| 1 | Column Group LLC | 9,400,290 | $6.7M | 8.08% | Share |
| 2 | VANGUARD GROUP INC | 7,813,944 | $5.6M | 0.00% | Share |
| 3 | Empery Asset Management, LP | 5,414,101 | $3.9M | 3.40% | Share |
| 4 | MILLENNIUM MANAGEMENT LLC | 4,615,746 | $3.0M | 0.00% | Share |
| 5 | Anson Funds Management LP | 4,152,966 | $3.0M | 0.28% | Share |
| 6 | CITADEL ADVISORS LLC | 4,200,000 | $2.0M | 0.00% | Share |
| 7 | Alyeska Investment Group, L.P. | 4,000,000 | $2.0M | 0.01% | Share |
| 8 | Kalehua Capital Management LLC | 2,000,000 | $1.4M | 1.41% | Share |
| 9 | Burkehill Global Management, LP | 2,000,000 | $1.4M | 0.09% | Share |
| 10 | ADAR1 Capital Management, LLC | 1,505,300 | $1.1M | 0.08% | Share |
| 11 | SPHERA FUNDS MANAGEMENT LTD. | 1,500,000 | $1.1M | 0.21% | Share |
| 12 | BlackRock, Inc. | 2,327,201 | $1.0M | 0.00% | Share |
| 13 | BlackRock, Inc. | 1,437,870 | $1.0M | 0.00% | Share |
| 14 | RENAISSANCE TECHNOLOGIES LLC | 1,850,867 | $1.0M | 0.00% | Share |
| 15 | GSA CAPITAL PARTNERS LLP | 1,478,612 | $1.0M | 0.09% | Share |
| 16 | Euclidean Capital LLC | 1,015,705 | $722K | 0.20% | Share |
| 17 | Alphabet Inc. | 915,705 | $650K | 0.03% | Share |
| 18 | VANGUARD GROUP INC | 696,094 | $495K | 0.00% | Share |
| 19 | Mirador Capital Partners LP | 582,524 | $414K | 0.06% | Share |
| 20 | UBS Group AG | 574,601 | $409K | 0.00% | Share |
| 21 | StepStone Group LP | 462,163 | $328K | 0.18% | Share |
| 22 | Casdin Capital, LLC | 361,969 | $257K | 0.02% | Share |
| 23 | Stonepine Capital Management, LLC | 352,001 | $250K | 0.18% | Share |
| 24 | GROUP ONE TRADING LLC | 281,900 | $200K | 0.00% | Call |
| 25 | Corient Private Wealth LLC | 100,800 | $71K | 0.00% | Share |
| 26 | VANGUARD GROUP INC | 50,070 | $35K | 0.00% | Share |
| 27 | ATTICUS WEALTH MANAGEMENT, LLC | 43,237 | $30K | 0.01% | Share |
| 28 | Virtu Financial LLC | 32,725 | $23K | 0.00% | Share |
| 29 | EWA, LLC | 31,422 | $22K | 0.01% | Share |
| 30 | China Universal Asset Management Co., Ltd. | 27,132 | $19K | 0.00% | Share |
| 31 | KESTRA PRIVATE WEALTH SERVICES, LLC | 22,000 | $15K | 0.00% | Share |
| 32 | World Investment Advisors | 18,787 | $13K | 0.00% | Share |
| 33 | CITIZENS FINANCIAL GROUP INC/RI | 18,000 | $12K | 0.00% | Share |
| 34 | Parkwoods Wealth Partners, LLC | 17,000 | $12K | 0.00% | Share |
| 35 | Legacy Wealth Partners, LLC | 14,084 | $10K | 0.00% | Share |
| 36 | Jasper Ridge Partners, L.P. | 10,250 | $7K | 0.00% | Share |
| 37 | Quadcap Wealth Management, LLC | 10,000 | $7K | 0.00% | Share |
| 38 | Galvin, Gaustad & Stein, LLC | 11,000 | $7K | 0.00% | Share |
| 39 | Sequoia Financial Advisors, LLC | 10,725 | $7K | 0.00% | Share |
| 40 | GROUP ONE TRADING LLC | 9,508 | $6K | 0.00% | Share |
| 41 | Mirae Asset Global Investments Co., Ltd. | 8,091 | $5K | 0.00% | Share |
| 42 | GROUP ONE TRADING LLC | 5,200 | $3K | 0.00% | Put |
| 43 | VSM Wealth Advisory, LLC | 5,000 | $3K | 0.00% | Share |
| 44 | UBS Group AG | 5,000 | $3K | 0.00% | Share |
| 45 | Torren Management, LLC | 3,673 | $2K | 0.00% | Share |
| 46 | NISA INVESTMENT ADVISORS, LLC | 2,252 | $1K | 0.00% | Share |
| 47 | CWM, LLC | 1,559 | $1K | 0.00% | Share |
| 48 | EverSource Wealth Advisors, LLC | 1,541 | $1K | 0.00% | Share |
| 49 | TFC Financial Management, Inc. | 2,500 | $1K | 0.00% | Share |
| 50 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 194,800 | $0 | 0.00% | Share |