| 1 | EcoR1 Capital, LLC | 2,228,000 | $4.3M | 0.20% | Share |
| 2 | Affinity Asset Advisors, LLC | 2,057,200 | $4.0M | 0.23% | Share |
| 3 | Logos Global Management LP | 2,000,000 | $3.9M | 0.23% | Share |
| 4 | Frazier Life Sciences Management, L.P. | 1,953,467 | $3.8M | 0.10% | Share |
| 5 | BALYASNY ASSET MANAGEMENT L.P. | 1,096,179 | $2.0M | 0.00% | Share |
| 6 | Ikarian Capital, LLC | 957,062 | $1.8M | 0.14% | Share |
| 7 | Sio Capital Management, LLC | 740,000 | $1.4M | 0.22% | Share |
| 8 | VANGUARD GROUP INC | 739,830 | $1.4M | 0.00% | Share |
| 9 | AMERIPRISE FINANCIAL INC | 584,368 | $1.0M | 0.00% | Share |
| 10 | ADAR1 Capital Management, LLC | 405,531 | $782K | 0.06% | Share |
| 11 | Monashee Investment Management LLC | 274,862 | $530K | 0.30% | Share |
| 12 | NOESIS CAPITAL MANGEMENT CORP | 224,200 | $432K | 0.06% | Share |
| 13 | VANGUARD GROUP INC | 137,859 | $266K | 0.00% | Share |
| 14 | SILVERARC CAPITAL MANAGEMENT, LLC | 106,000 | $204K | 0.03% | Share |
| 15 | UBS Group AG | 82,165 | $158K | 0.00% | Share |
| 16 | Mountain Capital Investment Advisors Inc. | 63,000 | $141K | 0.02% | Share |
| 17 | UBS Group AG | 44,390 | $85K | 0.00% | Share |
| 18 | Persistent Asset Partners Ltd | 39,585 | $76K | 0.03% | Share |
| 19 | PFG Investments, LLC | 21,500 | $41K | 0.00% | Share |
| 20 | VANGUARD GROUP INC | 5,460 | $10K | 0.00% | Share |
| 21 | XTX Topco Ltd | 37,014 | $0 | 0.00% | Share |
| 22 | BARCLAYS PLC | 2 | $0 | 0.00% | Share |
| 23 | CITIGROUP INC | 5,046 | $0 | 0.00% | Share |
| 24 | STATE STREET CORP | 72,899 | $0 | 0.00% | Share |
| 25 | RENAISSANCE TECHNOLOGIES LLC | 353,339 | $0 | 0.00% | Share |
| 26 | Jefferies Financial Group Inc. | 160,000 | $0 | 0.00% | Share |
| 27 | JANE STREET GROUP, LLC | 52,989 | $0 | 0.00% | Share |
| 28 | JANE STREET GROUP, LLC | 52,711 | $0 | 0.00% | Share |
| 29 | Steward Partners Investment Advisory, LLC | 1 | $0 | 0.00% | Share |
| 30 | MARSHALL WACE, LLP | 121,286 | $0 | 0.00% | Share |
| 31 | Activest Wealth Management | 4 | $0 | 0.00% | Share |
| 32 | SBI Securities Co., Ltd. | 22 | $0 | 0.00% | Share |
| 33 | UBS Group AG | 1 | $0 | 0.00% | Share |
| 34 | SOA Wealth Advisors, LLC. | 13 | $0 | 0.00% | Share |
| 35 | Fortitude Family Office, LLC | 431 | $0 | 0.00% | Share |
| 36 | WELLS FARGO & COMPANY/MN | 1 | $0 | 0.00% | Share |
| 37 | OSAIC HOLDINGS, INC. | 304 | $0 | 0.00% | Share |
| 38 | OSAIC HOLDINGS, INC. | 80 | $0 | 0.00% | Share |
| 39 | BANK OF AMERICA CORP /DE/ | 1,213 | $0 | 0.00% | Share |
| 40 | Hudson Bay Capital Management LP | 242,076 | $0 | 0.00% | Share |
| 41 | Arax Advisory Partners | 91 | $0 | 0.00% | Share |
| 42 | Walleye Capital LLC | 198,375 | $0 | 0.00% | Share |
| 43 | Vanguard Personalized Indexing Management, LLC | 12,491 | $0 | 0.00% | Share |
| 44 | BNP PARIBAS FINANCIAL MARKETS | 5 | $0 | 0.00% | Share |
| 45 | MORGAN STANLEY | 27,587 | $0 | 0.00% | Share |
| 46 | MORGAN STANLEY | 1 | $0 | 0.00% | Share |
| 47 | MORGAN STANLEY | 7 | $0 | 0.00% | Share |
| 48 | BlackRock, Inc. | 42,727 | $0 | 0.00% | Share |
| 49 | JPMORGAN CHASE & CO | 2 | $0 | 0.00% | Share |
| 50 | BANK OF AMERICA CORP /DE/ | 2 | $0 | 0.00% | Share |