| 1 | Point72 Asset Management, L.P. | 4,432,559 | $36.0M | 0.04% | Share |
| 2 | ORBIMED ADVISORS LLC | 3,840,500 | $31.4M | 0.64% | Share |
| 3 | VR Adviser, LLC | 3,840,250 | $31.4M | 1.55% | Share |
| 4 | Deep Track Capital, LP | 1,854,255 | $15.2M | 0.27% | Share |
| 5 | Rosalind Advisors, Inc. | 1,657,540 | $13.6M | 4.77% | Share |
| 6 | ACORN CAPITAL ADVISORS, LLC | 1,573,023 | $12.9M | 4.36% | Share |
| 7 | EVENTIDE ASSET MANAGEMENT, LLC | 1,257,000 | $10.3M | 0.16% | Share |
| 8 | MILLENNIUM MANAGEMENT LLC | 1,028,549 | $8.0M | 0.00% | Share |
| 9 | MORGAN STANLEY | 990,991 | $8.0M | 0.00% | Share |
| 10 | SPHERA FUNDS MANAGEMENT LTD. | 825,576 | $6.8M | 1.31% | Share |
| 11 | DCF Advisers, LLC | 775,588 | $6.3M | 1.70% | Share |
| 12 | Spruce Street Capital LP | 770,000 | $6.3M | 2.08% | Share |
| 13 | CITADEL ADVISORS LLC | 771,376 | $6.0M | 0.00% | Share |
| 14 | Boxer Capital Management, LLC | 715,000 | $5.8M | 1.28% | Share |
| 15 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | $5.0M | 0.01% | Share |
| 16 | ArrowMark Colorado Holdings LLC | 598,419 | $4.9M | 0.11% | Share |
| 17 | Squadron Capital Management LLC | 525,000 | $4.3M | 1.82% | Share |
| 18 | Nan Fung Group Holdings Ltd | 460,000 | $3.8M | 3.37% | Share |
| 19 | DAFNA Capital Management LLC | 455,018 | $3.7M | 0.86% | Share |
| 20 | Stonepine Capital Management, LLC | 339,902 | $2.8M | 2.03% | Share |
| 21 | Knott David M Jr | 285,182 | $2.3M | 1.08% | Share |
| 22 | DLD Asset Management, LP | 283,600 | $2.3M | 0.17% | Call |
| 23 | PEAK6 LLC | 204,899 | $2.0M | 0.00% | Share |
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 300,230 | $2.0M | 0.00% | Share |
| 25 | MORGAN STANLEY | 301,984 | $2.0M | 0.00% | Share |
| 26 | ADAR1 Capital Management, LLC | 238,390 | $1.9M | 0.14% | Share |
| 27 | UBS Group AG | 217,037 | $1.8M | 0.00% | Share |
| 28 | Pale Fire Capital SE | 153,505 | $1.3M | 0.08% | Share |
| 29 | Ikarian Capital, LLC | 132,153 | $1.1M | 0.08% | Share |
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 196,100 | $1.0M | 0.00% | Call |
| 31 | NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 35,402 | $820K | 0.00% | Share |
| 32 | Fore Capital, LLC | 66,421 | $543K | 0.18% | Share |
| 33 | GROUP ONE TRADING LLC | 45,400 | $371K | 0.00% | Call |
| 34 | PDS Planning, Inc | 30,344 | $248K | 0.02% | Share |
| 35 | MYDA Advisors LLC | 30,000 | $245K | 0.05% | Share |
| 36 | Diametric Capital, LP | 17,758 | $145K | 0.04% | Share |
| 37 | GROUP ONE TRADING LLC | 10,725 | $87K | 0.00% | Share |
| 38 | UBS Group AG | 7,779 | $63K | 0.00% | Share |
| 39 | UBS Group AG | 7,463 | $61K | 0.00% | Share |
| 40 | IAG Wealth Partners, LLC | 2,750 | $22K | 0.00% | Share |
| 41 | North Star Investment Management Corp. | 2,500 | $20K | 0.00% | Share |
| 42 | TD Waterhouse Canada Inc. | 2,033 | $16K | 0.00% | Share |
| 43 | UBS Group AG | 1,435 | $11K | 0.00% | Share |
| 44 | Global Wealth Strategies & Associates | 526 | $4K | 0.00% | Share |
| 45 | GROUP ONE TRADING LLC | 400 | $3K | 0.00% | Put |
| 46 | HARBOUR INVESTMENTS, INC. | 250 | $2K | 0.00% | Share |
| 47 | Farther Finance Advisors, LLC | 247 | $2K | 0.00% | Share |
| 48 | Atlantic Edge Private Wealth Management, LLC | 137 | $1K | 0.00% | Share |
| 49 | Avalon Trust Co | 197 | $1K | 0.00% | Share |
| 50 | Tidemark, LLC | 131 | $1K | 0.00% | Share |