5AM Venture Management, LLC

CIK: 0001799883SEC EDGAR →

Portfolio Value

$318.1M

Holdings

21

As of

Q4 2025

New Positions

1

Closed Positions

4

Top 10 Holdings

RankStockSharesValue% of Portfolio
1

ENTRADA THERAPEUTICS INC

4,056,379$41.7M
13.11%
2

CAMP4 THERAPEUTICS CORP

5,869,091$36.0M
11.31%
3

TYRA BIOSCIENCES INC

1,029,298$27.1M
8.51%
4

VIRIDIAN THERAPEUTICS INC

736,595$22.9M
7.21%
5

PHARVARIS N V

797,600$22.1M
6.96%
6

ERASCA INC

5,405,404$20.1M
6.32%
7

EYEPOINT INC

1,050,000$19.2M
6.03%
8

MAPLIGHT THERAPEUTICS INC

950,011$16.7M
5.25%
9

CENTESSA PHARMACEUTICALS PLC

580,945$14.5M
4.57%
10

CELLDEX THERAPEUTICS INC NEW

497,270$13.5M
4.25%

Quarterly Changes

Top Buys

MPLTNEW
$16.7M
TYRA↑ Increased
$13.9M
SRZN↑ Increased
$4.8M
TECX↑ Increased
$4.6M
ZNTL↑ Increased
$4.6M

Top Sells

TRDA↓ Decreased
$17.0M
DNTHCLOSED
$14.4M
PRAXCLOSED
$9.0M
ALECCLOSED
$2.9M
AVU0CLOSED
$2.5M

New Positions (1)

$16.7M · 950K shares

Closed Positions (5)

$14.4M · 365K shares
$9.0M · 170K shares
$2.9M · 996K shares
$2.5M · 542K shares
$405K · 52K shares

Sector Breakdown

Sector# HoldingsValue%
Healthcare20$304.6M95.8%
Unknown1$13.5M4.2%