| 1 | ABG Innovation Capital Partners III GP Ltd | 26,666 | $64.5M | 100.00% | Share |
| 2 | QVT Financial LP | 4,615,709 | $10.6M | 0.91% | Share |
| 3 | ORBIMED ADVISORS LLC | 4,166,000 | $10.1M | 0.21% | Share |
| 4 | SUVRETTA CAPITAL MANAGEMENT, LLC | 3,700,000 | $9.0M | 0.18% | Share |
| 5 | ACUTA CAPITAL PARTNERS, LLC | 3,410,402 | $8.3M | 5.60% | Share |
| 6 | Avoro Capital Advisors LLC | 2,849,402 | $6.9M | 0.07% | Share |
| 7 | KVP Capital Advisors, LP | 2,165,997 | $5.2M | 5.07% | Share |
| 8 | Siren, L.L.C. | 2,082,000 | $5.0M | 0.15% | Share |
| 9 | Yu Fan | 2,070,000 | $5.0M | 5.43% | Share |
| 10 | STEMPOINT CAPITAL LP | 1,458,807 | $3.5M | 0.61% | Share |
| 11 | VANGUARD GROUP INC | 1,355,113 | $3.3M | 0.00% | Share |
| 12 | ACORN CAPITAL ADVISORS, LLC | 1,139,363 | $2.8M | 0.93% | Share |
| 13 | Ally Bridge Group (NY) LLC | 817,939 | $2.0M | 2.06% | Share |
| 14 | RENAISSANCE TECHNOLOGIES LLC | 440,722 | $1.0M | 0.00% | Share |
| 15 | Eversept Partners, LP | 260,259 | $629K | 0.03% | Share |
| 16 | VANGUARD GROUP INC | 214,827 | $519K | 0.00% | Share |
| 17 | ADAR1 Capital Management, LLC | 77,593 | $187K | 0.01% | Share |
| 18 | UBS Group AG | 22,436 | $54K | 0.00% | Share |
| 19 | VANGUARD GROUP INC | 20,177 | $48K | 0.00% | Share |
| 20 | UBS Group AG | 7,408 | $17K | 0.00% | Share |
| 21 | US BANCORP \DE\ | 3,333 | $8K | 0.00% | Share |
| 22 | BARTLETT & CO. WEALTH MANAGEMENT LLC | 1,333 | $3K | 0.00% | Share |
| 23 | Torren Management, LLC | 1,254 | $3K | 0.00% | Share |
| 24 | GROUP ONE TRADING LLC | 1,500 | $3K | 0.00% | Call |
| 25 | BNP PARIBAS FINANCIAL MARKETS | 160 | $0 | 0.00% | Share |
| 26 | Russell Investments Group, Ltd. | 386 | $0 | 0.00% | Share |
| 27 | MORGAN STANLEY | 1,799 | $0 | 0.00% | Share |
| 28 | JPMORGAN CHASE & CO | 121 | $0 | 0.00% | Share |
| 29 | GROUP ONE TRADING LLC | 100 | $0 | 0.00% | Share |
| 30 | Quadrature Capital Ltd | 11,447 | $0 | 0.00% | Share |
| 31 | SBI Securities Co., Ltd. | 19 | $0 | 0.00% | Share |
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 363,673 | $0 | 0.00% | Share |
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 61,767 | $0 | 0.00% | Share |
| 34 | MARSHALL WACE, LLP | 16,714 | $0 | 0.00% | Share |
| 35 | MARSHALL WACE, LLP | 51,245 | $0 | 0.00% | Share |
| 36 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 215,284 | $0 | 0.00% | Share |
| 37 | PRELUDE CAPITAL MANAGEMENT, LLC | 18,796 | $0 | 0.00% | Share |
| 38 | CITADEL ADVISORS LLC | 69,590 | $0 | 0.00% | Share |
| 39 | CITADEL ADVISORS LLC | 29,360 | $0 | 0.00% | Share |
| 40 | CWM, LLC | 25 | $0 | 0.00% | Share |
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 110,083 | $0 | 0.00% | Share |
| 42 | TWO SIGMA ADVISERS, LP | 42,400 | $0 | 0.00% | Share |
| 43 | NORTHERN TRUST CORP | 28,157 | $0 | 0.00% | Share |
| 44 | NORTHERN TRUST CORP | 75,295 | $0 | 0.00% | Share |
| 45 | JANE STREET GROUP, LLC | 1,968 | $0 | 0.00% | Share |
| 46 | DIMENSIONAL FUND ADVISORS LP | 23,692 | $0 | 0.00% | Share |
| 47 | DIMENSIONAL FUND ADVISORS LP | 4,949 | $0 | 0.00% | Share |
| 48 | TWO SIGMA INVESTMENTS, LP | 309,865 | $0 | 0.00% | Share |
| 49 | BANK OF AMERICA CORP /DE/ | 411 | $0 | 0.00% | Share |
| 50 | Parallel Advisors, LLC | 8 | $0 | 0.00% | Share |