BAKER BROS. ADVISORS LP Q2 2020 Filing

Filed August 14, 2020

Portfolio Value

$22.7B

Holdings

114

Report Date

Q2 2020

Filing Type

13F-HR

All Holdings (114 positions)

#StockSharesValue% PortfolioType
1
SGENEURSeattle Genetics, Inc.
47,269,424$8.0T35428.63%
2
INCYIncyte Corporation
31,999,081$3.3T14674.89%
3
ONCBeiGene, Ltd.
11,777,285$2.2T9787.13%
4
ACADACADIA Pharmaceuticals Inc.
41,904,586$2.0T8959.09%
5
ALXNAlexion Pharmaceuticals, Inc.
8,760,794$983.3B4337.31%
6
BMRNBioMarin Pharmaceutical Inc.
7,589,294$936.1B4128.91%
7
KODKodiak Sciences Inc.
11,574,538$626.4B2763.06%
8
ASNDAscendis Pharma A/S
3,390,270$501.4B2211.73%
9
NVTA1EURInvitae Corporation
11,850,962$359.0B1583.37%
10
MyoKardia, Inc.
3,164,234$305.7B1348.54%
11
AMRNAmarin Corporation plc
34,496,685$238.7B1052.96%
12
ARGXargenx SE
1,019,557$229.6B1012.90%
13
1K0IGM Biosciences, Inc.
3,144,223$229.5B1012.43%
14
MDGLMadrigal Pharmaceuticals, Inc.
1,499,212$169.8B748.91%
15
MRTXEURMirati Therapeutics, Inc.
1,409,784$161.0B709.96%
16
EXASExact Sciences Corporation
1,846,139$160.5B707.97%
17
NBIXNeurocrine Biosciences, Inc.
906,986$110.7B488.08%
18
Principia Biopharma Inc.
1,580,873$94.5B416.92%
19
Forma Therapeutics Holdings, Inc.
2,000,000$93.0B410.13%
20
CERSCerus Corporation
13,713,195$90.5B399.22%
21
HRTXHeron Therapeutics, Inc.
6,018,104$88.5B390.48%
22
IM8NInsmed Incorporated
3,025,384$83.3B367.51%
23
AXSMAxsome Therapeutics, Inc.
1,009,757$83.1B366.47%
24
ADCTADC Therapeutics SA
1,687,500$79.0B348.43%
25
BCELAtreca, Inc.
3,532,760$75.2B331.60%
26
KNSAKiniksa Pharmaceuticals, Ltd.
2,799,577$71.3B314.64%
27
ADAPYAdaptimmune Therapeutics plc
6,675,181$66.8B294.73%
28
BCRXBioCryst Pharmaceuticals, Inc.
13,766,405$65.6B289.34%
29
DBV Technologies S.A.
14,614,264$64.2B282.99%
30
Zymeworks Inc.
1,708,472$61.6B271.82%
31
RYTMRhythm Pharmaceuticals, Inc.
2,700,055$60.2B265.59%
32
Neoleukin Therapeutics, Inc.
3,397,740$56.4B248.78%
33
CCXIEURChemoCentryx, Inc.
945,221$54.4B239.90%
34
ALLKGUSDAllakos Inc.
735,469$52.9B233.12%
35
NBIX 2.25 05/15/24Neurocrine Biosciences, Inc.
30,770,000$51.1B225.59%
36
AGLEUSDAeglea BioTherapeutics, Inc.
4,379,592$40.5B178.69%
37
ASMBAssembly Biosciences, Inc.
1,541,618$36.0B158.58%
38
KRYSKrystal Biotech, Inc.
817,631$33.9B149.38%
39
PTGXProtagonist Therapeutics, Inc.
1,911,446$33.8B148.90%
40
MRUSMerus N.V.
2,037,469$32.8B144.60%
41
APLSApellis Pharmaceuticals, Inc.
896,551$29.3B129.16%
42
AUPHAurinia Pharmaceuticals Inc.
1,701,929$27.7B121.99%
43
ALKSAlkermes plc
1,244,744$24.2B106.54%
44
GW Pharmaceuticals plc
185,045$22.7B100.17%
45
ALTAltimmune, Inc.
2,107,600$22.6B99.56%
46
ADPTAdaptive Biotechnologies Corporation
463,539$22.4B98.92%
47
Frequency Therapeutics, Inc.
945,719$22.0B96.99%
48
1T7Tricida, Inc.
787,582$21.6B95.47%
49
NVV1Novavax, Inc.
241,376$20.1B88.74%
50
BMRN 0.599 08/01/24BioMarin Pharmaceutical Inc.
15,000,000$18.3B80.90%
51
bluebird bio, Inc.
265,000$16.2B71.35%
52
VXRTVaxart, Inc.
1,639,121$14.5B63.98%
53
XNCRXencor, Inc.
428,120$13.9B61.17%
54
Immunomedics, Inc.
330,000$11.7B51.59%
55
ANABAnaptysBio, Inc.
513,677$11.5B50.62%
56
MIRMMirum Pharmaceuticals, Inc.
583,333$11.4B50.07%
57
Aimmune Therapeutics, Inc.
673,908$11.3B49.67%
58
HZNPHorizon Therapeutics Public Ltd Co
200,000$11.1B49.03%
59
QUREuniQure N.V.
230,883$10.4B45.89%
60
XENEXenon Pharmaceuticals Inc.
799,102$10.0B44.20%
61
Urovant Sciences Ltd.
1,000,000$9.8B43.40%
62
BDQMAlbireo Pharma, Inc.
369,047$9.8B43.12%
63
KRTXKaruna Therapeutics, Inc.
81,976$9.1B40.30%
64
FLGTFulgent Genetics, Inc.
569,444$9.1B40.19%
65
GBYSangamo Therapeutics, Inc.
999,823$9.0B39.51%
66
RETAEURReata Pharmaceuticals, Inc.
55,983$8.7B38.53%
67
OPHTEURIVERIC bio, Inc.
1,635,501$8.3B36.79%
68
Idera Pharmaceuticals, Inc.
4,608,786$8.3B36.39%
69
HOOKGBPHOOKIPA Pharma Inc.
700,481$8.1B35.90%
70
AUTLAutolus Therapeutics plc
485,624$7.8B34.34%
71
PASGPassage Bio, Inc.
275,000$7.5B33.15%
72
Syros Pharmaceuticals, Inc.
690,167$7.4B32.45%
73
CABACabaletta Bio, Inc.
636,363$7.1B31.27%
74
ALECAlector, Inc.
280,000$6.8B30.18%
75
BNRBurning Rock Biotech Limited
250,000$6.8B29.79%
76
TARAProtara Therapeutics, Inc.
199,671$5.9B25.82%
77
LEGNLegend Biotech Corporation
135,000$5.7B25.35%
78
CRNXCrinetics Pharmaceuticals, Inc.
317,857$5.6B24.56%
79
CBAYUSDCymaBay Therapeutics, Inc.
1,522,792$5.3B23.44%
80
Chiasma, Inc.
946,701$5.1B22.46%
81
IFRXInflarx N.V.
1,058,555$4.9B21.43%
82
Abeona Therapeutics Inc.
1,590,686$4.6B20.45%
83
Evofem Biosciences, Inc.
1,425,000$4.0B17.79%
84
Constellation Pharmaceuticals, Inc.
133,333$4.0B17.67%
85
OVIDOvid Therapeutics Inc.
458,253$3.4B14.90%
86
KZRKezar Life Sciences, Inc.
600,000$3.1B13.71%
87
VKTXViking Therapeutics, Inc.
425,000$3.1B13.52%
88
Gamida Cell Ltd.
666,666$3.0B13.44%
89
Dicerna Pharmaceuticals, Inc.
119,335$3.0B13.37%
90
RCUSArcus Biosciences, Inc.
121,534$3.0B13.26%
91
GBTUSDGlobal Blood Therapeutics, Inc.
47,000$3.0B13.09%
92
VSAREURAravive, Inc.
244,055$2.8B12.53%
93
NTLAIntellia Therapeutics, Inc.
128,538$2.7B11.92%
94
GLPGGalapagos NV
13,072$2.6B11.38%
95
XLRNAcceleron Pharma Inc.
27,000$2.6B11.34%
96
DNLIDenali Therapeutics Inc.
104,900$2.5B11.19%
97
NGMUSDNGM Biopharmaceuticals, Inc.
124,400$2.5B10.83%
98
ORTXUSDOrchard Therapeutics plc
405,702$2.4B10.74%
99
APLTApplied Therapeutics, Inc.
65,934$2.4B10.52%
100
ARYA Sciences Acquisition Corp.
150,000$2.4B10.41%
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