| 1 | Corvex Management LP | 3,058,629 | $397.8M | 12.16% | Share |
| 2 | Casdin Capital, LLC | 3,007,164 | $391.1M | 24.29% | Share |
| 3 | VANGUARD GROUP INC | 1,017,287 | $132.3M | 0.00% | Share |
| 4 | WESTFIELD CAPITAL MANAGEMENT CO LP | 1,018,261 | $132.0M | 0.55% | Share |
| 5 | GOLDMAN SACHS GROUP INC | 1,019,659 | $132.0M | 0.02% | Share |
| 6 | SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 920,587 | $119.7M | 2.49% | Share |
| 7 | ORACLE INVESTMENT MANAGEMENT INC | 884,654 | $115.1M | 68.51% | Share |
| 8 | WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 809,210 | $105.2M | 0.29% | Share |
| 9 | FMR LLC | 805,393 | $104.0M | 0.01% | Share |
| 10 | Invesco Ltd. | 767,583 | $99.8M | 0.02% | Share |
| 11 | BlackRock, Inc. | 738,091 | $95.0M | 0.00% | Share |
| 12 | FRANKLIN RESOURCES INC | 699,040 | $90.0M | 0.02% | Share |
| 13 | ARK Investment Management LLC | 604,561 | $78.6M | 0.52% | Share |
| 14 | BlackRock, Inc. | 604,460 | $78.0M | 0.00% | Share |
| 15 | Zweig-DiMenna Associates LLC | 597,825 | $77.0M | 4.78% | Share |
| 16 | LORD, ABBETT & CO. LLC | 504,920 | $65.0M | 0.20% | Share |
| 17 | STATE STREET CORP | 456,258 | $59.0M | 0.00% | Share |
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 438,229 | $57.0M | 0.00% | Share |
| 19 | DRIEHAUS CAPITAL MANAGEMENT LLC | 395,323 | $51.4M | 0.35% | Share |
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 395,248 | $51.0M | 0.01% | Share |
| 21 | Sumitomo Mitsui Trust Group, Inc. | 381,725 | $49.6M | 0.03% | Share |
| 22 | Amova Asset Management Americas, Inc. | 381,725 | $49.6M | 0.57% | Share |
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 381,200 | $49.0M | 0.01% | Put |
| 24 | MORGAN STANLEY | 351,836 | $45.0M | 0.00% | Share |
| 25 | RAYMOND JAMES FINANCIAL INC | 352,058 | $45.0M | 0.01% | Share |
| 26 | WELLINGTON MANAGEMENT GROUP LLP | 349,844 | $45.0M | 0.01% | Share |
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 340,300 | $44.0M | 0.01% | Call |
| 28 | FRANKLIN RESOURCES INC | 278,514 | $36.0M | 0.01% | Share |
| 29 | Capital International Investors | 283,248 | $36.0M | 0.01% | Share |
| 30 | FRED ALGER MANAGEMENT, LLC | 266,636 | $34.0M | 0.13% | Share |
| 31 | JENNISON ASSOCIATES LLC | 257,916 | $33.5M | 0.02% | Share |
| 32 | GAGNON SECURITIES LLC | 253,534 | $33.0M | 6.71% | Share |
| 33 | ALLIANCEBERNSTEIN L.P. | 253,454 | $32.0M | 0.01% | Share |
| 34 | NOMURA ASSET MANAGEMENT INTERNATIONAL INC. | 227,284 | $29.0M | 0.04% | Share |
| 35 | Assenagon Asset Management S.A. | 205,895 | $26.8M | 0.04% | Share |
| 36 | Science & Technology Partners, L.P. | 201,264 | $26.2M | 7.28% | Share |
| 37 | OBERWEIS ASSET MANAGEMENT INC/ | 198,770 | $25.9M | 0.95% | Share |
| 38 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 193,238 | $25.1M | 0.01% | Share |
| 39 | GOLDMAN SACHS GROUP INC | 198,483 | $25.0M | 0.00% | Share |
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,030 | $23.0M | 0.00% | Share |
| 41 | NEXT CENTURY GROWTH INVESTORS LLC | 173,411 | $22.6M | 1.57% | Share |
| 42 | Alamea Verwaltungs GmbH | 185,989 | $21.1M | 14.25% | Share |
| 43 | CITADEL ADVISORS LLC | 155,545 | $20.0M | 0.00% | Share |
| 44 | NORTHERN TRUST CORP | 154,219 | $20.0M | 0.00% | Share |
| 45 | VANGUARD GROUP INC | 142,570 | $18.5M | 0.00% | Share |
| 46 | T. Rowe Price Investment Management, Inc. | 136,488 | $17.8M | 0.02% | Share |
| 47 | ASHFORD CAPITAL MANAGEMENT INC | 132,326 | $17.2M | 1.92% | Share |
| 48 | Gagnon Advisors, LLC | 127,062 | $16.5M | 10.49% | Share |
| 49 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 130,658 | $16.0M | 0.00% | Share |
| 50 | Capital Research Global Investors | 122,666 | $15.0M | 0.00% | Share |