ORBIMED ADVISORS LLC

CIK: 0001055951SEC EDGAR →

Portfolio Value

$4.9B

Holdings

105

As of

Q4 2025

New Positions

21

Closed Positions

14

Top 10 Holdings

RankStockSharesValue% of Portfolio
1

EDGEWISE THERAPEUTICS INC

15,518,492$385.1M
7.86%
2

ELI LILLY & CO

301,200$323.7M
6.61%
3

BOSTON SCIENTIFIC CORP

2,419,300$230.7M
4.71%
4

SINOVAC BIOTECH LTD

2,718,735$184.5M
3.77%
5
EWCall

EDWARDS LIFESCIENCES CORP

1,992,900$169.9M
3.47%
6

UPSTREAM BIO INC

5,693,589$154.6M
3.16%
7

INTUITIVE SURGICAL INC

263,400$149.2M
3.04%
8

SIONNA THERAPEUTICS INC

3,561,655$146.5M
2.99%
9

MBX BIOSCIENCES INC

3,935,203$124.1M
2.53%
10

ARGENX SE

146,000$122.8M
2.51%

Quarterly Changes

Top Buys

BSXNEW
$230.7M
EWNEW
$169.9M
APLSNEW
$61.0M
GPCR↑ Increased
$48.9M
CRNXNEW
$46.5M

Top Sells

DIH HLDG US INCCLOSED
$358.1M
BSXCLOSED
$256.7M
EWCLOSED
$131.0M
APLSCLOSED
$58.2M
MBX↓ Decreased
$54.1M

New Positions (29)

$230.7M · 2.4M shares
$169.9M · 2.0M shares
$61.0M · 2.4M shares
$46.5M · 999K shares
$41.8M · 775K shares
$41.2M · 1.7M shares
$34.7M · 99K shares
$31.4M · 3.8M shares
$27.9M · 95K shares
$26.2M · 556K shares
$22.1M · 6.0M shares
$21.1M · 2.1M shares
$18.3M · 489K shares
$17.9M · 354K shares
$13.2M · 371K shares
$12.6M · 2.6M shares
$12.0M · 575K shares
$8.7M · 1.0M shares
$7.7M · 187K shares
$6.2M · 382K shares
$5.7M · 205K shares
$4.4M · 1.9M shares
$3.5M · 209K shares
$2.1M · 26K shares
$1.9M · 157K shares
$1.9M · 22K shares
$1.8M · 23K shares
$1.2M · 1.0M shares
$952K · 56K shares

Closed Positions (28)

DIH HLDG US INC
$358.1M · 1.9M shares
$256.7M · 2.6M shares
$131.0M · 1.7M shares
$58.2M · 2.6M shares
$49.9M · 1.2M shares
$38.0M · 2.6M shares
$34.4M · 6.1M shares
$30.0M · 290K shares
$25.0M · 526K shares
$20.1M · 150K shares
$12.7M · 500K shares
$12.2M · 414K shares
$11.5M · 150K shares
$10.2M · 751K shares
$9.3M · 11.4M shares
$7.8M · 888K shares
$6.4M · 3.2M shares
$4.0M · 467K shares
$3.7M · 100K shares
$3.6M · 100K shares
$2.7M · 2.0M shares
$1.8M · 347K shares
$1.6M · 32K shares
$1.2M · 589K shares
$840K · 52K shares
$752K · 193K shares
$655K · 80K shares
$474K · 59K shares

Sector Breakdown

Sector# HoldingsValue%
Healthcare101$4.8B98.1%
Unknown5$91.1M1.9%