SPHERA FUNDS MANAGEMENT LTD.

CIK: 0001496201SEC EDGAR →

Portfolio Value

$628K

Holdings

98

As of

Q4 2025

New Positions

23

Closed Positions

21

Top 10 Holdings

RankStockSharesValue% of Portfolio
1

MEREO BIOPHARMA GROUP PLC

255,400$106K
16.88%
2

TEVA PHARMACEUTICAL INDS LTD

1,123,525$35K
5.58%
3

BIOGEN INC

94,738$17K
2.65%
4

MINERALYS THERAPEUTICS INC

449,003$16K
2.59%
5

SYNDAX PHARMACEUTICALS INC

762,563$16K
2.55%
6

NOVA LTD

47,846$16K
2.50%
7
RARECall

ULTRAGENYX PHARMACEUTICAL IN

650,623$15K
2.38%
8

TOWER SEMICONDUCTOR LTD

122,513$14K
2.29%
9

COGENT BIOSCIENCES INC

378,500$13K
2.14%
10

ASTRAZENECA PLC

135,060$12K
1.98%

Quarterly Changes

Top Buys

MREONEW
$106K
RARENEW
$15K
COGT↑ Increased
$12K
SNDX↑ Increased
$10K
BMRNNEW
$9K

Top Sells

PMNEURCLOSED
$125K
NSYCLOSED
$23K
CDTXCLOSED
$17K
MRUSCLOSED
$14K
RARECLOSED
$11K

New Positions (30)

$106K · 255K shares
$15K · 651K shares
$9K · 147K shares
$9K · 70K shares
$8K · 108K shares
$7K · 599K shares
$7K · 158K shares
$7K · 838K shares
$6K · 56K shares
$5K · 410K shares
$5K · 176K shares
$5K · 545K shares
$3K · 650K shares
$3K · 2.1M shares
$3K · 243K shares
$3K · 136K shares
$3K · 41K shares
$3K · 166K shares
$2K · 124K shares
$2K · 11K shares
$2K · 190K shares
$2K · 173K shares
$2K · 3K shares
$2K · 396K shares
$1K · 111K shares
$1K · 1.5M shares
$712 · 195K shares
$432 · 184K shares
$355 · 123K shares
$80 · 12K shares

Closed Positions (37)

$125K · 295K shares
$23K · 157K shares
$17K · 176K shares
$14K · 150K shares
$11K · 353K shares
$9K · 171K shares
$7K · 773K shares
$6K · 224K shares
$6K · 100K shares
$6K · 299K shares
$5K · 158K shares
$4K · 257K shares
$4K · 1.5M shares
$3K · 504K shares
$3K · 364K shares
$3K · 14K shares
$3K · 194K shares
$3K · 150K shares
$3K · 29K shares
$3K · 100K shares
$2K · 102K shares
$2K · 81K shares
$2K · 116K shares
$2K · 50K shares
$2K · 147K shares
$2K · 820K shares
$1K · 91K shares
$1K · 86K shares
$1K · 566K shares
$841 · 260K shares
$583 · 40K shares
$580 · 81K shares
$471 · 179K shares
$430 · 12K shares
$165 · 22K shares
$13 · 23K shares
$2 · 4K shares

Sector Breakdown

Sector# HoldingsValue%
Healthcare76$501K79.7%
Unknown8$49K7.8%
Technology6$43K6.9%
Financial Services4$18K2.8%
Energy2$12K1.9%
Industrials2$6K1.0%