Who Owns Sionna Therapeutics, Inc. (SION)?Hedge Fund & Institutional Holders

$37.13+0.46 (+1.24%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$4.074932774871465e+218T

% of Float Held

3.955172183163214e+289%

QoQ Change in Holders

+14 / -2

Price History

$7.66$16.86$26.07$35.27$44.48Feb 25Aug 25Mar 26

SION — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
JENNISON ASSOCIATES LLCNew Position+1.1M+$45.9M
EVENTIDE ASSET MANAGEMENT, LLCNew Position+639K+$26.3M
PRICE T ROWE ASSOCIATES INC /MD/Increased+194K+$14.2M
Kalehua Capital Management LLCNew Position+197K+$8.1M
SUPERSTRING CAPITAL MANAGEMENT LPNew Position+181K+$7.4M
Artia Global Partners LPNew Position+120K+$4.9M
Invesco Ltd.New Position+111K+$4.6M
Ensign Peak Advisors, IncNew Position+80K+$3.0M
SEVEN GRAND MANAGERS, LLCNew Position+50K+$2.1M
ALPS ADVISORS INCNew Position+37K+$1.0M
Rafferty Asset Management, LLCNew Position+25K+$1.0M
Bank of New York Mellon CorpNew Position+35K+$1.0M
SG Americas Securities, LLCNew Position+11K+$440K
KENNEDY CAPITAL MANAGEMENT LLCNew Position+7K+$277K
AlphaCentric Advisors LLCNew Position+3K+$111K

SION — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
RA CAPITAL MANAGEMENT, L.P.Decreased-540K-$306.8B
ORBIMED ADVISORS LLCDecreased-143K-$108.8B
Atlas Venture Life Science Advisors, LLCDecreased-620K-$106.2B
JPMORGAN CHASE & CODecreased-747K-$58.1B
Aberdeen Group plcDecreased-111K-$27.9B
Soleus Capital Management, L.P.Decreased-145K-$12.1B
Siren, L.L.C.Decreased-25K-$9.5B
BRAIDWELL LPClosed Position-314K-$9.2B
FRANKLIN RESOURCES INCDecreased-67K-$7.1B
MILLENNIUM MANAGEMENT LLCDecreased-134K-$6.3B
Alyeska Investment Group, L.P.Decreased-50K-$5.5B
AMERIPRISE FINANCIAL INCDecreased-52K-$4.5B
SILVERARC CAPITAL MANAGEMENT, LLCDecreased-67K-$3.2B
Holocene Advisors, LPClosed Position-50K-$1.5B
WELLINGTON MANAGEMENT GROUP LLPDecreased-4K-$1.2B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1RA CAPITAL MANAGEMENT, L.P.9,905,045$407.5M4.17%Share
2TPG GP A, LLC6,744,962$277.5M10.33%Share
3ORBIMED ADVISORS LLC3,561,655$146.5M2.99%Share
4VIKING GLOBAL INVESTORS LP3,195,181$131.4M0.35%Share
5Atlas Venture Life Science Advisors, LLC2,995,602$123.2M14.24%Share
6Enavate Sciences GP, LLC2,478,030$101.9M20.12%Share
7PERCEPTIVE ADVISORS LLC1,179,098$48.5M0.86%Share
8JENNISON ASSOCIATES LLC1,115,278$45.9M0.03%Share
9VANGUARD GROUP INC1,070,817$44.1M0.00%Share
10CITADEL ADVISORS LLC1,087,325$44.0M0.01%Share
11JPMORGAN CHASE & CO1,025,078$42.0M0.00%Share
12DEERFIELD MANAGEMENT COMPANY, L.P.970,590$39.9M0.51%Share
13Aberdeen Group plc839,960$34.6M0.05%Share
14PRICE T ROWE ASSOCIATES INC /MD/818,250$33.0M0.00%Share
15BlackRock, Inc.783,071$32.0M0.00%Share
16STATE STREET CORP693,395$28.0M0.00%Share
17EVENTIDE ASSET MANAGEMENT, LLC639,045$26.3M0.41%Share
18BAKER BROS. ADVISORS LP400,000$16.5M0.10%Share
19BlackRock, Inc.385,422$15.0M0.00%Share
20GEODE CAPITAL MANAGEMENT, LLC332,079$13.0M0.00%Share
21Siren, L.L.C.300,000$12.3M0.37%Share
22Soleus Capital Management, L.P.268,500$11.0M0.41%Share
23Kalehua Capital Management LLC197,072$8.1M8.02%Share
24SUPERSTRING CAPITAL MANAGEMENT LP180,593$7.4M3.98%Share
25FRANKLIN RESOURCES INC175,483$7.0M0.00%Share
26JPMORGAN CHASE & CO167,619$6.0M0.00%Share
27CHARLES SCHWAB INVESTMENT MANAGEMENT INC123,686$5.0M0.00%Share
28Alyeska Investment Group, L.P.136,222$5.0M0.01%Share
29Artia Global Partners LP119,741$4.9M0.70%Share
30VANGUARD GROUP INC108,395$4.5M0.00%Share
31Invesco Ltd.104,268$4.3M0.00%Share
32Rock Springs Capital Management LP99,429$4.1M0.21%Share
33TD ASSET MANAGEMENT INC113,352$4.0M0.00%Share
34NORTHERN TRUST CORP109,600$4.0M0.00%Share
35AMERIPRISE FINANCIAL INC101,643$4.0M0.00%Share
36UBS Group AG88,446$3.6M0.00%Share
37DRIEHAUS CAPITAL MANAGEMENT LLC83,850$3.4M0.02%Share
38Longaeva Partners L.P.79,729$3.3M0.28%Share
39Ensign Peak Advisors, Inc79,862$3.0M0.01%Share
40MILLENNIUM MANAGEMENT LLC80,546$3.0M0.00%Share
41SEVEN GRAND MANAGERS, LLC50,000$2.1M0.16%Share
42MANUFACTURERS LIFE INSURANCE COMPANY, THE69,424$2.0M0.00%Share
43SILVERARC CAPITAL MANAGEMENT, LLC41,460$1.7M0.24%Share
44POLEN CAPITAL MANAGEMENT LLC31,258$1.3M0.01%Share
45WELLINGTON MANAGEMENT GROUP LLP25,696$1.0M0.00%Share
46BlackRock, Inc.29,771$1.0M0.00%Share
47BlackRock, Inc.32,877$1.0M0.00%Share
48BlackRock, Inc.46,709$1.0M0.00%Share
49MORGAN STANLEY25,549$1.0M0.00%Share
50BARCLAYS PLC48,172$1.0M0.00%Share

SION Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025100$1.8B+28
Q3 202572$1.2T+19
Q2 202553$720.1B+6
Q1 202547$423.6B—

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As of Q4 2025, 50 institutional investors hold SION (Sionna Therapeutics, Inc.). The largest holder is RA CAPITAL MANAGEMENT, L.P. with $407.5M in shares. This quarter, 14 institutions opened new positions and 2 closed their positions.

Frequently Asked Questions

How many hedge funds own SION?

As of Q4 2025, 50 institutional investors report holding SION (Sionna Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of SION?

The largest institutional holder of SION is RA CAPITAL MANAGEMENT, L.P. with $407.5M in shares.

Is institutional ownership of SION increasing or decreasing?

This quarter, 14 institutions opened new positions in SION and 2 closed their positions.