BAKER BROS. ADVISORS LP Q3 2019 Filing

Filed November 14, 2019

Portfolio Value

$14.7B

Holdings

109

Report Date

Q3 2019

Filing Type

13F-HR

All Holdings (109 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
50,057,277$4.3T29081.51%
2
INCYIncyte Corporation
31,976,557$2.4T16147.42%
3
ACADACADIA Pharmaceuticals Inc.
40,854,586$1.5T10002.64%
4
ONCBeiGene, Ltd.
11,777,285$1.4T9811.40%
5
ALXNAlexion Pharmaceuticals, Inc.
8,258,068$808.8B5502.12%
6
AMRNAmarin Corporation plc
41,544,288$629.8B4284.52%
7
Genomic Health, Inc.
9,244,665$627.0B4265.21%
8
BMRNBioMarin Pharmaceutical Inc.
7,589,294$511.5B3479.79%
9
ASNDAscendis Pharma A/S
3,390,270$326.6B2221.48%
10
NVTA1EURInvitae Corporation
8,792,678$169.4B1152.64%
11
KODKodiak Sciences Inc.
9,145,116$131.5B894.62%
12
NBIXNeurocrine Biosciences, Inc.
1,415,283$127.5B867.58%
13
ARGXargenx SE
1,019,557$116.2B790.42%
14
HRTXHeron Therapeutics, Inc.
6,018,104$111.3B757.40%
15
MRTXEURMirati Therapeutics, Inc.
1,307,220$101.8B692.84%
16
MDGLMadrigal Pharmaceuticals, Inc.
1,169,278$100.8B685.83%
17
MyoKardia, Inc.
1,517,237$79.1B538.27%
18
Spark Therapeutics, Inc.
751,927$72.9B496.08%
19
1T7Tricida, Inc.
1,969,905$60.8B413.69%
20
RYTMRhythm Pharmaceuticals, Inc.
2,708,200$58.5B397.76%
21
1K0IGM Biosciences, Inc.
3,144,000$55.8B379.64%
22
Ra Pharmaceuticals, Inc.
2,345,496$55.5B377.36%
23
CERSCerus Corporation
10,749,937$55.4B376.99%
24
DBV Technologies S.A.
5,509,560$47.4B322.33%
25
Principia Biopharma Inc.
1,654,029$46.7B317.76%
26
BCELAtreca, Inc.
3,532,760$43.2B294.16%
27
GW Pharmaceuticals plc
370,845$42.7B290.20%
28
Zymeworks Inc.
1,708,472$42.4B288.24%
29
Audentes Therapeutics, Inc.
1,506,438$42.3B287.87%
30
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$42.1B286.49%
31
IM8NInsmed Incorporated
2,229,760$39.3B267.58%
32
BCRXBioCryst Pharmaceuticals, Inc.
12,725,472$36.5B248.02%
33
ADPTAdaptive Biotechnologies Corporation
1,165,411$36.0B244.98%
34
KRYSKrystal Biotech, Inc.
1,034,674$35.9B244.42%
35
Neoleukin Therapeutics, Inc.
11,305,679$32.2B219.20%
36
CBAYUSDCymaBay Therapeutics, Inc.
5,707,411$29.2B198.79%
37
ALLKGUSDAllakos Inc.
339,690$26.7B181.70%
38
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$23.8B162.07%
39
MRUSMerus N.V.
1,160,014$20.7B140.62%
40
QUREuniQure N.V.
517,700$20.4B138.62%
41
URGNUroGen Pharma Ltd.
747,751$17.8B121.22%
42
AXSMAxsome Therapeutics, Inc.
772,286$15.6B106.34%
43
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$14.7B100.15%
44
XNCRXencor, Inc.
428,120$14.4B98.23%
45
Aimmune Therapeutics, Inc.
673,908$14.1B96.00%
46
PTGXProtagonist Therapeutics, Inc.
1,174,282$14.1B95.94%
47
La Jolla Pharmaceutical Company
1,559,231$13.7B93.34%
48
Idera Pharmaceuticals, Inc.
4,608,786$13.3B90.61%
49
AGLEUSDAeglea BioTherapeutics, Inc.
1,713,604$13.2B89.65%
50
ALKSAlkermes plc
625,030$12.2B82.95%
51
Syros Pharmaceuticals, Inc.
974,835$10.1B68.84%
52
GBYSangamo Therapeutics, Inc.
999,823$9.0B61.55%
53
ASMBAssembly Biosciences, Inc.
803,246$7.9B53.72%
54
TPIVDEURMarker Therapeutics, Inc.
1,500,000$7.7B52.14%
55
APLSApellis Pharmaceuticals, Inc.
313,725$7.6B51.42%
56
CPRXCatalyst Pharmaceuticals, Inc.
1,341,902$7.1B48.47%
57
HOOKGBPHOOKIPA Pharma Inc.
892,857$6.7B45.55%
58
Acorda Therapeutics, Inc.
2,232,589$6.4B43.59%
59
Dermira, Inc.
906,943$5.8B39.42%
60
XBITXbiotech Inc.
521,327$5.5B37.10%
61
BDQMAlbireo Pharma, Inc.
250,000$5.0B34.01%
62
VSAREURAravive, Inc.
664,088$5.0B33.89%
63
MISTMilestone Pharmaceuticals Inc.
266,667$5.0B33.83%
64
ORTXUSDOrchard Therapeutics plc
405,702$4.8B32.79%
65
HALOHalozyme Therapeutics, Inc.
299,969$4.7B31.65%
66
NXTCNextCure, Inc.
150,000$4.6B31.48%
67
IFRXInflarx N.V.
1,778,415$4.4B29.88%
68
ANABAnaptysBio, Inc.
113,086$4.0B26.92%
69
Achillion Pharmaceuticals, Inc.
1,095,359$3.9B26.82%
70
GLPGGalapagos NV
25,072$3.8B26.03%
71
bluebird bio, Inc.
40,000$3.7B24.99%
72
NGMUSDNGM Biopharmaceuticals, Inc.
250,000$3.5B23.56%
73
MIRMMirum Pharmaceuticals, Inc.
333,333$3.4B22.81%
74
XLRNAcceleron Pharma Inc.
83,900$3.3B22.55%
75
Menlo Therapeutics Inc.
700,000$3.1B21.33%
76
Harpoon Therapeutics, Inc.
214,285$2.9B19.91%
77
VKTXViking Therapeutics, Inc.
425,000$2.9B19.89%
78
Abeona Therapeutics Inc.
1,288,235$2.9B19.80%
79
GTHXEURG1 Therapeutics, Inc.
127,236$2.9B19.71%
80
Dova Pharmaceuticals, Inc.
102,205$2.9B19.44%
81
Bellicum Pharmaceuticals, Inc.
2,677,818$2.8B19.13%
82
YMABUSDY-mAbs Therapeutics, Inc.
102,800$2.7B18.22%
83
CRNXCrinetics Pharmaceuticals, Inc.
175,000$2.6B17.91%
84
Cyclerion Therapeutics, Inc.
202,581$2.5B16.70%
85
Spring Bank Pharmaceuticals, Inc.
613,144$2.1B14.35%
86
AUTLAutolus Therapeutics plc
156,773$1.9B13.25%
87
IDYAIDEAYA Biosciences, Inc.
200,000$1.8B12.25%
88
NTLAIntellia Therapeutics, Inc.
128,538$1.7B11.67%
89
Molecular Templates, Inc.
254,230$1.7B11.39%
90
Forty Seven, Inc.
250,000$1.6B10.92%
91
Foamix Pharmaceuticals Ltd.
498,189$1.5B10.30%
92
CTMXCytomX Therapeutics, Inc.
194,377$1.4B9.76%
93
CCXIEURChemoCentryx, Inc.
207,029$1.4B9.55%
94
FLGTFulgent Genetics, Inc.
125,000$1.3B8.84%
95
MTNBEURMatinas BioPharma Holdings, Inc.
1,984,965$1.3B8.52%
96
LPTXEURLeap Therapeutics, Inc.
978,454$1.1B7.79%
97
RCUSArcus Biosciences, Inc.
121,534$1.1B7.52%
98
GLMDGalmed Pharmaceuticals Ltd.
215,594$1.0B7.01%
99
Adamas Pharmaceuticals, Inc.
172,630$883.0M6.01%
100
Constellation Pharmaceuticals, Inc.
133,333$861.0M5.86%
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