovavax, Inc.
4,718,318$8.9B0.06%
55
bluebird bio, Inc.
59,441$8.7B0.06%
56
BDQMAlbireo Pharma, Inc.
250,000$8.2B0.05%
57
HALOHalozyme Therapeutics, Inc.
449,969$8.2B0.05%
58
Momenta Pharmaceuticals, Inc.
308,500$8.1B0.05%
59
VKTXViking Therapeutics, Inc.
425,000$7.4B0.05%
60
Spring Bank Pharmaceuticals, Inc.
613,144$7.4B0.05%
61
AUTLAutolus Therapeutics plc
235,294$7.2B0.05%
62
Menlo Therapeutics Inc.
700,000$6.9B0.05%
63
Syros Pharmaceuticals, Inc.
574,835$6.8B0.05%
64
GTHXEURG1 Therapeutics, Inc.
127,236$6.7B0.04%
65
IFRXInflaRx N.V.
178,987$6.1B0.04%
66
Achillion Pharmaceuticals, Inc.
1,639,948$6.0B0.04%
67
ARWRArrowhead Pharmaceuticals, Inc.
307,496$5.9B0.04%
68
ASMBAssembly Biosciences, Inc.
148,587$5.5B0.04%
69
NTLAIntellia Therapeutics, Inc.
192,538$5.5B0.04%
70
CCXIEURChemoCentryx, Inc.
414,029$5.2B0.03%
71
Aevi Genomic Medicine, Inc.
3,950,419$4.9B0.03%
72
XLRNAcceleron Pharma Inc.
83,900$4.8B0.03%
73
GLMDGalmed Pharmaceuticals Ltd.
324,094$4.4B0.03%
74
ALKSAlkermes plc
100,251$4.3B0.03%
75
YMABUSDY-mAbs Therapeutics, Inc.
150,000$4.0B0.03%
76
Foamix Pharmaceuticals Ltd.
688,075$3.9B0.03%
77
CRNXCrinetics Pharmaceuticals, Inc.
131,250$3.8B0.02%
78
Forty Seven, Inc.
250,000$3.7B0.02%
79
APLSApellis Pharmaceuticals, Inc.
196,078$3.5B0.02%
80
Adamas Pharmaceuticals, Inc.
172,630$3.5B0.02%
81
Versartis, Inc.
2,426,310$3.4B0.02%
82
Ra Pharmaceuticals, Inc.
177,952$3.2B0.02%
83
La Jolla Pharmaceutical Company
154,675$3.1B0.02%
84
TREURTrillium Therapeutics Inc.
505,262$2.9B0.02%
85
KRYSKrystal Biotech, Inc.
114,674$2.0B0.01%
86
AQSTAquestive Therapeutics, Inc.
99,600$1.7B0.01%
87
RCUSArcus Biosciences, Inc.
121,534$1.7B0.01%
88
INFIQInfinity Pharmaceuticals, Inc.
580,400$1.6B0.01%
89
Molecular Templates, Inc.
254,230$1.4B0.01%
90
OVIDOvid Therapeutics Inc.
222,139$1.3B0.01%
91
Sunesis Pharmaceuticals, Inc.
556,665$1.1B0.01%
92
DVAXDynavax Technologies Corporation
75,000$930.0M0.01%
93
Constellation Pharmaceuticals, Inc.
133,333$897.0M0.01%
94
Affimed N.V.
200,000$870.0M0.01%
95
Proteon Therapeutics, Inc.
298,591$582.0M0.00%
96
Ritter Pharmaceuticals, Inc.
279,999$521.0M0.00%
97
FLGTFulgent Genetics, Inc.
125,000$491.0M0.00%