Who Owns Mineralys Therapeutics, Inc. (MLYS)?Hedge Fund & Institutional Holders

$26.52-0.47 (-1.74%)HealthcareNASDAQ

Institutional Holders

50

as of Q4 2025

Total Institutional Value

$InfinityT

% of Float Held

Infinity%

QoQ Change in Holders

+8 / -2

Price History

$8.76$18.40$28.05$37.69$47.33Sep 24Jun 25Mar 26

MLYS — Biggest New Institutional Buyers This Quarter

FundActionShares AddedValue Added
FMR LLCIncreased+3.0M+$181.9B
SAMLYN CAPITAL, LLCNew Position+1.3M+$47.4B
JENNISON ASSOCIATES LLCNew Position+1.3M+$45.7B
JANUS HENDERSON GROUP PLCIncreased+1.2M+$42.2B
BANK OF AMERICA CORP /DE/Increased+219K+$34.0B
Siren, L.L.C.New Position+700K+$25.4B
GOLDMAN SACHS GROUP INCIncreased+739K+$24.0B
Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.New Position+659K+$23.9B
TWO SIGMA INVESTMENTS, LPNew Position+610K+$22.0B
D. E. Shaw & Co., Inc.Increased+540K+$17.8B
TimesSquare Capital Management, LLCNew Position+380K+$13.8B
Holocene Advisors, LPIncreased+397K+$12.3B
Catalio Capital Management, LPNew Position+332K+$12.0B
TWO SIGMA ADVISERS, LPNew Position+354K+$12.0B
Polar Capital Holdings PlcIncreased+342K+$9.9B

MLYS — Institutions Reducing or Closing Positions

FundActionShares SoldValue Sold
Capital International InvestorsDecreased-1.2M-$90.7B
CITADEL ADVISORS LLCDecreased-1.7M-$65.4B
Catalys Pacific, LLCDecreased-1.0M-$50.8B
FARALLON CAPITAL MANAGEMENT LLCDecreased-850K-$33.6B
Integral Health Asset Management, LLCDecreased-750K-$29.7B
Point72 Asset Management, L.P.Decreased-592K-$25.2B
SUVRETTA CAPITAL MANAGEMENT, LLCDecreased-593K-$25.0B
SR ONE CAPITAL MANAGEMENT, LPDecreased-550K-$23.4B
ORBIMED ADVISORS LLCDecreased-489K-$20.1B
Pale Fire Capital SEDecreased-522K-$19.8B
BARCLAYS PLCDecreased-431K-$17.8B
Nearwater Capital Markets, LtdClosed Position-450K-$17.1B
MILLENNIUM MANAGEMENT LLCDecreased-326K-$13.3B
FINDELL CAPITAL MANAGEMENT LLCDecreased-200K-$7.7B
TANG CAPITAL MANAGEMENT LLCClosed Position-200K-$7.6B

Top Institutional Holders(Q4 2025)

#FundSharesValue% of PortfolioType
1Catalys Pacific, LLC7,903,838$286.8B92.37%Share
2FMR LLC4,210,069$152.0B0.01%Share
3Caligan Partners LP2,772,654$100.6B8.28%Share
4Caligan Partners LP2,298,400$83.4B6.87%Put
5FRANKLIN RESOURCES INC1,785,136$64.0B0.02%Share
6Laurion Capital Management LP1,713,485$62.2B1.90%Share
7Holocene Advisors, LP1,602,035$58.0B0.12%Share
8SR ONE CAPITAL MANAGEMENT, LP1,563,966$56.8B8.03%Share
9SUVRETTA CAPITAL MANAGEMENT, LLC1,538,662$55.8B1.14%Share
10Polar Capital Holdings Plc1,401,141$50.0B0.19%Share
11JENNISON ASSOCIATES LLC1,258,653$45.7B0.03%Share
12Caption Management, LLC1,227,400$44.5B0.31%Call
13Caption Management, LLC1,221,800$44.3B0.30%Put
14Point72 Asset Management, L.P.1,207,220$43.0B0.05%Share
15JANUS HENDERSON GROUP PLC1,193,417$43.0B0.02%Share
16D. E. Shaw & Co., Inc.1,150,670$41.0B0.02%Share
17ORBIMED ADVISORS LLC980,400$35.6B0.73%Share
18ALLIANCEBERNSTEIN L.P.922,516$33.0B0.01%Share
19AMERICAN CENTURY COMPANIES INC908,093$32.0B0.02%Share
20BANK OF AMERICA CORP /DE/846,624$30.0B0.00%Share
21GOLDMAN SACHS GROUP INC852,683$30.0B0.00%Share
22FARALLON CAPITAL MANAGEMENT LLC823,296$29.9B0.14%Share
23FMR LLC782,068$28.0B0.00%Share
24Integral Health Asset Management, LLC750,000$27.2B1.35%Share
25Affinity Asset Advisors, LLC730,000$26.5B1.51%Share
26Siren, L.L.C.699,999$25.4B0.76%Share
27Candriam S.C.A.678,387$24.0B0.12%Share
28Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A.659,076$23.9B2.12%Share
29TWO SIGMA INVESTMENTS, LP610,403$22.0B0.03%Share
30GOLDMAN SACHS GROUP INC598,250$21.0B0.00%Share
31SUSQUEHANNA INTERNATIONAL GROUP, LLP570,800$20.0B0.00%Put
32SAMLYN CAPITAL, LLC527,281$19.1B0.30%Share
33SUSQUEHANNA INTERNATIONAL GROUP, LLP483,700$17.0B0.00%Call
34WELLINGTON MANAGEMENT GROUP LLP475,432$17.0B0.00%Share
35SAMLYN CAPITAL, LLC455,643$16.5B0.26%Share
36CHARLES SCHWAB INVESTMENT MANAGEMENT INC461,300$16.0B0.00%Share
37Rock Springs Capital Management LP427,596$15.5B0.80%Share
38TimesSquare Capital Management, LLC380,100$13.8B0.21%Share
3922NW, LP358,325$13.0B5.49%Share
40Catalio Capital Management, LP331,849$12.0B2.13%Share
41TWO SIGMA ADVISERS, LP353,700$12.0B0.02%Share
42CITADEL ADVISORS LLC351,737$12.0B0.00%Share
43RENAISSANCE TECHNOLOGIES LLC322,100$11.0B0.02%Share
44STEMPOINT CAPITAL LP290,049$10.5B1.80%Share
45Integral Health Asset Management, LLC250,000$9.1B0.45%Call
46NORTHERN TRUST CORP265,301$9.0B0.00%Share
47SAMLYN CAPITAL, LLC235,789$8.6B0.14%Share
48MILLENNIUM MANAGEMENT LLC225,000$8.0B0.00%Call
49WELLINGTON MANAGEMENT GROUP LLP222,422$8.0B0.00%Share
50UBS Group AG193,733$7.0B0.00%Share

MLYS Institutional Ownership History

QuarterHoldersTotal ValueChange
Q4 2025222$1.8T+56
Q3 2025166$2.1T+24
Q2 2025142$450.8B-10
Q1 2025152$786.0B+43
Q4 2024109$427.7B+15
Q3 202494$9.1T+10
Q2 202484$7.3T+3
Q1 202481$16.6T—

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As of Q4 2025, 50 institutional investors hold MLYS (Mineralys Therapeutics, Inc.). The largest holder is Catalys Pacific, LLC with $286.8B in shares. This quarter, 8 institutions opened new positions and 2 closed their positions.

Frequently Asked Questions

How many hedge funds own MLYS?

As of Q4 2025, 50 institutional investors report holding MLYS (Mineralys Therapeutics, Inc.) in their 13F filings.

Who is the largest institutional holder of MLYS?

The largest institutional holder of MLYS is Catalys Pacific, LLC with $286.8B in shares.

Is institutional ownership of MLYS increasing or decreasing?

This quarter, 8 institutions opened new positions in MLYS and 2 closed their positions.