Commodore Capital LP

CIK: 0001831942Latest portfolio: $1.5B · Q4 2025

Holdings

33

Total Value

$1.5B

New Positions

6

Closed Positions

9

#StockSharesValue% PortfolioChangeType
1
RLAYRELAY THERAPEUTICS INC
17,000,000$143.8M9.57%
2
ALKSALKERMES PLC
3,550,000$99.3M6.61%+453K
3
TYRATYRA BIOSCIENCES INC
3,375,000$88.7M5.91%
4
XENEXENON PHARMACEUTICALS INC
1,800,000$80.7M5.37%-900,000
5
SYRESPYRE THERAPEUTICS INC
2,388,245$78.2M5.21%+400K
6
COGTCOGENT BIOSCIENCES INC
2,196,845$78.0M5.19%-5,053,155
7
ELVNENLIVEN THERAPEUTICS INC
4,692,809$72.3M4.81%
8
TCE2CELLDEX THERAPEUTICS INC NEW
2,565,000$69.7M4.64%-463,335
9
AMLXAMYLYX PHARMACEUTICALS INC
5,650,000$68.3M4.54%+1.6M
10
TERNTERNS PHARMACEUTICALS INC
1,475,000$59.6M3.97%-4,225,000
11
KYMRKYMERA THERAPEUTICS INC
750,000$58.4M3.88%
12
SLNOSOLENO THERAPEUTICS INC
1,200,000$55.6M3.70%-150,000
13
NUVLNUVALENT INC
550,000$55.3M3.68%-850,000
14
ORKAORUKA THERAPEUTICS INC
1,753,054$53.1M3.54%
15
PHVSPHARVARIS N V
1,889,445$52.4M3.49%-529,031
16
NRIXNURIX THERAPEUTICS INC
2,275,000$43.2M2.87%-1,505,055
17
PTGXPROTAGONIST THERAPEUTICS INC
450,000$39.3M2.62%-575,000
18
ASMBASSEMBLY BIOSCIENCES INC
1,000,000$34.0M2.26%
19
LBRXLB PHARMACEUTICALS INC
1,500,000$33.4M2.22%
20
CTMXCYTOMX THERAPEUTICS INC
7,692,300$32.8M2.18%
21
ANROALTO NEUROSCIENCE INC
1,823,196$32.5M2.16%NEW
22
PALIPALISADE BIO INC
11,445,000$26.9M1.79%NEW
23
BRD1EURMIND MEDICINE MINDMED INC
2,000,000$26.8M1.78%-1,225,000
24
CNTACENTESSA PHARMACEUTICALS PLC
1,000,000$25.0M1.66%-1,850,000
25
PEPGPEPGEN INC
3,400,000$22.1M1.47%+1.0M

Quarterly Changes

New Positions

Closed Positions

  • MRUSCLOSED
    $331.9B
  • AGIOCLOSED
    $93.9B
  • VRDNCLOSED
    $69.1B
  • CDTXCLOSED
    $56.0B
  • TNGXCLOSED
    $12.6B
  • APGECLOSED
    $11.5B
  • ENTACLOSED
    $9.6B
  • PERCEPTIVE CAP SOLUTIONS CORCLOSED
    $7.9B
  • VTGNCLOSED
    $5.6B
  • CBIOCLOSED
    $5.4B

Increased Positions

NameSharesChange
AMLX5.7M+1.6M
PEPG3.4M+1.0M
ALKS3.5M+453K
SYRE2.4M+400K
PTGX450K+-575000
NUVL550K+-850000

Decreased Positions

NameSharesChange
COGT2.2M-5053155
TERN1.5M-4225000
CNTA1.0M-1850000
NRIX2.3M-1505055
BRD1EUR2.0M-1225000
XENE1.8M-900000
PHVS1.9M-529031
DRUG19K-481149
TCE22.6M-463335
SLNO1.2M-150000

Sector Breakdown

Healthcare0.0% ($1.4382099329887288e+141T)
Unknown0.0% ($7.0T)

Filing History

QuarterFiling DatePortfolio ValueHoldings
Q4 2025Feb 17, 2026$1.5B33
Q3 2025Nov 14, 2025$2.0T37
Q2 2025Aug 14, 2025$1.4T33
Q1 2025May 15, 2025$1.4T31
Q4 2024Feb 14, 2025$1.4T31
Q3 2024Nov 14, 2024$1600.3T36
Q2 2024Aug 14, 2024$1465.0T35
Q1 2024May 15, 2024$1495.5T39
Q4 2023Feb 14, 2024$1155.8T32
Q3 2023Nov 14, 2023$855.5T30
Q2 2023Aug 14, 2023$889.8T26
Q1 2023May 15, 2023$656.8T32
Q4 2022Feb 14, 2023$663.5B35
Q3 2022Nov 14, 2022$621.9B30
Q2 2022Aug 15, 2022$473.0B24
Q1 2022May 16, 2022$447.7B27
Q4 2021Feb 14, 2022$431.8B25
Q3 2021Nov 15, 2021$379.3B29
Q2 2021Aug 16, 2021$290.3B29
Q1 2021May 17, 2021$254.0B31
Q4 2020Feb 16, 2021$183.9B28

Fund Information

CIK0001831942
Most Recent FilingFeb 17, 2026
Number of Filings21

Commodore Capital LP is an institutional investment manager that files 13F reports with the SEC. As of the Q4 2025 filing, the fund reported a portfolio valued at $1.5B across 33 holdings. The largest position is RELAY THERAPEUTICS INC (RLAY), representing 9.6% of the portfolio. Compared to the previous quarter, the fund opened 6 new positions and closed 10 positions. 13F filings are required quarterly disclosures that provide transparency into the holdings of institutional investment managers with at least $100 million in qualifying assets.