Palo Alto Investors LP

CIK: 0001306923SEC EDGAR →

Portfolio Value

$718.4M

Holdings

49

As of

Q4 2025

New Positions

3

Closed Positions

4

Portfolio Value History

Top 10 Holdings

RankStockSharesValue% of Portfolio
1

INSMED INC

489,482$85.2M
11.86%
2

AMICUS THERAPEUTICS INC

5,205,767$74.1M
10.32%
3

PTC THERAPEUTICS INC

903,916$68.7M
9.56%
4

ACADIA PHARMACEUTICALS INC

2,484,031$66.3M
9.24%
5

BIOMARIN PHARMACEUTICAL INC

746,256$44.3M
6.17%
6

ANAPTYSBIO INC

690,032$33.5M
4.66%
7

BIOGEN INC

183,571$32.3M
4.50%
8

DYNE THERAPEUTICS INC

1,472,197$28.8M
4.01%
9

UNITED THERAPEUTICS CORP

58,186$28.4M
3.95%
10

DISC MEDICINE INC

317,456$25.2M
3.51%

Quarterly Changes

Top Buys

PTCT↑ Increased
$15.7M
ACAD↑ Increased
$13.7M
CMPXNEW
$13.6M
ANAB↑ Increased
$12.8M
DYN↑ Increased
$12.8M

Top Sells

AM6↓ Decreased
$31.8M
ALNYCLOSED
$14.7M
IM8N↓ Decreased
$14.4M
BIIB↓ Decreased
$6.3M
AGIO↓ Decreased
$4.9M

New Positions (8)

$13.6M · 2.5M shares
$12.0M · 2.4M shares
$6.5M · 226K shares
$5.0M · 299K shares
$4.3M · 97K shares
$809K · 9K shares
$797K · 116K shares
$85K · 15K shares

Closed Positions (3)

$14.7M · 32K shares
$4.8M · 110K shares
$92K · 15K shares

Sector Breakdown

Sector# HoldingsValue%
Healthcare44$517.1M72.0%
Unknown4$194.2M27.0%
Financial Services1$7.0M1.0%