| 1 | RA CAPITAL MANAGEMENT, L.P. | 10,689,545 | $15.0T | 100.00% | — |
| 2 | Point72 Asset Management, L.P. | 2,675,937 | $3.8T | 8.58% | — |
| 3 | SUVRETTA CAPITAL MANAGEMENT, LLC | 1,660,932 | $2.3T | 0.09% | — |
| 4 | VIKING GLOBAL INVESTORS LP | 1,482,434 | $2.1T | 6.62% | — |
| 5 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,350,000 | $1.9T | 3.51% | — |
| 6 | BlackRock, Inc. | 1,294,253 | $1.8T | 0.04% | — |
| 7 | MILLENNIUM MANAGEMENT LLC | 1,033,018 | $1.5T | 0.77% | — |
| 8 | Laurion Capital Management LP | 810,761 | $1.1T | 0.03% | — |
| 9 | Woodline Partners LP | 780,897 | $1.1T | 7.14% | — |
| 10 | GEODE CAPITAL MANAGEMENT, LLC | 383,893 | $538.0B | 0.04% | — |
| 11 | Ikarian Capital, LLC | 150,000 | $210.8B | 0.03% | — |
| 12 | NORTHERN TRUST CORP | 141,039 | $198.2B | 0.03% | — |
| 13 | Nuveen, LLC | 98,701 | $138.7B | 0.04% | — |
| 14 | AQR CAPITAL MANAGEMENT LLC | 87,003 | $122.2B | 0.13% | — |
| 15 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 75,608 | $106.2B | 0.02% | — |
| 16 | MORGAN STANLEY | 64,806 | $89.0B | 0.01% | — |
| 17 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 56,923 | $80.0B | 0.00% | — |
| 18 | DIMENSIONAL FUND ADVISORS LP | 54,629 | $76.9B | 0.02% | — |
| 19 | DEUTSCHE BANK AG\ | 48,518 | $68.4B | 0.03% | — |
| 20 | TWO SIGMA INVESTMENTS, LP | 46,194 | $64.9B | 0.14% | — |
| 21 | BOOTHBAY FUND MANAGEMENT, LLC | 45,570 | $64.0B | 0.00% | — |
| 22 | RENAISSANCE TECHNOLOGIES LLC | 45,300 | $63.6B | 0.10% | — |
| 23 | GOLDMAN SACHS GROUP INC | 40,240 | $56.5B | 0.01% | — |
| 24 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,070 | $56.3B | 0.01% | — |
| 25 | ZACKS INVESTMENT MANAGEMENT | 38,047 | $53.5B | 0.50% | — |
| 26 | UBS Group AG | 34,269 | $48.1B | 0.01% | — |
| 27 | Rathbones Group PLC | 32,003 | $45.0B | 0.22% | — |
| 28 | STRS OHIO | 10,200 | $38.7B | 0.15% | — |
| 29 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 26,559 | $37.3B | 0.00% | — |
| 30 | BARCLAYS PLC | 22,043 | $31.0B | 0.01% | — |
| 31 | ADAR1 Capital Management, LLC | 20,352 | $28.6B | 0.01% | — |
| 32 | RHUMBLINE ADVISERS | 19,071 | $26.8B | 0.03% | — |
| 33 | BANK OF AMERICA CORP /DE/ | 18,722 | $26.0B | 0.00% | — |
| 34 | XTX Topco Ltd | 18,139 | $25.5B | 0.00% | — |
| 35 | ALLIANCEBERNSTEIN L.P. | 17,650 | $24.8B | 0.01% | — |
| 36 | Rangeley Capital, LLC | 15,000 | $21.1B | 0.02% | — |
| 37 | CITIGROUP INC | 12,402 | $17.4B | 0.01% | — |
| 38 | Vanguard Personalized Indexing Management, LLC | 10,600 | $14.9B | 0.22% | — |
| 39 | GROUP ONE TRADING LLC | 9,900 | $13.9B | 0.04% | — |
| 40 | MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,289 | $13.1B | 0.03% | — |
| 41 | WELLS FARGO & COMPANY/MN | 7,639 | $10.7B | 0.00% | — |
| 42 | Corebridge Financial, Inc. | 7,610 | $10.7B | 0.06% | — |
| 43 | NEW YORK STATE COMMON RETIREMENT FUND | 6,485 | $9.0B | 0.01% | — |
| 44 | Tower Research Capital LLC (TRC) | 6,159 | $8.7B | 0.00% | — |
| 45 | Police & Firemen's Retirement System of New Jersey | 3,123 | $4.4B | 0.04% | — |
| 46 | Russell Investments Group, Ltd. | 2,740 | $3.9B | 0.01% | — |
| 47 | Legal & General Group Plc | 1,678 | $2.4B | 0.00% | — |
| 48 | Ameritas Investment Partners, Inc. | 1,175 | $1.7B | 0.00% | — |
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,126 | $1.6B | 0.00% | — |
| 50 | Mirae Asset Global Investments Co., Ltd. | 1,021 | $1.5B | 0.01% | — |