BAKER BROS. ADVISORS LP Q1 2022 Filing

Filed May 16, 2022

Portfolio Value

$17.4T

Holdings

118

Report Date

Q1 2022

Filing Type

13F-HR

All Holdings (118 positions)

#StockSharesValue% PortfolioType
1
SGENUSDSeagen Inc.
46,912,266$6.8T38.83%
2
INCYIncyte Corporation
36,153,684$2.9T16.50%
3
ONCBeiGene, Ltd.
11,668,897$2.2T12.65%
4
ACADACADIA Pharmaceuticals Inc.
41,910,704$1.0T5.83%
5
BMRNBioMarin Pharmaceutical Inc.
7,620,494$587.5B3.38%
6
ASNDAscendis Pharma A/S
4,541,604$533.0B3.06%
7
ARGXargenx SE
1,119,557$353.0B2.03%
8
BCRXBioCryst Pharmaceuticals, Inc.
12,710,818$206.7B1.19%
9
MDGLMadrigal Pharmaceuticals, Inc.
1,499,213$147.1B0.85%
10
KODKodiak Sciences Inc.
15,931,045$123.0B0.71%
11
MRTXEURMirati Therapeutics, Inc.
1,409,784$115.9B0.67%
12
GBTUSDGlobal Blood Therapeutics, Inc.
3,314,765$114.8B0.66%
13
ABCLAbCellera Biologics Inc.
10,450,180$101.9B0.59%
14
KYMRKymera Therapeutics, Inc.
2,384,742$100.9B0.58%
15
HZNPHorizon Therapeutics Public Ltd Co
898,842$94.6B0.54%
16
TVTXTravere Therapeutics, Inc.
3,300,009$85.0B0.49%
17
1K0IGM Biosciences, Inc.
3,156,102$84.4B0.48%
18
NVTA1EURInvitae Corporation
9,873,488$78.7B0.45%
19
IMCRImmunocore Holdings plc
2,520,730$75.4B0.43%
20
CERSCerus Corporation
13,713,195$75.3B0.43%
21
LEGNLegend Biotech Corporation
2,008,999$73.0B0.42%
22
PRLDPrelude Therapeutics Inc.
10,123,824$69.9B0.40%
23
AMRNAmarin Corporation plc
21,169,805$69.6B0.40%
24
NBIXNeurocrine Biosciences, Inc.
676,975$63.5B0.36%
25
MRUSMerus N.V.
2,037,469$53.9B0.31%
26
KRYSKrystal Biotech, Inc.
807,735$53.7B0.31%
27
IM8NInsmed Incorporated
2,156,001$50.7B0.29%
28
PACBPacific Biosciences of California, Inc.
5,444,963$49.5B0.28%
29
RYTMRhythm Pharmaceuticals, Inc.
4,125,062$47.5B0.27%
30
HRTXHeron Therapeutics, Inc.
8,131,678$46.5B0.27%
31
TRDAEntrada Therapeutics, Inc.
4,704,419$44.2B0.25%
32
TILInstil Bio, Inc.
3,893,700$41.9B0.24%
33
ALKSAlkermes plc
1,500,000$39.5B0.23%
34
INSM 0.75 06/01/28Insmed Incorporated
40,000,000$38.6B0.22%
35
SRPT 1.5 11/15/24Sarepta Therapeutics, Inc.
29,174,000$38.4B0.22%
36
290AChinook Therapeutics, Inc.
2,334,102$38.2B0.22%
37
VSTMVerastem, Inc.
26,988,898$38.1B0.22%
38
AVTEAerovate Therapeutics, Inc.
2,070,010$37.9B0.22%
39
IMTXImmatics N.V.
4,423,731$35.3B0.20%
40
TSVT*2seventy bio, Inc.
2,062,744$35.2B0.20%
41
NRIXNurix Therapeutics, Inc.
2,454,082$34.4B0.20%
42
VERVVerve Therapeutics, Inc.
1,416,530$32.3B0.19%
43
RAREUltragenyx Pharmaceutical Inc.
444,444$32.3B0.19%
44
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$27.8B0.16%
45
REPLReplimune Group, Inc.
1,611,703$27.4B0.16%
46
AXSMAxsome Therapeutics, Inc.
610,970$25.3B0.15%
47
DBV Technologies S.A.
14,614,264$23.2B0.13%
48
DSGNDesign Therapeutics, Inc.
1,436,636$23.2B0.13%
49
CCXIEURChemoCentryx, Inc.
916,862$23.0B0.13%
50
XENEXenon Pharmaceuticals Inc.
751,639$23.0B0.13%
51
Affimed N.V.
5,153,169$22.5B0.13%
52
ADAPYAdaptimmune Therapeutics plc
9,830,877$20.3B0.12%
53
Forma Therapeutics Holdings, Inc.
2,024,876$18.8B0.11%
54
OTICEUROtonomy, Inc.
7,844,692$18.8B0.11%
55
OPTEYOpthea Limited
2,696,191$18.5B0.11%
56
CRNXCrinetics Pharmaceuticals, Inc.
827,480$18.2B0.10%
57
1T7Tricida, Inc.
1,731,714$14.2B0.08%
58
RLMDRelmada Therapeutics, Inc.
495,113$13.4B0.08%
59
FLGTFulgent Genetics, Inc.
201,444$12.6B0.07%
60
bluebird bio, Inc.
2,499,715$12.1B0.07%
61
DICE Therapeutics, Inc.
588,235$11.3B0.06%
62
BCELAtreca, Inc.
3,532,760$11.2B0.06%
63
Zymeworks Inc.
1,708,472$11.2B0.06%
64
Athira Pharma, Inc.
806,367$10.9B0.06%
65
Talis Biomedical Corporation
7,624,835$10.8B0.06%
66
ANABAnaptysBio, Inc.
427,179$10.6B0.06%
67
CNTACentessa Pharmaceuticals plc
1,127,273$10.1B0.06%
68
SRPTSarepta Therapeutics, Inc.
123,456$9.6B0.06%
69
KRTXKaruna Therapeutics, Inc.
69,966$8.9B0.05%
70
Invitae Corporation
10,300,000$8.4B0.05%
71
AGLEUSDAeglea BioTherapeutics, Inc.
3,410,106$7.8B0.05%
72
VERAVera Therapeutics, Inc.
333,333$7.8B0.04%
73
698Achilles Therapeutics plc
2,591,366$7.6B0.04%
74
SRZNSurrozen, Inc.
2,500,000$7.5B0.04%
75
RETAEURReata Pharmaceuticals, Inc.
223,976$7.3B0.04%
76
Neoleukin Therapeutics, Inc.
3,821,740$7.2B0.04%
77
FGENEURFibroGen, Inc.
581,750$7.0B0.04%
78
BMEABiomea Fusion, Inc.
1,551,445$6.9B0.04%
79
CBAYUSDCymaBay Therapeutics, Inc.
2,170,464$6.8B0.04%
80
ALTAltimmune, Inc.
1,072,038$6.5B0.04%
81
HRMYHarmony Biosciences Holdings, Inc.
123,600$6.0B0.03%
82
TNGXTango Therapeutics, Inc.
750,000$5.7B0.03%
83
RVMDRevolution Medicines, Inc.
222,222$5.7B0.03%
84
HOOKGBPHOOKIPA Pharma Inc.
2,400,481$5.5B0.03%
85
EWTXEdgewise Therapeutics, Inc.
500,000$4.8B0.03%
86
5E7Iteos Therapeutics, Inc.
150,346$4.8B0.03%
87
ALGSAligos Therapeutics, Inc.
2,076,400$4.5B0.03%
88
NGMUSDNGM Biopharmaceuticals, Inc.
291,801$4.5B0.03%
89
KURAKura Oncology, Inc.
274,458$4.4B0.03%
90
BCABBioAtla, Inc.
825,000$4.1B0.02%
91
ALLKGUSDAllakos Inc.
703,050$4.0B0.02%
92
TCRXTScan Therapeutics, Inc.
1,425,000$4.0B0.02%
93
MGNXMacroGenics, Inc.
442,579$3.9B0.02%
94
NVV1Novavax, Inc.
48,168$3.5B0.02%
95
ALECAlector, Inc.
239,228$3.4B0.02%
96
ATYRaTyr Pharma, Inc.
625,000$3.3B0.02%
97
CYTCyteir Therapeutics, Inc.
812,640$3.1B0.02%
98
DNLIDenali Therapeutics Inc.
88,738$2.9B0.02%
99
KZRKezar Life Sciences, Inc.
139,676$2.3B0.01%
100
TCR2 Therapeutics Inc.
753,064$2.1B0.01%
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