BAKER BROS. ADVISORS LP Q4 2020 Filing

Filed February 16, 2021

Portfolio Value

$26.5T

Holdings

126

Report Date

Q4 2020

Filing Type

13F-HR

All Holdings (126 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
47,269,424$8.3T31.19%
2
ONCBeiGene, Ltd.
11,668,897$3.0T11.36%
3
INCYIncyte Corporation
31,999,741$2.8T10.49%
4
ACADACADIA Pharmaceuticals Inc.
41,904,586$2.2T8.44%
5
KODKodiak Sciences Inc.
13,879,952$2.0T7.68%
6
ALXNAlexion Pharmaceuticals, Inc.
8,760,794$1.4T5.16%
7
PRLDPrelude Therapeutics Incorporated
10,118,636$724.0B2.73%
8
BMRNBioMarin Pharmaceutical Inc.
7,589,294$665.5B2.51%
9
NVTA1EURInvitae Corporation
15,649,182$654.3B2.46%
10
ASNDAscendis Pharma A/S
3,540,270$590.4B2.22%
11
ABCLAbCellera Biologics Inc.
10,450,180$420.5B1.58%
12
MRTXEURMirati Therapeutics, Inc.
1,409,784$309.6B1.17%
13
ARGXargenx SE
1,019,557$299.8B1.13%
14
1K0IGM Biosciences, Inc.
3,144,892$277.7B1.05%
15
MDGLMadrigal Pharmaceuticals, Inc.
1,499,213$166.7B0.63%
16
AMRNAmarin Corporation plc
27,991,761$136.9B0.52%
17
HRTXHeron Therapeutics, Inc.
5,994,704$126.9B0.48%
18
KYMRKymera Therapeutics, Inc.
1,959,211$121.5B0.46%
19
ALLKGUSDAllakos Inc.
714,250$100.0B0.38%
20
CERSCerus Corporation
13,713,195$94.9B0.36%
21
BCRXBioCryst Pharmaceuticals, Inc.
12,695,818$94.6B0.36%
22
PACBPacific Biosciences of California, Inc.
3,201,972$83.1B0.31%
23
Zymeworks Inc.
1,708,472$80.7B0.30%
24
IM8NInsmed Incorporated
2,156,001$71.8B0.27%
25
Forma Therapeutics Holdings, Inc.
2,024,876$70.7B0.27%
26
RYTMRhythm Pharmaceuticals, Inc.
2,314,873$68.8B0.26%
27
NBIXNeurocrine Biosciences, Inc.
676,975$64.9B0.24%
28
AXSMAxsome Therapeutics, Inc.
778,834$63.5B0.24%
29
RAREUltragenyx Pharmaceutical Inc.
444,444$61.5B0.23%
30
NRIXNurix Therapeutics, Inc.
1,788,921$58.8B0.22%
31
BCELAtreca, Inc.
3,532,760$57.1B0.21%
32
Neoleukin Therapeutics, Inc.
3,821,740$53.9B0.20%
33
ADAPYAdaptimmune Therapeutics plc
9,830,877$53.0B0.20%
34
APLSApellis Pharmaceuticals, Inc.
896,551$51.3B0.19%
35
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$49.5B0.19%
36
ADCTADC Therapeutics SA
1,418,107$45.4B0.17%
37
ALGSAligos Therapeutics, Inc.
1,610,000$44.5B0.17%
38
HZNPHorizon Therapeutics Public Ltd Co
599,110$43.8B0.17%
39
KRYSKrystal Biotech, Inc.
698,874$41.9B0.16%
40
CCXIEURChemoCentryx, Inc.
656,710$40.7B0.15%
41
GBTUSDGlobal Blood Therapeutics, Inc.
920,375$39.9B0.15%
42
DBV Technologies S.A.
14,614,264$38.3B0.14%
43
OPTEYOpthea Limited
3,308,705$37.1B0.14%
44
MRUSMerus N.V.
2,037,469$35.7B0.13%
45
ALKSAlkermes plc
1,535,149$30.6B0.12%
46
Frequency Therapeutics, Inc.
856,507$30.2B0.11%
47
PTGXProtagonist Therapeutics, Inc.
1,436,192$29.0B0.11%
48
BCABBioAtla, Inc.
825,000$28.1B0.11%
49
RETAEURReata Pharmaceuticals, Inc.
223,976$27.7B0.10%
50
Athira Pharma, Inc.
806,367$27.6B0.10%
51
AGLEUSDAeglea BioTherapeutics, Inc.
3,410,106$26.8B0.10%
52
FLGTFulgent Genetics, Inc.
495,573$25.8B0.10%
53
ADPTAdaptive Biotechnologies Corporation
379,682$22.5B0.08%
54
VSTMVerastem, Inc.
10,144,039$21.6B0.08%
55
MREOMereo BioPharma Group plc
6,030,293$21.6B0.08%
56
ALTAltimmune, Inc.
1,884,451$21.3B0.08%
57
AUPHAurinia Pharmaceuticals Inc.
1,410,064$19.5B0.07%
58
IMTXImmatics N.V.
1,805,025$19.5B0.07%
59
NVV1Novavax, Inc.
169,706$18.9B0.07%
60
Idera Pharmaceuticals, Inc.
4,608,786$16.9B0.06%
61
CBAYUSDCymabay Therapeutics, Inc.
2,893,276$16.6B0.06%
62
Invitae Corporation
10,300,000$16.4B0.06%
63
XNCRXencor, Inc.
369,370$16.1B0.06%
64
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$16.0B0.06%
65
BDQMAlbireo Pharma, Inc.
412,466$15.5B0.06%
66
GBYSangamo Therapeutics, Inc.
857,339$13.4B0.05%
67
GW Pharmaceuticals plc
112,897$13.0B0.05%
68
Gamida Cell Ltd.
1,548,314$13.0B0.05%
69
290AChinook Therapeutics, Inc.
748,693$11.9B0.04%
70
Five Prime Therapeutics, Inc.
668,000$11.4B0.04%
71
MIRMMirum Pharmaceuticals, Inc.
647,313$11.3B0.04%
72
SPRYSilverback Therapeutics, Inc.
238,095$11.0B0.04%
73
XENEXenon Pharmaceuticals Inc.
687,386$10.6B0.04%
74
bluebird bio, Inc.
226,988$9.8B0.04%
75
OPHTEURIVERIC bio, Inc.
1,406,037$9.7B0.04%
76
ASMBAssembly Biosciences, Inc.
1,541,418$9.3B0.04%
77
ANABAnaptysBio, Inc.
427,179$9.2B0.03%
78
CRNXCrinetics Pharmaceuticals, Inc.
616,520$8.7B0.03%
79
VXRTVaxart, Inc.
1,398,795$8.0B0.03%
80
CABACabaletta Bio, Inc.
636,363$7.9B0.03%
81
HOOKGBPHOOKIPA Pharma Inc.
700,481$7.8B0.03%
82
Syros Pharmaceuticals, Inc.
690,167$7.5B0.03%
83
DNLIDenali Therapeutics Inc.
88,738$7.4B0.03%
84
KRTXKaruna Therapeutics, Inc.
69,966$7.1B0.03%
85
AUTLAutolus Therapeutics plc
782,183$7.0B0.03%
86
HRMYHarmony Biosciences Holdings, Inc.
180,000$6.5B0.02%
87
Genetron Holdings Limited
455,306$6.4B0.02%
88
NTLAIntellia Therapeutics, Inc.
111,296$6.1B0.02%
89
PASGPassage Bio, Inc.
235,362$6.0B0.02%
90
REPLReplimune Group, Inc.
153,512$5.9B0.02%
91
5E7Iteos Therapeutics, Inc.
150,346$5.1B0.02%
92
TARAProtara Therapeutics, Inc.
199,671$4.8B0.02%
93
BNRBurning Rock Biotech Limited
209,131$4.8B0.02%
94
GOSSGossamer Bio, Inc.
480,729$4.6B0.02%
95
MGNXMacroGenics, Inc.
200,679$4.6B0.02%
96
1T7Tricida, Inc.
629,300$4.4B0.02%
97
IFRXInflarx N.V.
856,228$4.3B0.02%
98
ALECAlector, Inc.
239,228$3.6B0.01%
99
LogicBio Therapeutics, Inc.
451,478$3.4B0.01%
100
TCR2 Therapeutics Inc.
110,888$3.4B0.01%
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