Who Owns Tyra Biosciences, Inc. (TYRA)?Hedge Fund & Institutional Holders

$35.87-0.13 (-0.36%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$3.2070110662810054e+217T

% of Float Held

3.3162257711429855e+298%

QoQ Change in Holders

+15 / -3

Price History

$7.06$14.43$21.80$29.17$36.54Sep 24Jun 25Mar 26

TYRA — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
Canaan Partners XI LLCNew Position+3.4M+$88.7M
Trails Edge Capital Partners, LPNew Position+700K+$18.4M
BOONE CAPITAL MANAGEMENT LLCNew Position+398K+$10.5M
Elmind Capital, LPNew Position+350K+$9.2M
Logos Global Management LPNew Position+210K+$5.5M
Soleus Capital Management, L.P.New Position+125K+$3.3M
BNP Paribas Asset Management Holding S.A.New Position+130K+$3.0M
OPPENHEIMER & CO INCNew Position+85K+$2.2M
Kalehua Capital Management LLCNew Position+74K+$2.0M
SUPERSTRING CAPITAL MANAGEMENT LPNew Position+59K+$1.5M
ALGERT GLOBAL LLCNew Position+47K+$1.0M
ALPS ADVISORS INCNew Position+44K+$1.0M
Bank of New York Mellon CorpNew Position+61K+$1.0M
SUSQUEHANNA INTERNATIONAL GROUP, LLPNew Position+55K+$1.0M
ExodusPoint Capital Management, LPNew Position+43K+$1.0M

TYRA — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Alta Partners Management Company, L.P.Decreased-257K-$57.0B
BVF INC/ILDecreased-1.5M-$51.0B
Kynam Capital Management, LPDecreased-766K-$32.6B
BALYASNY ASSET MANAGEMENT L.P.Decreased-28K-$11.8B
MORGAN STANLEYDecreased-203K-$4.5B
Walleye Capital LLCClosed Position-298K-$4.2B
JACOBS LEVY EQUITY MANAGEMENT, INCDecreased-122K-$3.5B
NORTHERN TRUST CORPDecreased-8K-$2.9B
CHARLES SCHWAB INVESTMENT MANAGEMENT INCDecreased-2K-$2.8B
TWO SIGMA INVESTMENTS, LPDecreased-92K-$2.8B
RENAISSANCE TECHNOLOGIES LLCClosed Position-170K-$2.4B
MILLENNIUM MANAGEMENT LLCDecreased-30K-$2.0B
BANK OF AMERICA CORP /DE/Decreased-96K-$1.9B
AXA Investment Managers S.A.Closed Position-129K-$1.8B
BNP PARIBAS FINANCIAL MARKETSDecreased-9K-$1.8B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1RA CAPITAL MANAGEMENT, L.P.12,198,625$320.7M3.29%Share
2Nextech Invest, Ltd.4,055,861$106.6M10.31%Share
3Alta Partners Management Company, L.P.3,823,425$100.5M97.03%Share
4Commodore Capital LP3,375,000$88.7M5.91%Share
5Canaan Partners XI LLC3,374,329$88.7M64.85%Share
6JANUS HENDERSON GROUP PLC2,935,442$77.0M0.03%Share
7TCG Crossover Management, LLC2,898,103$76.2M2.52%Share
8Vestal Point Capital, LP2,425,000$63.8M2.17%Share
9BVF INC/IL2,127,665$55.9M1.88%Share
10FARALLON CAPITAL MANAGEMENT LLC2,066,818$54.3M0.26%Share
11Kynam Capital Management, LP1,564,492$41.1M2.63%Share
12VANGUARD GROUP INC1,405,024$36.9M0.00%Share
13BlackRock, Inc.1,245,917$32.0M0.00%Share
145AM Venture Management, LLC1,029,298$27.1M8.51%Share
15Caligan Partners LP944,257$24.8M2.04%Share
16Point72 Asset Management, L.P.874,192$22.0M0.02%Share
17BALYASNY ASSET MANAGEMENT L.P.818,326$21.0M0.03%Share
18STATE STREET CORP749,463$19.0M0.00%Share
19Trails Edge Capital Partners, LP700,000$18.4M4.55%Share
20MARSHALL WACE, LLP708,417$18.0M0.02%Share
21GEODE CAPITAL MANAGEMENT, LLC574,972$15.0M0.00%Share
22BlackRock, Inc.602,651$15.0M0.00%Share
23Sio Capital Management, LLC526,002$13.8M2.18%Share
24BOONE CAPITAL MANAGEMENT LLC398,482$10.5M3.29%Share
25Elmind Capital, LP350,000$9.2M2.72%Share
26Eversept Partners, LP278,564$7.3M0.37%Share
27Logos Global Management LP210,000$5.5M0.33%Share
28CHARLES SCHWAB INVESTMENT MANAGEMENT INC199,426$5.0M0.00%Share
29BOOTHBAY FUND MANAGEMENT, LLC221,177$5.0M0.07%Share
30VANGUARD GROUP INC154,564$4.1M0.00%Share
31GOLDMAN SACHS GROUP INC182,387$4.0M0.00%Share
32NORTHERN TRUST CORP188,835$4.0M0.00%Share
33Soleus Capital Management, L.P.125,000$3.3M0.12%Share
34Invesco Ltd.115,906$3.0M0.00%Share
35RAYMOND JAMES FINANCIAL INC123,016$3.0M0.00%Share
36BNP Paribas Asset Management Holding S.A.129,779$3.0M0.00%Share
37MILLENNIUM MANAGEMENT LLC114,388$3.0M0.00%Share
38BNP PARIBAS FINANCIAL MARKETS120,278$3.0M0.00%Share
39JACOBS LEVY EQUITY MANAGEMENT, INC129,753$3.0M0.01%Share
40INVESTMENT COUNSEL CO OF NEVADA85,020$2.2M4.80%Share
41OPPENHEIMER & CO INC84,726$2.2M0.03%Share
42BlackRock, Inc.83,384$2.0M0.00%Share
43GEODE CAPITAL MANAGEMENT, LLC82,784$2.0M0.00%Share
44DIMENSIONAL FUND ADVISORS LP86,941$2.0M0.00%Share
45TWO SIGMA INVESTMENTS, LP107,023$2.0M0.00%Share
46BARCLAYS PLC76,299$2.0M0.00%Share
47Kalehua Capital Management LLC74,465$2.0M1.94%Share
48SUPERSTRING CAPITAL MANAGEMENT LP58,677$1.5M0.83%Share
49UBS Group AG49,347$1.3M0.00%Share
50PDT Partners, LLC42,284$1.1M0.07%Share

TYRA Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025132$1.5B+35
Q3 202597$724.4B+0
Q2 202597$493.1B-21
Q1 2025118$498.6B+8
Q4 2024110$732.0B+31
Q3 202479$661.7T+12
Q2 202467$400.3T+0
Q1 202467$426.5T—

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As of Q4 2025, 50 institutional investors hold TYRA (Tyra Biosciences, Inc.). The largest holder is RA CAPITAL MANAGEMENT, L.P. with $320.7M in shares. This quarter, 15 institutions opened new positions and 3 closed their positions.

Frequently Asked Questions

How many hedge funds own TYRA?

As of Q4 2025, 50 institutional investors report holding TYRA (Tyra Biosciences, Inc.) in their 13F filings.

Who is the largest institutional holder of TYRA?

The largest institutional holder of TYRA is RA CAPITAL MANAGEMENT, L.P. with $320.7M in shares.

Is institutional ownership of TYRA increasing or decreasing?

This quarter, 15 institutions opened new positions in TYRA and 3 closed their positions.