BAKER BROS. ADVISORS LP Q3 2019 Filing

Filed November 14, 2019

Portfolio Value

$14.7T

Holdings

109

Report Date

Q3 2019

Filing Type

13F-HR

All Holdings (109 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
50,057,277$4.3T29.08%
2
INCYIncyte Corporation
31,976,557$2.4T16.15%
3
ACADACADIA Pharmaceuticals Inc.
40,854,586$1.5T10.00%
4
ONCBeiGene, Ltd.
11,777,285$1.4T9.81%
5
ALXNAlexion Pharmaceuticals, Inc.
8,258,068$808.8B5.50%
6
AMRNAmarin Corporation plc
41,544,288$629.8B4.28%
7
Genomic Health, Inc.
9,244,665$627.0B4.27%
8
BMRNBioMarin Pharmaceutical Inc.
7,589,294$511.5B3.48%
9
ASNDAscendis Pharma A/S
3,390,270$326.6B2.22%
10
NVTA1EURInvitae Corporation
8,792,678$169.4B1.15%
11
KODKodiak Sciences Inc.
9,145,116$131.5B0.89%
12
NBIXNeurocrine Biosciences, Inc.
1,415,283$127.5B0.87%
13
ARGXargenx SE
1,019,557$116.2B0.79%
14
HRTXHeron Therapeutics, Inc.
6,018,104$111.3B0.76%
15
MRTXEURMirati Therapeutics, Inc.
1,307,220$101.8B0.69%
16
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$100.8B0.69%
17
MyoKardia, Inc.
1,517,237$79.1B0.54%
18
Spark Therapeutics, Inc.
751,927$72.9B0.50%
19
1T7Tricida, Inc.
1,969,905$60.8B0.41%
20
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$58.5B0.40%
21
1K0IGM Biosciences, Inc.
3,144,000$55.8B0.38%
22
Ra Pharmaceuticals, Inc.
2,345,496$55.5B0.38%
23
CERSCerus Corporation
10,749,937$55.4B0.38%
24
DBV Technologies S.A.
5,509,560$47.4B0.32%
25
Principia Biopharma Inc.
1,654,029$46.7B0.32%
26
BCELAtreca, Inc.
3,532,760$43.2B0.29%
27
GW Pharmaceuticals plc
370,845$42.7B0.29%
28
Zymeworks Inc.
1,708,472$42.4B0.29%
29
Audentes Therapeutics, Inc.
1,506,438$42.3B0.29%
30
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$42.1B0.29%
31
IM8NInsmed Incorporated
2,229,760$39.3B0.27%
32
BCRXBioCryst Pharmaceuticals, Inc.
12,725,472$36.5B0.25%
33
ADPTAdaptive Biotechnologies Corporation
1,165,411$36.0B0.24%
34
KRYSKrystal Biotech, Inc.
1,034,674$35.9B0.24%
35
Neoleukin Therapeutics, Inc.
11,305,679$32.2B0.22%
36
CBAYUSDCymaBay Therapeutics, Inc.
5,707,411$29.2B0.20%
37
ALLKGUSDAllakos Inc.
339,690$26.7B0.18%
38
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$23.8B0.16%
39
MRUSMerus N.V.
1,160,014$20.7B0.14%
40
QUREuniQure N.V.
517,700$20.4B0.14%
41
URGNUroGen Pharma Ltd.
747,751$17.8B0.12%
42
AXSMAxsome Therapeutics, Inc.
772,286$15.6B0.11%
43
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$14.7B0.10%
44
XNCRXencor, Inc.
428,120$14.4B0.10%
45
Aimmune Therapeutics, Inc.
673,908$14.1B0.10%
46
PTGXProtagonist Therapeutics, Inc.
1,174,282$14.1B0.10%
47
La Jolla Pharmaceutical Company
1,559,231$13.7B0.09%
48
Idera Pharmaceuticals, Inc.
4,608,786$13.3B0.09%
49
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$13.2B0.09%
50
ALKSAlkermes plc
625,030$12.2B0.08%
51
Syros Pharmaceuticals, Inc.
974,835$10.1B0.07%
52
GBYSangamo Therapeutics, Inc.
999,823$9.0B0.06%
53
ASMBAssembly Biosciences, Inc.
803,246$7.9B0.05%
54
TPIVDEURMarker Therapeutics, Inc.
1,500,000$7.7B0.05%
55
APLSApellis Pharmaceuticals, Inc.
313,725$7.6B0.05%
56
CPRXCatalyst Pharmaceuticals, Inc.
1,341,902$7.1B0.05%
57
HOOKGBPHOOKIPA Pharma Inc.
892,857$6.7B0.05%
58
Acorda Therapeutics, Inc.
2,232,589$6.4B0.04%
59
Dermira, Inc.
906,943$5.8B0.04%
60
XBITXbiotech Inc.
521,327$5.5B0.04%
61
BDQMAlbireo Pharma, Inc.
250,000$5.0B0.03%
62
VSAREURAravive, Inc.
664,088$5.0B0.03%
63
MISTMilestone Pharmaceuticals Inc.
266,667$5.0B0.03%
64
ORTXUSDOrchard Therapeutics plc
405,702$4.8B0.03%
65
HALOHalozyme Therapeutics, Inc.
299,969$4.7B0.03%
66
NXTCNextCure, Inc.
150,000$4.6B0.03%
67
IFRXInflarx N.V.
1,778,415$4.4B0.03%
68
ANABAnaptysBio, Inc.
113,086$4.0B0.03%
69
Achillion Pharmaceuticals, Inc.
1,095,359$3.9B0.03%
70
GLPGGalapagos NV
25,072$3.8B0.03%
71
bluebird bio, Inc.
40,000$3.7B0.02%
72
NGMUSDNGM Biopharmaceuticals, Inc.
250,000$3.5B0.02%
73
MIRMMirum Pharmaceuticals, Inc.
333,333$3.4B0.02%
74
XLRNAcceleron Pharma Inc.
83,900$3.3B0.02%
75
Menlo Therapeutics Inc.
700,000$3.1B0.02%
76
Harpoon Therapeutics, Inc.
214,285$2.9B0.02%
77
VKTXViking Therapeutics, Inc.
425,000$2.9B0.02%
78
Abeona Therapeutics Inc.
1,288,235$2.9B0.02%
79
GTHXEURG1 Therapeutics, Inc.
127,236$2.9B0.02%
80
Dova Pharmaceuticals, Inc.
102,205$2.9B0.02%
81
Bellicum Pharmaceuticals, Inc.
2,677,818$2.8B0.02%
82
YMABUSDY-mAbs Therapeutics, Inc.
102,800$2.7B0.02%
83
CRNXCrinetics Pharmaceuticals, Inc.
175,000$2.6B0.02%
84
Cyclerion Therapeutics, Inc.
202,581$2.5B0.02%
85
Spring Bank Pharmaceuticals, Inc.
613,144$2.1B0.01%
86
AUTLAutolus Therapeutics plc
156,773$1.9B0.01%
87
IDYAIDEAYA Biosciences, Inc.
200,000$1.8B0.01%
88
NTLAIntellia Therapeutics, Inc.
128,538$1.7B0.01%
89
Molecular Templates, Inc.
254,230$1.7B0.01%
90
Forty Seven, Inc.
250,000$1.6B0.01%
91
Foamix Pharmaceuticals Ltd.
498,189$1.5B0.01%
92
CTMXCytomX Therapeutics, Inc.
194,377$1.4B0.01%
93
CCXIEURChemoCentryx, Inc.
207,029$1.4B0.01%
94
FLGTFulgent Genetics, Inc.
125,000$1.3B0.01%
95
MTNBEURMatinas BioPharma Holdings, Inc.
1,984,965$1.3B0.01%
96
LPTXEURLeap Therapeutics, Inc.
978,454$1.1B0.01%
97
RCUSArcus Biosciences, Inc.
121,534$1.1B0.01%
98
GLMDGalmed Pharmaceuticals Ltd.
215,594$1.0B0.01%
99
Adamas Pharmaceuticals, Inc.
172,630$883.0M0.01%
100
Constellation Pharmaceuticals, Inc.
133,333$861.0M0.01%
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