Who Owns Pyxis Oncology, Inc. (PYXS)?Hedge Fund & Institutional Holders

$1.53+0.01 (+0.33%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$6.8450005515000124e+143T

% of Float Held

—

QoQ Change in Holders

+14 / -8

Price History

$0.88$1.99$3.11$4.22$5.34Sep 24Jun 25Mar 26

PYXS — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Atle Fund Management ABNew Position+617K+$709.0M
UNIVERSITY OF CHICAGONew Position+49K+$56.0M
Avanza Fonder ABNew Position+27K+$31.0M
Maia Wealth LLCNew Position+22K+$29.0M
PACES FERRY WEALTH ADVISORS, LLCNew Position+11K+$13.0M
GordonMD Global Investments LPNew Position+4.1M+$4.7M
NISA INVESTMENT ADVISORS, LLCNew Position+961+$1.0M
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COIncreased+7K+$120K
Mirae Asset Global Investments Co., Ltd.New Position+3K+$3K
Physician Wealth Advisors, Inc.New Position+943+$1K
OMERS ADMINISTRATION CorpNew Position+67K+$0
FEDERATED HERMES, INC.New Position+2K+$0
BALYASNY ASSET MANAGEMENT L.P.New Position+8K+$0
Graham Capital Management, L.P.New Position+184K+$0
MARSHALL WACE, LLPNew Position+390K+$0

PYXS — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
TANG CAPITAL MANAGEMENT LLCClosed Position-2.5M-$5.5B
PERCEPTIVE ADVISORS LLCClosed Position-1.2M-$2.6B
MILLENNIUM MANAGEMENT LLCDecreased-72K-$1.8B
STEMPOINT CAPITAL LPClosed Position-690K-$1.5B
DRIEHAUS CAPITAL MANAGEMENT LLCClosed Position-419K-$929.4M
CITADEL ADVISORS LLCDecreased-94K-$748.9M
SCHULHOFF & CO INCClosed Position-275K-$610.5M
DIADEMA PARTNERS LPClosed Position-150K-$333.0M
SUSQUEHANNA INTERNATIONAL GROUP, LLPDecreased-29K-$305.3M
GOLDMAN SACHS GROUP INCDecreased-39K-$278.5M
Walleye Capital LLCClosed Position-120K-$265.4M
ROYAL BANK OF CANADADecreased-22K-$173.0M
BRIDGEWAY CAPITAL MANAGEMENT, LLCDecreased-4K-$170.3M
JACOBS LEVY EQUITY MANAGEMENT, INCClosed Position-60K-$133.9M
TWO SIGMA ADVISERS, LPDecreased-30K-$116.6M

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1PFIZER INC5,952,263$6.8B2.89%Share
2Laurion Capital Management LP4,796,479$5.5B0.17%Share
3PFIZER INC1,080,507$1.2B0.53%Share
4683 Capital Management, LLC891,910$1.0B0.04%Share
5Atle Fund Management AB617,245$709.0M0.23%Share
6Longaeva Partners L.P.503,214$578.0M0.05%Share
7UBS Group AG381,655$438.0M0.07%Share
8Decheng Capital LLC326,810$375.0M0.05%Share
9GROUP ONE TRADING LLC168,200$193.0M0.34%Call
10Cable Car Capital, LP61,606$70.0M0.00%Share
11UNIVERSITY OF CHICAGO48,731$56.0M0.03%Share
12Velan Capital Investment Management LP40,000$46.0M0.03%Share
13Avanza Fonder AB27,345$31.0M0.00%Share
14Maia Wealth LLC21,959$29.0M0.00%Share
15PACES FERRY WEALTH ADVISORS, LLC11,440$13.0M0.01%Share
16GROUP ONE TRADING LLC9,500$10.0M0.02%Put
17UBS Group AG8,311$9.0M0.00%Share
18GordonMD Global Investments LP4,121,870$4.7M3.40%Share
19UBS Group AG2,800$3.0M0.00%Share
20VANGUARD GROUP INC2,013,629$2.0M0.03%Share
21Palo Alto Investors LP1,037,421$1.2M0.17%Share
22NISA INVESTMENT ADVISORS, LLC961$1.0M0.00%Share
23GF FUND MANAGEMENT CO. LTD.1,277$1.0M0.02%Share
24NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO6,575$147K0.00%Share
25NewEdge Wealth, LLC116,006$133K0.00%Share
26China Universal Asset Management Co., Ltd.10,146$11K0.00%Share
27Winthrop Capital Management, LLC6,000$7K0.00%Share
28Mirae Asset Global Investments Co., Ltd.3,026$3K0.00%Share
29Physician Wealth Advisors, Inc.943$1K0.00%Share
30MORGAN STANLEY32,433$00.00%Share
31MORGAN STANLEY56,439$00.00%Share
32BlackRock, Inc.405$00.00%Share
33BlackRock, Inc.8,963$00.00%Share
34BlackRock, Inc.463,651$00.00%Share
35BlackRock, Inc.270,201$00.00%Share
36BlackRock, Inc.40,358$00.00%Share
37BlackRock, Inc.499$00.00%Share
38Cornerstone Financial Management LLC172$00.00%Share
39FOX RUN MANAGEMENT, L.L.C.22,566$00.00%Share
40US BANCORP \DE\94$00.00%Share
41OSAIC HOLDINGS, INC.17,224$00.00%Share
42XTX Topco Ltd289,033$00.00%Share
43WELLS FARGO & COMPANY/MN2,285$00.00%Share
44AMERICAN CENTURY COMPANIES INC31,936$00.00%Share
45BARCLAYS PLC535$00.00%Share
46BARCLAYS PLC53,864$00.00%Share
47BARCLAYS PLC5,986$00.00%Share
48ROYAL BANK OF CANADA55,551$00.00%Share
49BRIDGEWAY CAPITAL MANAGEMENT, LLC72,700$00.00%Share
50TWO SIGMA INVESTMENTS, LP105,528$00.00%Share

PYXS Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 202578$17.0B+15
Q3 202563$48.9B+1
Q2 202562$24.2B-25
Q1 202587$25.5B-11
Q4 202498$35.5B+14
Q3 202484$17.8T+11
Q2 202473$16.8T+12
Q1 202461$317.3T—

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As of Q4 2025, 50 institutional investors hold PYXS (Pyxis Oncology, Inc.). The largest holder is PFIZER INC with $6.8B in shares. This quarter, 14 institutions opened new positions and 8 closed their positions.

Frequently Asked Questions

How many hedge funds own PYXS?

As of Q4 2025, 50 institutional investors report holding PYXS (Pyxis Oncology, Inc.) in their 13F filings.

Who is the largest institutional holder of PYXS?

The largest institutional holder of PYXS is PFIZER INC with $6.8B in shares.

Is institutional ownership of PYXS increasing or decreasing?

This quarter, 14 institutions opened new positions in PYXS and 8 closed their positions.