TWO SIGMA INVESTMENTS, LP Q2 2021 Filing

Filed August 16, 2021

Portfolio Value

$44.1M

Holdings

2,682

Report Date

Q2 2021

Filing Type

13F-HR

All Holdings (2,682 positions)

#	Stock	Shares	Value	% Portfolio	Type
2601	SWN1EURSOUTHWESTERN ENERGY CO	18,600	$105K	0.24%	Call
2602	ACBAURORA CANNABIS INC	11,647	$105K	0.24%
2603	CMBTEURONAV NV	10,900	$102K	0.23%	Put
2604	LXULSB INDS INC	16,769	$101K	0.23%
2605	USIOUSIO INC	15,612	$100K	0.23%
2606	—EYEGATE PHARMACEUTICALS INC	27,061	$99K	0.22%
2607	FPAYQFLEXSHOPPER INC	32,345	$96K	0.22%
2608	ZKINZK INTL GROUP CO LTD	22,268	$96K	0.22%
2609	ITIEURITERIS INC NEW	14,266	$95K	0.22%
2610	RXIIEURPHIO PHARMACEUTICALS CORP	41,873	$95K	0.22%
2611	ATOSEURATOSSA THERAPEUTICS INC	15,076	$95K	0.22%
2612	CHTRCHARTER COMMUNICATIONS INC N	130,420	$94K	0.21%	Put
2613	ACICUNITED INS HLDGS CORP	16,566	$94K	0.21%
2614	CASA1EURCASA SYS INC	10,500	$93K	0.21%
2615	—GEMINI THERAPEUTICS INC	14,304	$93K	0.21%
2616	NINEQNINE ENERGY SERVICE INC	31,305	$92K	0.21%
2617	—APPLIED GENETIC TECHNOLOGIES	23,180	$91K	0.21%
2618	DHTDHT HOLDINGS INC	13,900	$90K	0.20%
2619	ARCARC DOCUMENT SOLUTIONS INC	42,061	$90K	0.20%
2620	PSHGPERFORMANCE SHIPPING INC	16,160	$89K	0.20%
2621	LYGLLOYDS BANKING GROUP PLC	34,997	$89K	0.20%
2622	MISTMILESTONE PHARMACEUTICALS IN	16,235	$89K	0.20%
2623	—IMPEL NEUROPHARMA INC	10,043	$89K	0.20%
2624	ALRMALARM COM HLDGS INC	34,760	$88K	0.20%	Put
2625	—PCTEL INC	13,200	$86K	0.20%
2626	—O2MICRO INTERNATIONAL LIMITE	11,944	$86K	0.20%
2627	CIACITIZENS INC	16,091	$85K	0.19%
2628	—AYRO INC	16,900	$82K	0.19%	Put
2629	SLESUPER LEAGUE GAMING INC	15,110	$81K	0.18%
2630	NVDANVIDIA CORPORATION	99,500	$80K	0.18%	Put
2631	—IDEANOMICS INC	27,822	$79K	0.18%
2632	MEIPUSDMEI PHARMA INC	26,955	$77K	0.17%
2633	—HEXO CORP	13,281	$77K	0.17%
2634	—BIOLASE INC	108,877	$76K	0.17%
2635	RIBTEURRICEBRAN TECHNOLOGIES	64,814	$73K	0.17%
2636	—CALYXT INC	18,185	$73K	0.17%
2637	—TREVENA INC	42,912	$73K	0.17%
2638	OPKOPKO HEALTH INC	17,804	$72K	0.16%
2639	DHXDHI GROUP INC	20,924	$71K	0.16%
2640	ONCONCOLYTICS BIOTECH INC	25,200	$70K	0.16%
2641	ATYRATYR PHARMA INC	14,446	$70K	0.16%
2642	ASRVAMERISERV FINL INC	17,170	$67K	0.15%
2643	—ATHERSYS INC NEW	44,700	$64K	0.15%
2644	GPRCHFGREAT PANTHER MNG LTD	100,796	$63K	0.14%
2645	—TD HLDGS INC	59,557	$60K	0.14%
2646	MLB1MERCADOLIBRE INC	38,484	$60K	0.14%	Put
2647	ACIALBERTSONS COS INC	53,400	$59K	0.13%	Put
2648	—EASTSIDE DISTILLING INC	20,041	$57K	0.13%
2649	VYGRVOYAGER THERAPEUTICS INC	13,459	$56K	0.13%
2650	RHRH	76,162	$52K	0.12%	Put
2651	—T2 BIOSYSTEMS INC	41,720	$50K	0.11%
2652	—STRONGBRIDGE BIOPHARMA PLC	16,300	$48K	0.11%
2653	CPSSCONSUMER PORTFOLIO SVCS INC	10,708	$48K	0.11%
2654	—SUMMIT WIRELESS TECH INC	10,497	$42K	0.10%
2655	SOHOSOTHERLY HOTELS INC	13,487	$40K	0.09%
2656	BDQMALBIREO PHARMA INC	54,292	$39K	0.09%
2657	—REWALK ROBOTICS LTD	23,052	$39K	0.09%
2658	—CALITHERA BIOSCIENCES INC	17,700	$37K	0.08%
2659	—WASHINGTON PRIME GROUP NEW	16,990	$37K	0.08%
2660	ALBALBEMARLE CORP	25,300	$35K	0.08%	Put
2661	JOBGEE GROUP INC	58,900	$34K	0.08%
2662	—TRINITY BIOTECH PLC	11,095	$33K	0.07%
2663	ASMLASML HOLDING N V	37,797	$26K	0.06%	Put
2664	AZOAUTOZONE INC	16,837	$25K	0.06%	Put
2665	REGNREGENERON PHARMACEUTICALS	44,600	$25K	0.06%	Put
2666	—BRICKELL BIOTECH INC	23,885	$23K	0.05%
2667	TMOTHERMO FISHER SCIENTIFIC INC	43,245	$22K	0.05%	Put
2668	MTNBEURMATINAS BIOPHARMA HLDGS INC	26,231	$20K	0.05%
2669	—AGILE THERAPEUTICS INC	14,305	$19K	0.04%
2670	SAMBOSTON BEER INC	16,200	$17K	0.04%	Put
2671	TPLTEXAS PACIFIC LAND CORPORATI	10,261	$16K	0.04%
2672	BLKCHFBLACKROCK INC	18,519	$16K	0.04%	Put
2673	—TANTECH HLDGS LTD	12,861	$16K	0.04%
2674	—PALATIN TECHNOLOGIES INC	26,573	$16K	0.04%
2675	ADBEADOBE SYSTEMS INCORPORATED	26,200	$15K	0.03%	Put
2676	TOVXSYNTHETIC BIOLOGICS INC	21,775	$13K	0.03%
2677	ZBRAZEBRA TECHNOLOGIES CORPORATI	23,597	$12K	0.03%	Put
2678	NOWSERVICENOW INC	16,530	$9K	0.02%	Put
2679	CMGCHIPOTLE MEXICAN GRILL INC	5,000	$8K	0.02%	Put
2680	MIGAMICROSTRATEGY INC	6,000	$4K	0.01%	Put
2681	MTDMETTLER TOLEDO INTERNATIONAL	2,504	$3K	0.01%
2682	FCNCAFIRST CTZNS BANCSHARES INC N	3,200	$3K	0.01%

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