| 1 | BAKER BROS. ADVISORS LP | 12,094,094 | $127.0M | 0.74% | Share |
| 2 | RTW INVESTMENTS, LP | 11,433,354 | $120.0M | 1.20% | Share |
| 3 | SUVRETTA CAPITAL MANAGEMENT, LLC | 11,190,129 | $117.5M | 2.41% | Share |
| 4 | PERCEPTIVE ADVISORS LLC | 10,383,456 | $109.0M | 1.94% | Share |
| 5 | Vestal Point Capital, LP | 6,125,000 | $64.3M | 2.19% | Share |
| 6 | Jefferies Financial Group Inc. | 5,059,551 | $53.0M | 0.27% | Share |
| 7 | T. Rowe Price Investment Management, Inc. | 4,789,996 | $50.3M | 0.05% | Share |
| 8 | Sofinnova Investments, Inc. | 3,435,542 | $36.1M | 1.56% | Share |
| 9 | MORGAN STANLEY | 2,041,131 | $21.0M | 0.00% | Share |
| 10 | Point72 Asset Management, L.P. | 1,754,181 | $18.0M | 0.02% | Share |
| 11 | CITADEL ADVISORS LLC | 1,714,961 | $18.0M | 0.00% | Share |
| 12 | WELLINGTON MANAGEMENT GROUP LLP | 1,106,453 | $11.0M | 0.00% | Share |
| 13 | Woodline Partners LP | 1,000,597 | $10.0M | 0.04% | Share |
| 14 | Lynx1 Capital Management LP | 921,950 | $9.7M | 1.96% | Share |
| 15 | SPHERA FUNDS MANAGEMENT LTD. | 861,105 | $9.0M | 1.75% | Share |
| 16 | Caption Management, LLC | 850,000 | $8.9M | 0.06% | Call |
| 17 | Logos Global Management LP | 850,000 | $8.9M | 0.54% | Call |
| 18 | Alyeska Investment Group, L.P. | 789,163 | $8.0M | 0.02% | Share |
| 19 | Aberdeen Group plc | 714,569 | $7.5M | 0.01% | Share |
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 748,035 | $7.0M | 0.00% | Share |
| 21 | UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 697,431 | $7.0M | 0.99% | Share |
| 22 | STEMPOINT CAPITAL LP | 610,308 | $6.4M | 1.10% | Share |
| 23 | BALYASNY ASSET MANAGEMENT L.P. | 592,428 | $6.0M | 0.01% | Share |
| 24 | UBS Group AG | 560,946 | $5.9M | 0.00% | Share |
| 25 | Caption Management, LLC | 550,891 | $5.8M | 0.04% | Share |
| 26 | WASATCH ADVISORS LP | 515,128 | $5.4M | 0.03% | Share |
| 27 | WELLINGTON MANAGEMENT GROUP LLP | 510,022 | $5.0M | 0.00% | Share |
| 28 | TD ASSET MANAGEMENT INC | 500,724 | $5.0M | 0.00% | Share |
| 29 | STATE STREET CORP | 444,658 | $4.0M | 0.00% | Share |
| 30 | SCHRODER INVESTMENT MANAGEMENT GROUP | 402,352 | $4.0M | 0.00% | Share |
| 31 | GOLDMAN SACHS GROUP INC | 323,023 | $3.0M | 0.00% | Share |
| 32 | DAFNA Capital Management LLC | 261,138 | $2.7M | 0.64% | Share |
| 33 | SG Americas Securities, LLC | 208,456 | $2.2M | 0.00% | Share |
| 34 | Verition Fund Management LLC | 206,568 | $2.0M | 0.01% | Share |
| 35 | Monashee Investment Management LLC | 160,336 | $1.7M | 0.95% | Share |
| 36 | Burkehill Global Management, LP | 150,000 | $1.6M | 0.10% | Share |
| 37 | MYDA Advisors LLC | 120,000 | $1.3M | 0.24% | Share |
| 38 | SummitTX Capital, L.P. | 96,784 | $1.0M | 0.03% | Share |
| 39 | BNP PARIBAS FINANCIAL MARKETS | 116,646 | $1.0M | 0.00% | Share |
| 40 | ALPS ADVISORS INC | 110,082 | $1.0M | 0.01% | Share |
| 41 | NORTHERN TRUST CORP | 188,601 | $1.0M | 0.00% | Share |
| 42 | Qube Research & Technologies Ltd | 147,328 | $1.0M | 0.00% | Share |
| 43 | JPMORGAN CHASE & CO | 146,972 | $1.0M | 0.00% | Share |
| 44 | GEODE CAPITAL MANAGEMENT, LLC | 134,763 | $1.0M | 0.00% | Share |
| 45 | JANE STREET GROUP, LLC | 104,633 | $1.0M | 0.00% | Share |
| 46 | Ishara Investments LP | 80,000 | $840K | 0.96% | Share |
| 47 | SECTORAL ASSET MANAGEMENT INC | 63,015 | $661K | 0.53% | Share |
| 48 | Ikarian Capital, LLC | 48,569 | $509K | 0.04% | Share |
| 49 | Longaeva Partners L.P. | 44,601 | $468K | 0.04% | Share |
| 50 | Virtus Investment Advisers, LLC | 26,497 | $278K | 0.08% | Share |