Opaleye Management Inc.
CIK: 0001595855SEC EDGAR →
Portfolio Value
$758.0M
Holdings
54
As of
Q4 2025
New Positions
11
Closed Positions
8
Top 10 Holdings
| Rank | Stock | Shares | Value | % of Portfolio |
|---|---|---|---|---|
| 1 | HARROW HEALTH INC | 3,905,000 | $191.3M | 25.24% |
| 2 | LIQUIDIA CORPORATION | 2,435,000 | $85.0M | 11.21% |
| 3 | ETON PHARMACEUTICALS INC | 2,860,000 | $48.4M | 6.38% |
| 4 | RHYTHM PHARMACEUTICALS INC | 330,000 | $35.3M | 4.66% |
| 5 | APOGEE THERAPEUTICS INC | 388,257 | $29.3M | 3.87% |
| 6 | SANUWAVE HEALTH INC | 981,267 | $29.3M | 3.86% |
| 7 | STOKE THERAPEUTICS INC | 695,000 | $22.1M | 2.91% |
| 8 | OCULAR THERAPEUTIX INC | 1,595,000 | $19.4M | 2.55% |
| 9 | SOL GEL TECHNOLOGIES | 453,739 | $19.1M | 2.52% |
| 10 | CG ONCOLOGY INC | 410,000 | $17.0M | 2.25% |
Quarterly Changes
Top Buys
New Positions (21)
$14.0M · 1.2M shares
$6.8M · 930K shares
$6.6M · 428K shares
$6.3M · 268K shares
$5.0M · 1.2M shares
$4.7M · 1.2M shares
$4.5M · 935K shares
$4.5M · 215K shares
$4.0M · 1.1M shares
$3.4M · 955K shares
$3.1M · 391K shares
$2.6M · 285K shares
$2.3M · 252K shares
$2.2M · 191K shares
$1.8M · 310K shares
$1.4M · 18K shares
$1.2M · 75K shares
$708K · 213K shares
$641K · 180K shares
$479K · 79K shares
$213K · 150K shares
Sector Breakdown
| Sector | # Holdings | Value | % |
|---|---|---|---|
| Healthcare | 52 | $741.5M | 97.8% |
| Financial Services | 1 | $13.5M | 1.8% |
| Unknown | 1 | $3.0M | 0.4% |