Who Owns Xenon Pharmaceuticals Inc. (XENE)?Hedge Fund & Institutional Holders

$54.84-0.39 (-0.71%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+4 / -7

Price History

$28.23$36.86$45.50$54.13$62.76Sep 24Jun 25Mar 26

XENE — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+1K+$397.6B
WELLINGTON MANAGEMENT GROUP LLPIncreased+1.2M+$66.1B
JENNISON ASSOCIATES LLCNew Position+1.3M+$57.9B
DRIEHAUS CAPITAL MANAGEMENT LLCIncreased+370K+$36.0B
FEDERATED HERMES, INC.New Position+672K+$30.0B
Avoro Capital Advisors LLCIncreased+24K+$26.3B
JANUS HENDERSON GROUP PLCIncreased+140K+$23.7B
BARCLAYS PLCIncreased+490K+$21.5B
CITADEL ADVISORS LLCIncreased+362K+$19.5B
TWO SIGMA INVESTMENTS, LPNew Position+437K+$19.0B
Aberdeen Group plcIncreased+171K+$10.4B
Eversept Partners, LPNew Position+231K+$10.4B
TWO SIGMA ADVISERS, LPIncreased+241K+$10.3B
Fiera Capital CorpIncreased+166K+$9.1B
BANK OF AMERICA CORP /DE/Increased+22K+$9.0B

XENE — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Commodore Capital LPDecreased-900K-$27.7B
MILLENNIUM MANAGEMENT LLCDecreased-749K-$27.6B
MARSHALL WACE, LLPDecreased-449K-$24.6B
Holocene Advisors, LPDecreased-694K-$22.4B
Saturn V Capital Management LPClosed Position-504K-$20.2B
Vestal Point Capital, LPDecreased-500K-$17.3B
Tri Locum Partners LPClosed Position-366K-$14.7B
BALYASNY ASSET MANAGEMENT L.P.Decreased-238K-$9.9B
GREAT POINT PARTNERS LLCClosed Position-200K-$8.0B
AXA Investment Managers S.A.Closed Position-176K-$7.1B
JANE STREET GROUP, LLCClosed Position-90K-$3.6B
ADAGE CAPITAL PARTNERS GP, L.L.C.Decreased-150K-$3.5B
HighVista Strategies LLCClosed Position-82K-$3.3B
Jain Global LLCDecreased-78K-$3.1B
Avidity Partners Management LPClosed Position-53K-$2.1B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1FMR LLC6,201,846$277.0B14.12%Share
2Avoro Capital Advisors LLC5,424,444$243.1B2389.56%Share
3DRIEHAUS CAPITAL MANAGEMENT LLC4,538,691$203.4B1381.77%Share
4WELLINGTON MANAGEMENT GROUP LLP4,262,180$191.0B33.47%Share
5JANUS HENDERSON GROUP PLC4,047,208$181.0B81.06%Share
6Polar Capital Holdings Plc2,465,694$110.0B425.09%Share
7FMR LLC2,144,706$96.0B4.89%Share
8Commodore Capital LP1,800,000$80.7B5.37%Share
9ALLIANCEBERNSTEIN L.P.1,593,814$71.0B22.42%Share
10CITADEL ADVISORS LLC1,313,847$58.0B8.71%Share
11JENNISON ASSOCIATES LLC1,292,055$57.9B34.77%Share
12Holocene Advisors, LP1,282,081$57.0B119.70%Share
13Affinity Asset Advisors, LLC1,250,000$56.0B3.19%Share
14WESTFIELD CAPITAL MANAGEMENT CO LP1,226,771$54.0B224.95%Share
15JPMORGAN CHASE & CO882,520$39.0B2.45%Share
16Siren, L.L.C.812,761$36.4B1.09%Share
17First Turn Management, LLC799,743$35.8B4.10%Share
18Rock Springs Capital Management LP787,788$35.3B1.81%Share
19Aberdeen Group plc750,291$33.6B52.06%Share
20FEDERATED HERMES, INC.672,237$30.0B50.12%Share
21ADAGE CAPITAL PARTNERS GP, L.L.C.685,100$30.0B45.40%Share
22AMERICAN CENTURY COMPANIES INC680,473$30.0B15.08%Share
23Capital World Investors655,737$29.0B3.94%Share
24MILLENNIUM MANAGEMENT LLC635,056$28.0B11.78%Share
25Vestal Point Capital, LP600,000$26.9B0.91%Share
26FMR LLC573,698$25.0B1.27%Share
27Caligan Partners LP549,700$24.6B2.03%Put
28Caligan Partners LP549,665$24.6B2.03%Share
29DEERFIELD MANAGEMENT COMPANY, L.P.542,020$24.3B310.25%Share
30JPMORGAN CHASE & CO549,055$24.0B1.51%Share
31BARCLAYS PLC542,431$24.0B5.76%Share
32TimesSquare Capital Management, LLC532,740$23.9B359.68%Share
33LOOMIS SAYLES & CO L P499,717$22.0B26.52%Share
34ORBIMED ADVISORS LLC447,200$20.0B0.41%Share
35Fiera Capital Corp447,286$20.0B63.42%Share
36TWO SIGMA INVESTMENTS, LP436,743$19.0B26.80%Share
37Candriam S.C.A.417,402$18.0B89.63%Share
38NORTHERN TRUST CORP390,629$17.0B2.17%Share
39DIMENSIONAL FUND ADVISORS LP384,034$17.0B3.57%Share
40BAKER BROS. ADVISORS LP370,208$16.6B97.15%Share
41GOLDMAN SACHS GROUP INC374,084$16.0B1.97%Share
42WELLINGTON MANAGEMENT GROUP LLP370,968$16.0B2.80%Share
43STEMPOINT CAPITAL LP348,605$15.6B2.68%Share
44FRANKLIN RESOURCES INC326,943$14.0B3.43%Share
45GOLDMAN SACHS GROUP INC311,398$13.0B1.60%Share
46Caption Management, LLC290,000$13.0B89.13%Put
47Caption Management, LLC290,000$13.0B89.13%Call
48FRANKLIN RESOURCES INC266,743$11.0B2.70%Share
49TWO SIGMA ADVISERS, LP259,320$11.0B21.39%Share
50Nicholas Investment Partners, LP242,989$10.9B0.79%Share

XENE Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025246$2.8T+67
Q3 2025179$2.2T+12
Q2 2025167$1.5T-39
Q1 2025206$1.9T+4
Q4 2024202$2.3T+39
Q3 2024163$222.1T-9
Q2 2024172$215.2T-3
Q1 2024175$179.8T—

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As of Q4 2025, 50 institutional investors hold XENE (Xenon Pharmaceuticals Inc.). The largest holder is FMR LLC with $277.0B in shares. This quarter, 4 institutions opened new positions and 7 closed their positions.

Frequently Asked Questions

How many hedge funds own XENE?

As of Q4 2025, 50 institutional investors report holding XENE (Xenon Pharmaceuticals Inc.) in their 13F filings.

Who is the largest institutional holder of XENE?

The largest institutional holder of XENE is FMR LLC with $277.0B in shares.

Is institutional ownership of XENE increasing or decreasing?

This quarter, 4 institutions opened new positions in XENE and 7 closed their positions.