Who Owns Edgewise Therapeutics, Inc. (EWTX)?Hedge Fund & Institutional Holders

$29.45-0.49 (-1.64%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+3 / -6

Price History

$11.42$17.72$24.02$30.32$36.62Sep 24Jun 25Mar 26

EWTX — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
DRIEHAUS CAPITAL MANAGEMENT LLCIncreased+2.0M+$67.9B
UBS Group AGIncreased+2.0M+$50.7B
Siren, L.L.C.Increased+633K+$49.2B
PERCEPTIVE ADVISORS LLCIncreased+662K+$49.1B
BANK OF AMERICA CORP /DE/Increased+1.2M+$36.0B
ALLIANCEBERNSTEIN L.P.Increased+959K+$23.7B
Soleus Capital Management, L.P.New Position+910K+$22.6B
FMR LLCIncreased+440K+$17.0B
First Light Asset Management, LLCIncreased+159K+$16.1B
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUNDNew Position+640K+$15.0B
AMERICAN CENTURY COMPANIES INCIncreased+91K+$11.2B
Aberdeen Group plcIncreased+202K+$10.3B
VICTORY CAPITAL MANAGEMENT INCIncreased+248K+$9.9B
STEMPOINT CAPITAL LPNew Position+361K+$9.0B
DIMENSIONAL FUND ADVISORS LPIncreased+31K+$8.8B

EWTX — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
New Leaf Venture Partners, L.L.C.Closed Position-1.0M-$16.7B
Qube Research & Technologies LtdDecreased-260K-$9.0B
MILLENNIUM MANAGEMENT LLCDecreased-599K-$8.8B
Bellevue Group AGDecreased-1.2M-$7.1B
TANG CAPITAL MANAGEMENT LLCClosed Position-431K-$7.0B
Kynam Capital Management, LPClosed Position-254K-$4.1B
CITIGROUP INCDecreased-315K-$3.7B
D. E. Shaw & Co., Inc.Decreased-283K-$2.0B
Neuberger Berman Group LLCDecreased-93K-$1.6B
Squarepoint Ops LLCClosed Position-75K-$1.2B
JANE STREET GROUP, LLCClosed Position-70K-$1.1B
Legal & General Group PlcDecreased-3K-$907.4M
MetLife Investment Management, LLCDecreased-6K-$711.8M
SEI INVESTMENTS CODecreased-8K-$634.1M
Trexquant Investment LPClosed Position-23K-$367.0M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1ORBIMED ADVISORS LLC15,518,492$385.1B7.86%Share
2BAKER BROS. ADVISORS LP6,575,940$163.2B955.47%Share
3Novo Holdings A/S5,350,000$132.8B10.31%Share
4Siren, L.L.C.4,529,990$112.4B3.35%Share
5JANUS HENDERSON GROUP PLC4,475,646$111.0B49.71%Share
6PERCEPTIVE ADVISORS LLC4,457,974$110.6B1971.81%Share
7DRIEHAUS CAPITAL MANAGEMENT LLC4,191,193$104.0B706.45%Share
8Cormorant Asset Management, LP3,285,000$81.5B3.77%Share
9UBS Group AG2,116,913$52.5B8.52%Share
10First Light Asset Management, LLC1,573,701$39.1B2.99%Share
11Bellevue Group AG1,528,518$37.9B718.79%Share
12Integral Health Asset Management, LLC1,500,000$37.2B1.85%Share
13BANK OF AMERICA CORP /DE/1,412,966$35.0B2.55%Share
14AMERICAN CENTURY COMPANIES INC1,186,467$29.0B14.58%Share
15DIMENSIONAL FUND ADVISORS LP1,120,267$27.0B5.66%Share
16ALLIANCEBERNSTEIN L.P.1,036,170$25.0B7.89%Share
17Soleus Capital Management, L.P.910,000$22.6B0.83%Share
18Aberdeen Group plc821,940$20.4B31.58%Share
19DEERFIELD MANAGEMENT COMPANY, L.P.765,694$19.0B242.65%Share
20VICTORY CAPITAL MANAGEMENT INC746,562$18.0B10.16%Share
21Artisan Partners Limited Partnership704,077$17.0B25.45%Share
22FMR LLC692,698$17.0B0.87%Share
23CHARLES SCHWAB INVESTMENT MANAGEMENT INC611,384$15.0B2.33%Share
24HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND640,400$15.0B25.09%Share
25EVENTIDE ASSET MANAGEMENT, LLC568,310$14.1B220.29%Share
26GOLDMAN SACHS GROUP INC536,948$13.0B1.60%Share
27Candriam S.C.A.501,214$12.0B59.76%Share
28NORTHERN TRUST CORP514,615$12.0B1.53%Share
29Sofinnova Investments, Inc.437,819$10.9B0.47%Share
30BARCLAYS PLC372,703$9.0B2.16%Share
31D. E. Shaw & Co., Inc.394,695$9.0B4.93%Share
32STEMPOINT CAPITAL LP360,876$9.0B1.54%Share
33Eversept Partners, LP337,340$8.4B0.42%Share
34Universal- Beteiligungs- und Servicegesellschaft mbH271,385$6.7B10.93%Share
35KENNEDY CAPITAL MANAGEMENT LLC241,509$6.0B0.13%Share
36Sio Capital Management, LLC237,481$5.9B0.93%Share
37Granahan Investment Management, LLC232,295$5.8B0.25%Share
38Ally Bridge Group (NY) LLC225,800$5.6B5.84%Put
39AMERIPRISE FINANCIAL INC201,897$5.0B1.13%Share
40CITIGROUP INC221,767$5.0B2.21%Share
41Woodline Partners LP224,192$5.0B19.37%Share
42Ally Bridge Group (NY) LLC195,000$4.8B5.04%Share
43HighVista Strategies LLC171,137$4.0B1.03%Share
44GOLDMAN SACHS GROUP INC181,424$4.0B0.49%Share
45Caption Management, LLC125,800$3.1B21.40%Put
46SCHRODER INVESTMENT MANAGEMENT GROUP145,286$3.0B2.27%Share
47BALYASNY ASSET MANAGEMENT L.P.151,905$3.0B3.81%Share
48CITADEL ADVISORS LLC123,097$3.0B0.45%Share
49DEUTSCHE BANK AG\158,000$3.0B0.98%Share
50MILLENNIUM MANAGEMENT LLC126,436$3.0B1.26%Share

EWTX Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025194$1.8T+54
Q3 2025140$1.4T-8
Q2 2025148$1.1T-44
Q1 2025192$2.0T-4
Q4 2024196$2.3T+42
Q3 2024154$95.0T+24
Q2 2024130$14.6T+18
Q1 2024112$498.8T—

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As of Q4 2025, 50 institutional investors hold EWTX (Edgewise Therapeutics, Inc.). The largest holder is ORBIMED ADVISORS LLC with $385.1B in shares. This quarter, 3 institutions opened new positions and 6 closed their positions.

Frequently Asked Questions

How many hedge funds own EWTX?

As of Q4 2025, 50 institutional investors report holding EWTX (Edgewise Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of EWTX?

The largest institutional holder of EWTX is ORBIMED ADVISORS LLC with $385.1B in shares.

Is institutional ownership of EWTX increasing or decreasing?

This quarter, 3 institutions opened new positions in EWTX and 6 closed their positions.